Results 281 to 290 of about 360,534 (337)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Serrated Leaf‐Like N‐Doped Copper Sulfide Enabling Bifunctional Oxygen Reduction/Evolution via Dual‐Mode Cathode Reactions for High Energy Density and Cycle Stability in Zinc–Air Batteries

open access: yesAdvanced Science, EarlyView.
A serrated leaf‐like nitrogen‐doped copper sulfide (N‐CuS) cathode with hybridized N 2p – S 3p orbitals is presented, mesopores for oxygen transport, and a five times larger electrochemical active surface area than Cu. In aerobic conditions, a zinc–air battery with N‐CuS achieves 788 mAh g⁻¹ and 916 Wh kg⁻¹, outperforming Pt/C+RuO₂.
Do Hwan Jung   +8 more
wiley   +1 more source

Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect

open access: yesAdvanced Science, EarlyView.
Due to the synergistic effect of ENernst,H2O2${E}_{\mathrm{Nernst},\ {\mathrm{H}}_{2}{\mathrm{O}}_{2}}$ and ENernst,H+${E}_{\mathrm{Nernst},\ {\mathrm{H}}^{+}}$, the proposed sensors in this study can achieve ultralow H2O2 detection limit as low as 1.8 × 10−12 M based on the stacked PEDOT: BTB/PEDOT: PSS semiconducting layer.
Zhaoqun Wang   +12 more
wiley   +1 more source

Development of a virulent O'nyong'nyong challenge model to determine heterologous protection mediated by a hydrogen peroxide-inactivated chikungunya virus vaccine. [PDF]

open access: yesPLoS Negl Trop Dis
Weber WC   +13 more
europepmc   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

open access: yesAdvanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang   +4 more
wiley   +1 more source

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

open access: yesAdvanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen   +10 more
wiley   +1 more source

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