Results 31 to 40 of about 195,760 (256)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigation of Mechano-Electrochemical Effects on Hydrogen Distribution at Corrosion Defects

Hydrogen
This study employed tensile test, hydrogen permeation measurements, and potentiodynamic polarization testing to investigate the mechanical properties, hydrogen diffusion coefficients, and electrochemical behavior of X80 steel. A multifield coupled finite
Zhixiang Dai, Jiamin Tang, Sijia Zheng, Feng Wang, Qin Bie, Pengcheng Kang, Xinyi Wang, Shiwen Guo, Lin Chen   +8 more
doaj   +1 more source

Impact of yttrium hydride formation on multi-isotopic hydrogen retention by a getter trap for the DONES lithium loop

Nuclear Fusion, 2023
Compliance with imposed hydrogen concentration limits in the lithium loop of the DEMO-Oriented Neutron Source (DONES) requires the installation of an yttrium-based hydrogen trap.
S.J. Hendricks, J. Molla, F.R. Urgorri, E. Carella   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical Analysis of the Hydrogen Dispersion Behavior in Different Directions in a Naturally Ventilated Space

Applied Sciences, 2021
Studies on hydrogen leakage have mainly focused on the influences of location and geometrical configuration on the distribution of the hydrogen in various spaces.
Xiaolu Zhang, Qiubo Wang, Xulei Hou, Yuejuan Li, Yang Miao, Kun Li, Li Zhang   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Study on Diffusion of Hydrogen in HD Process of NdFeB Alloy

工程科学与技术, 2011
:Abstract: In order to investigate the phenomenon of hydrogen absorption and decrepitation of NdFeB alloy, the diffusion time of hydrogen in HD process of NdFeB alloy was theoretically calculated with the Fick diffusion equation.
Yang Gang
doaj  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source