Results 121 to 130 of about 102,009 (244)

Integrierte elektromikrobielle Produktion von Itaconsäure aus CO2 im Litermaßstab unter Verwendung von Komagataella phaffii

Angewandte Chemie, EarlyView.
Die Studie stellt ein neuartiges Hybridsystem vor, das die elektrochemische CO2‐Reduktion mit mikrobieller Biosynthese in einem Reaktor verbindet. Mithilfe einer synthetisch autotrophen Hefe wird CO2 zur Herstellung von Itaconsäure genutzt. Unter Nutzung einer Industriehefe zeigen wir das Potenzial dieses Ansatzes für die direkte Umwandlung von CO2 in ...
Paniz Izadi, Manja M. Severinsen Zijlstra, Aykut Kas, Philip Haus, Verena Enzinger, Gregor Lutz, Özge Ata, Simone Bachleitner, Diethard Mattanovich, Falk Harnisch   +9 more
wiley   +1 more source

Biokatalysatoren für die Geranylierung von Peptiden mit Linearen und Zyklischen Prenylgruppen

Angewandte Chemie, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids ...
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source

Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis [PDF]

, 2010
Many pathogenic microorganisms invade mammalian and/or plant cells by producing polysaccharide-degrading enzymes (lyases and hydrolases). Mammalian glycosaminoglycans and plant pectins that form part of the cell surface matrix are typical targets for ...
Itoh, Takafumi, Murata, Kousaku, Hashimoto, Wataru, Maruyama, Yukie, Mikami, Bunzo   +4 more
core  

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Integrated Electromicrobial Production of Itaconic Acid From CO2 at Liter‐Scale Using Komagataella phaffii

Angewandte Chemie International Edition, EarlyView.
This study demonstrates a novel hybrid system that integrates electrochemical CO2 reduction with microbial biosynthesis in a single reactor, using a synthetic autotrophic yeast to produce itaconic acid from CO2. Using an industrial yeast provides feasibility of direct electromicrobial CO2 conversion to bio‐based building blocks while identifying key ...
Paniz Izadi, Manja M. Severinsen Zijlstra, Aykut Kas, Philip Haus, Verena Enzinger, Gregor Lutz, Özge Ata, Simone Bachleitner, Diethard Mattanovich, Falk Harnisch   +9 more
wiley   +1 more source

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

Angewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source

A Metagenome‐Assembled Genome Catalog From the Global Ruminant Microbiomes

Animal Research and One Health, EarlyView.
The Ruminant Gastrointestinal MAG Catalog (RGMC) is a comprehensive global resource offering 40,812 strain‐level genomes across 53 bacterial and 4 archaeal classes. It greatly surpasses prior efforts in scale and diversity, serving as an essential foundation for research in ruminant nutrition, microbial function, and methane mitigation.
Shizhe Zhang, Qiushuang Li, Bingzi Ouyang, Wenxing Wang, Xiang Zhou, Xiumin Zhang, Rong Wang, Zhiliang Tan, Min Wang   +8 more
wiley   +1 more source

Enzymatic Resolution of Ethyl 3-Hydroxy-3-Phenylpropanoate and Analogs using Hydrolases

Journal of the Brazilian Chemical Society, 2001
This work contributes to the substrate model study of enzymatic hydrolysis of secondary and tertiary beta-hydroxy esters. One secondary and four tertiary beta-hydroxy esters have been employed with PCL, PLE, CRL and AOP enzymes.
Ribeiro Carlos M. R., Passaroto Elisa N., Brenelli Eugênia C. S.   +2 more
doaj  

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Metagenomic insights into potential PET hydrolases from Antarctic soils and rhizospheres. [PDF]

Front Microbiol
Berríos-Farías V, Guajardo-Leiva S, Gallardo-Cerda J, Galbán-Malagón C, Egas C, Molina-Montenegro MA, Castro-Nallar E.   +6 more
europepmc   +1 more source