Results 61 to 70 of about 1,390,857 (294)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Parametric study on the heating values of products as via steam gasification of palm waste using CaO as sorbent material [PDF]

, 2016
In Malaysia, due to abundance of oil palm waste, it is a good candidate to be used as a feedstock for syngas and hydrogen production. Biomass steam gasification is one of the promising methods for syngas production.
Ahmad, Murni Melati, Inayat, Abrar, Khan, Zakir, Mutalib, Mohamed Ibrahim Abdul, Yusup, Suzana   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Analysis of Hydrogen Production Potential Based on Resources Situation in China [PDF]

E3S Web of Conferences, 2019
Hydrogen energy is becoming more and more blooming because of its diversified sources, eco-friendly and green, easy storage and transportation, high-efficient utilization, etc.
Yang Yanmei, Wang Geng, Lin Ling, Zhang Sinan   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Biogas upgrading towards acetic acid production using Clostridium thailandense supplemented with granular activated carbon (GAC) and L-arginine: A genomic analysis approach

Carbon Resources Conversion
This study explores the impact of granular activated carbon (GAC) and L-arginine supplementation on biogas upgrading and acetic acid production employing Clostridium thailandense.
Srisuda Chaikitkaew, Nantharat Wongfaed, Chonticha Mamimin, Sompong O-Thong, Alissara Reungsang   +4 more
doaj   +1 more source

Suppressing diborane production during the hydrogen release of metal borohydrides: The example of alloyed Al(BH$_4$)$_3$

, 2016
Aluminum borohydride (Al(BH$_4$)$_3$) is an example of a promising hydrogen storage material with exceptional hydrogen densities by weight and volume and a low hydrogen desorption temperature.
Harrison, D., Thonhauser, T.
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrated anaerobic membrane bioreactor-yeast biorefinery for co-production of hydrogen, volatile fatty acids, and microbial oil from food waste

Scientific Reports
With growing food waste challenges globally, acidogenic fermentation using an anaerobic membrane bioreactor (AnMBR) was developed for the co-production of hydrogen, volatile fatty acids (VFAs), and microbial oil from food waste.
Prawat Sukphun, Panitan Jutaporn, Alissara Reungsang   +2 more
doaj   +1 more source

Conversion of carbon dioxide in biogas into acetic acid by Clostridium thailandense immobilized on porous support materials

Heliyon
This study aimed to convert CO2 in biogas into acetic acid using immobilized Clostridium thailandense cells on various support materials, including activated carbon, expanded clay, and coir.
Srisuda Chaikitkaew, Nantharat Wongfaed, Chonticha Mamimin, Sompong O-Thong, Alissara Reungsang   +4 more
doaj   +1 more source