Results 21 to 30 of about 1,747 (248)

Oil–water partition coefficient preparation and detection in the dihydroartemisinin self-emulsifying drug delivery system

BMC Biotechnology, 2022
Background The aim of the present study is to increase the solubility of dihydroartemisinin (DHA) using the self-emulsifying drug delivery system (SEDDS).
Yunhong Wang, Jingcai Chen, Yang Yang, Sijia Gao, Zhuzhu Wang, Yating Liu, Xiaomei Zhang, Lei Hua, Yanlei Guo, Yong Yang   +9 more
doaj   +1 more source

Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid–Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

Pharmaceutics, 2021
The methacrylic acid–ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume,
Omar Rodrigo Guadarrama-Escobar, Ivonne Sánchez-Vázquez, Pablo Serrano-Castañeda, German Alberto Chamorro-Cevallos, Isabel Marlen Rodríguez-Cruz, Adalí Yisell Sánchez-Padrón, Ericka Anguiano-Almazán, Ma. Concepción Peña-Juárez, Abraham Méndez-Albores, Clara Luisa Domínguez-Delgado, Crisóforo Mercado-Márquez, Betsabé Rodríguez-Pérez, José Juan Escobar-Chávez   +12 more
doaj   +1 more source

In vitro evaluation of the inhibitory potential of pharmaceutical excipients on human carboxylesterase 1A and 2.

PLoS ONE, 2014
Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11).
Chengliang Zhang, Yanjiao Xu, Qiaoni Zhong, Xiping Li, Ping Gao, Chengyang Feng, Qian Chu, Yuan Chen, Dong Liu   +8 more
doaj   +1 more source

Combined Ramipril and Black Seed Oil Dosage Forms Using Bioactive Self-Nanoemulsifying Drug Delivery Systems (BIO-SNEDDSs)

Pharmaceuticals, 2022
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid SNEDDS that comprises RMP and black seed oil (as a natural source of THQ) could lead to ...
Ahmad Abdul-Wahhab Shahba, Abdelrahman Y. Sherif, Ehab M. Elzayat, Mohsin Kazi   +3 more
doaj   +1 more source

Rheology of Aqueous Dispersions of Hydrogenated Castor Oil

Applied Rheology, 2013
Three major hydrogenated castor oil crystal morphologies have been observed: fiber, rosette and irregular crystal. Due to the difficulty in obtaining samples with a single crystal morphology, rheological studies of suspensions containing mixtures of the ...
Yang Dingzheng, Hrymak Andrew N.
doaj   +1 more source

Tadalafil-Loaded Self-Nanoemulsifying Chewable Tablets for Improved Bioavailability: Design, In Vitro, and In Vivo Testing

Pharmaceutics, 2022
This research aimed to develop innovative self-nanoemulsifying chewable tablets (SNECT) to increase oral bioavailability of tadalafil (TDL), a nearly insoluble phosphodiesterase-5 inhibitor.
Hany S. M. Ali, Sameh A. Ahmed, Abdulmalik A. Alqurshi, Ali M. Alalawi, Ahmed M. Shehata, Yaser M. Alahmadi   +5 more
doaj   +1 more source

Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

Asian Journal of Pharmaceutical Sciences, 2018
The development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs is usually based on traditional one-factor-at-a-time approaches.
Thuy Tran, Thomas Rades, Anette Müllertz   +2 more
doaj   +1 more source

The preparation and relative bioavailability of an artemisin in self-emulsifying drug delivery system

Drug Delivery, 2023
The aim of this study is to demonstrate a method for improving the solubility and relative bioavailability of artemisinin using a self-emulsifying drug delivery system (SEDDS). The self-emulsifying drug load, solubility, and emulsifying time were used as
Sijia Gao, Jingcai Chen, Wanqian Peng, Yang Yang, Yong Yang, Lei Hua, Yanlei Guo, Yunhong Wang, Xiaomei Zhang   +8 more
doaj   +1 more source

Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain

Drug Delivery, 2021
The majority of newly developed drugs need to be incorporated with delivery systems to maximize their effect and minimize side effects. Nanoemulsions (NEs) are one type of delivery system that helps to improve the solubility and dissolution of drugs ...
Khaled M. Hosny, Amal M. Sindi, Hala M. Alkhalidi, Mallesh Kurakula, Amira H. Hassan, Rana B. Bakhaidar, Walaa A. Abualsunun, Alshaimaa M. Almehmady, Ahmed Khames, Waleed Y. Rizg, Rasha A. Khallaf, Nabil K. Alruwaili, Nabil A. Alhakamy   +12 more
doaj   +1 more source

Evaluation of a Hydrophobic–Hydrophilic (Hydrogenated Castor Oil-Gum Tragacanth) Matrix using Propranolol Hydrochloride as Test Drug

, 2008
An evaluation of propranolol hydrochloride release from hydrogenated castor oil–gum tragacanth matrices was carried out. The pH of the dissolution medium was found to affect propranolol hydrochloride release from such matrices.
PR Chinopfukutwa, RTJ Chigwanda, Chigwanda, RTJ, Chinopfukutwa, PR   +3 more
core   +1 more source