Results 131 to 140 of about 157,550 (314)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides

Angewandte Chemie International Edition, EarlyView.
A multienzyme was formed and evaluated by covalently linking 4‐coumarate ligase (4CL1) from Piper methysticum to a non‐reducing murine fatty acid synthase. 4CL1 acylates the acyl carrier protein (ACP). The ketosynthase (KS) was engineered to accept the non‐native cinnamoyl substrate, which is elongated by malonyl‐CoA loaded via the malonyl‐acetyl ...
Felix Lehmann, Nadja Joachim, Carolin Parthun, Martin Grininger   +3 more
wiley   +1 more source

Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics

Angewandte Chemie International Edition, EarlyView.
Pseudotetraivprolide is a new player among the Detoxin/Rimosamide‐like natural products! Its biosynthesis requires FabD from primary metabolism and a PipDFG complex for final‐step acetylation – unlocking its anti‐antibotic activity. Abstract Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis ...
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

, 2012
Christophe Morisseau, Bruce D. Hammock
openalex   +2 more sources

Bacillus subtilis CwlP of the SP-β Prophage Has Two Novel Peptidoglycan Hydrolase Domains, Muramidase and Cross-linkage Digesting dd-Endopeptidase [PDF]

, 2010
I Putu Sudiarta, Tatsuya Fukushima, Junichi Sekiguchi   +2 more
openalex   +1 more source

Characterisation of the N‐Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines

Angewandte Chemie International Edition, EarlyView.
The N‐methyltransferase SgPsmC was characterised and applied in the kinetic resolution (KR) of easily obtainable pyrroloindolines. Substitution at 3a‐position proved to be a principal determinant for the enzyme's enantioselectivity. While moving toward laboratory scale, the reaction was coupled with a methionine adenosyl transferase for in situ ...
Benjamin Panagiotis Chapple, Lia Nitz, Pascal Schneider, Birgit Henßen, Sebastian Myllek, Mona Haase, Thomas Classen, Jörg Pietruszka   +7 more
wiley   +1 more source

Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3 [PDF]

, 2009
Katerina Artavanis‐Tsakonas, Wilhelm A. Weihofen, John M. Antos, Bradley I. Coleman, Christy Comeaux, Manoj T. Duraisingh, Rachelle Gaudet, Hidde L. Ploegh   +7 more
openalex   +1 more source

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors

, 2012
Mitsunori Kono, Takahiro Matsumoto, Tōru Kawamura, Atsushi Nishimura, Yoshihiro Kiyota, Hideyuki Oki, Junichi Miyazaki, S. Igaki, Craig A. Behnke, Masato Shimojo, Masakuni Kori   +10 more
openalex   +1 more source

Peptide hydrolases in the brush border and soluble fractions of small intestinal mucosa of rat and man [PDF]

, 1972
Y. S. Kim, W. Birtwhistle, Y. W. Kim
openalex   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Tasha K. Phillips, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +16 more
wiley   +1 more source