Results 81 to 90 of about 219,729 (312)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Self-modulated hydrogen electrocatalysis on sub-2-nm platinum nanoparticles by in situ generated surface hydrides

Nature Communications
Revealing the surface structure evolution under working conditions is crucial for understanding the activity and stability of electrocatalysts. Platinum, the state-of-the-art electrocatalyst for hydrogen oxidation in fuel cells or hydrogen evolution in ...
Liang Chang, Yangfan Shao, Linqing Miao, Yuyuan Jiang, Qingqing Lu, Sijie Wang, Feiyu Kang, Jia Li, Lin Gan   +8 more
doaj   +1 more source

Vertically Aligned Ultrathin 1T-WS2 Nanosheets Enhanced the Electrocatalytic Hydrogen Evolution

Nanoscale Research Letters, 2018
Efficient evolution of hydrogen through electrocatalysis holds tremendous promise for clean energy. The catalytic efficiency for hydrogen evolution reaction (HER) strongly depends on the number and activity of active sites. To this end, making vertically
Qunying He, Longlu Wang, Kai Yin, Shenglian Luo   +3 more
doaj   +1 more source

Understanding of the intensified effect of super gravity on hydrogen evolution reaction

, 2009
Hydrogen evolution reaction (HER) under super gravity field was studied in 0.5 M H(2)SO(4) aqueous solution by cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry and electrochemical impedance spectroscopy (EIS).
Wang, Zhi, Wang, MY, Wang, Mingyong, Guo, Zhancheng   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Hydrogen Oxidation and Hydrogen Evolution on a Platinum Electrode in Acetonitrile

ChemElectroChem, 2015
AbstractThis work discusses the kinetics of the hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) on a polycrystalline platinum electrode in acetonitrile, in presence of two different electrolytes. Our findings indicate the sensitivity of the kinetics of these reactions to the presence of small amounts of water.
Ledezma Yanez, I.D., Diaz Morales, O.A., Costa Figueiredo, M.C., Koper, M.T.M.   +3 more
openaire   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Efficient and stable visible-light-driven Z-scheme overall water splitting using an oxysulfide H2 evolution photocatalyst

Nature Communications
So-called Z-scheme systems permit overall water splitting using narrow-bandgap photocatalysts. To boost the performance of such systems, it is necessary to enhance the intrinsic activities of the hydrogen evolution photocatalyst and oxygen evolution ...
Lihua Lin, Yiwen Ma, Junie Jhon M. Vequizo, Mamiko Nakabayashi, Chen Gu, Xiaoping Tao, Hiroaki Yoshida, Yuriy Pihosh, Yuta Nishina, Akira Yamakata, Naoya Shibata, Takashi Hisatomi, Tsuyoshi Takata, Kazunari Domen   +13 more
doaj   +1 more source

Short Review: Cu Catalyst for Autothermal Reforming Methanol for Hydrogen Production [PDF]

, 2012
Hydrogen is a promising alternative energy sources, hydrogen can be used in fuel cell applications to pro-ducing electrical energy and water as byproduct.
Ho-Shing Wu, Lesmana, Donny, Wu, Ho-Shing, Donny Lesmana   +3 more
core   +1 more source