Results 21 to 30 of about 1,249,304 (294)

Facile Solvent-Free Preparation of Antioxidant Idebenone-Loaded Nanoparticles for Efficient Wound Healing

Pharmaceutics, 2022
The excessive production of reactive oxygen species (ROS) causes harmful effects, including biomolecular damage and inflammation. ROS due to ultraviolet rays, blue light, and fine dust harm the skin, causing urban-related aging.
HeeSeon Yang, Sohyeon Yu, Jisu Kim, KumJu Baek, Young-Ran Lee, Hye Sun Lee, Won Il Choi, Daekyung Sung   +7 more
doaj   +1 more source

In vitro evaluation of the inhibitory potential of pharmaceutical excipients on human carboxylesterase 1A and 2.

PLoS ONE, 2014
Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11).
Chengliang Zhang, Yanjiao Xu, Qiaoni Zhong, Xiping Li, Ping Gao, Chengyang Feng, Qian Chu, Yuan Chen, Dong Liu   +8 more
doaj   +1 more source

Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid–Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

Pharmaceutics, 2021
The methacrylic acid–ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume,
Omar Rodrigo Guadarrama-Escobar, Ivonne Sánchez-Vázquez, Pablo Serrano-Castañeda, German Alberto Chamorro-Cevallos, Isabel Marlen Rodríguez-Cruz, Adalí Yisell Sánchez-Padrón, Ericka Anguiano-Almazán, Ma. Concepción Peña-Juárez, Abraham Méndez-Albores, Clara Luisa Domínguez-Delgado, Crisóforo Mercado-Márquez, Betsabé Rodríguez-Pérez, José Juan Escobar-Chávez   +12 more
doaj   +1 more source

Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs)

Pharmaceuticals, 2022
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid SNEDDS that comprises RMP and black seed oil (as a natural source of THQ) could lead to ...
Ahmad Abdul-Wahhab Shahba, Abdelrahman Y. Sherif, Ehab M. Elzayat, Mohsin Kazi   +3 more
doaj   +1 more source

Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

Asian Journal of Pharmaceutical Sciences, 2018
The development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs is usually based on traditional one-factor-at-a-time approaches.
Thuy Tran, Thomas Rades, Anette Müllertz   +2 more
doaj   +1 more source

Tadalafil-Loaded Self-Nanoemulsifying Chewable Tablets for Improved Bioavailability: Design, In Vitro, and In Vivo Testing

Pharmaceutics, 2022
This research aimed to develop innovative self-nanoemulsifying chewable tablets (SNECT) to increase oral bioavailability of tadalafil (TDL), a nearly insoluble phosphodiesterase-5 inhibitor.
Hany S. M. Ali, Sameh A. Ahmed, Abdulmalik A. Alqurshi, Ali M. Alalawi, Ahmed M. Shehata, Yaser M. Alahmadi   +5 more
doaj   +1 more source

Reply to Israel Carmi (2002): “Are the 14C Dates of the Dead Sea Scrolls Affected by Castor Oil Contamination?” [PDF]

, 2003
The Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries.
Strugnell, John, Plicht, Johannes van der, van der Plicht, Johannes, Strugnell, John,, Doudna, Gregory, Cross, Frank M., Rasmussen, Kaare L.,, Rasmussen, Kaare L., Cross, Frank M.,, Doudna, Gregory,, Plicht, Johannes van der,   +10 more
core   +2 more sources

Studies on High Pressure Hydrogenation of the Castor oil

Nippon Nōgeikagaku Kaishi, 1937
(1) 蓖麻子油の高壓水素添加法によるOctadecandiol (1, 12)の生成を證しコバルト觸媒による場合反應温度220～235°Cを以て好適なりと認めた. (2) 純Octadecandiol酸エステル曹達鹽を調製し之が諸性状特に諸種濃度の水溶液につき粘度界面張力等の測定を行つた.之等の性質は温度の變化により著しき影響を認めず,同一炭素の正アルコホルの硫酸エステル曹達鹽に比し水に對する溶解度著しく大なる特徴あるも浸透剤としての他の性質は概して稍劣ることを認めた.
SHINOZAKI, Yuichi, KAGAWA, Sanroku
  +7 more sources

The preparation and relative bioavailability of an artemisin in self-emulsifying drug delivery system

Drug Delivery, 2023
The aim of this study is to demonstrate a method for improving the solubility and relative bioavailability of artemisinin using a self-emulsifying drug delivery system (SEDDS). The self-emulsifying drug load, solubility, and emulsifying time were used as
Sijia Gao, Jingcai Chen, Wanqian Peng, Yang Yang, Yong Yang, Lei Hua, Yanlei Guo, Yunhong Wang, Xiaomei Zhang   +8 more
doaj   +1 more source

Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel

Brazilian Journal of Pharmaceutical Sciences, 2010
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility.
Marco Vinicius Chaud, Pollyanna Tamascia, Andréa Cristina de Lima, Maria Ondina Paganelli, Maria Palmira Daflon Gremião, Osvaldo de Freitas   +5 more
doaj   +1 more source