Results 131 to 140 of about 297,801 (378)
Angewandte Chemie, EarlyView.Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, results from the fusion of two individual polyketide chains. The noncanonical condensation domain of the PKS–NRPS hybrid synthetase BurF forms an ester bond, and the terminal reductase domain mediates a reductive chain release followed ...
Jonas Fiedler +5 more
wiley +2 more sources
Advanced Science, EarlyView.ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen +17 more
wiley +1 more source
Unlocking Lactonase Enzymes as Biocatalysts for the Deracemisation of Chiral γ‐Thiolactones
Angewandte Chemie, EarlyView.The application of lactonase enzymes as biocatalysts still remains underexplored. This study discloses the biocatalytic activity of two lactonases in the deracemisation of chiral C3‐substituted‐γ‐thiolactones. The biocatalyst GcL catalyses the enzymatic kinetic resolution (EKR) of C3‐amide‐thiolactones, while the rationally engineered biocatalyst N9 ...
Jingyue Wu +7 more
wiley +2 more sources
Frontiers in Earth SciencePhenolic compounds have been proposed to influence decomposition by inhibiting extracellular enzyme activities, as described in the enzymic latch mechanism (ELM).
Talal Asif +5 more
doaj +1 more source
Epoxides and soluble epoxide hydrolase in cardiovascular physiology.
Physiological Reviews, 2012 Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that ...
J. Imig
semanticscholar +1 more source
Genetic Impacts on the Structure and Mechanics of Cellulose Made by Bacteria
Advanced Science, EarlyView.A genetic mutation in a protease of a cellulose‐overproducing evolved bacterium significantly affects the proteome, structure, and mechanical properties of bio‐fabricated cellulose pellicles. By overexpressing synthase proteins that build the cellulose‐forming biological machinery of the cell, the evolved bacterium generates dense, stiff, and strong ...
Julie M. Laurent +8 more
wiley +1 more source
Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering
Angewandte Chemie, EarlyView.This work uncovers molecular determinants of cold adaptation in bidomain amylases by combining MD simulations and biochemical assays, revealing that increased domain separation drives enhanced activity at low temperatures. Guided by this principle, high‐throughput in silico linker screening of mesophilic psA was performed, yielding variant psA121 with ...
Ning Ding +6 more
wiley +2 more sources
mAbsMonoclonal antibodies (mAb) and other biological drugs are affected by enzymatic polysorbate (PS) degradation that reduces product stability and jeopardizes the supply of innovative medicines.
Melanie Maier +15 more
doaj +1 more source
Diversity of glycosyl hydrolase enzymes from metagenome and their application in food industry.
Journal of Food Science, 2014 Traditional use of enzymes for food processing and production of food ingredients resulted in fast-growing enzyme industries world over. The advances in technologies gave rise to exploring newer enzymes and/or modified enzymes for specific application ...
T. A. Sathya, Mahejibin Khan
semanticscholar +1 more source
An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance
Advanced Science, EarlyView.This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue +9 more
wiley +1 more source