Results 61 to 70 of about 488,017 (297)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Ab initio study of beryllium-decorated fullerenes for hydrogen storage

, 2010
We have found that a beryllium (Be) atom on nanostructured materials with H2 molecules generates a Kubas-like dihydrogen complex [H. Lee et al. arXiv:1002.2247v1 (2010)].
Duan, Wenhui, Huang, Bing, Ihm, Jisoon, Lee, Hoonkyung   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Electrochemical alcohol oxidation reaction on Precious‐Metal‐Free catalysts: Mechanism, activity, and selectivity

Carbon Neutralization
The electrochemical alcohol oxidation reaction (AOR) is pivotal for the development of sustainable energy. The complete oxidation of alcohols has attracted extensive attention as a vital process in fuel cells.
Jiawei Shi, Jun Ma, Enze Ma, Jing Li, Yang Hu, Liyuan Fan, Weiwei Cai   +6 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Synthesis of titanium decorated graphene for renewable energy applications [PDF]

, 2014
Reduced graphene oxide (RGO) was prepared from natural graphite by Hummers method. Few layers graphene was decorated with titanium by an incipient wetness impregnation method.
A Ambrosi, A Felten, A Lebon, B Saner, BP Vinayan, CC Huang, CH Chen, G Compagnini, G Srinivas, H Liu, H Poh, H Yoshitake, HC Choi, HP Zhang, JM Kim, K Li, K Spyrou, K Ullah, M Giovanni, MC Biesingera, MI Rojas, P Wang, VB Parambhath, W Hong, X Wang, Y Wang, YW Liu   +26 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mesoporous Silica‐Based Photocatalytic Materials for Solar Energy Storage and Utilization

Carbon Energy
The efficient storage and application of sustainable solar energy has drawn significant attention from both academic and industrial points of view.
Rui Sun, Yaqi Wu, Ning Han, Liang Chen, Zhangxing Chen, Heng Zhao   +5 more
doaj   +1 more source

Effect of alloying elements in melt spun Mg-alloys for hydrogen storage [PDF]

, 2016
In this paper we report the effect of alloying elements on hydrogen storage properties of melt-spun Mg-based alloys. The base alloys Mg90Si10, Mg90Cu10, Mg65Cu35 (at%) were studied.
Audebert, Fernando Enrique, Botta, Pablo Martín, Eckert, Jürgen, Huot, Jacques, Lang, Julien, Rozenberg, Silvia, Saporiti, María Fabiana Sonia, Stoica, Mihai   +7 more
core   +1 more source