Results 131 to 140 of about 102,009 (244)

Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen, Zhenjiang An, Yingying Jiang, Zijian Huang, Kunlin Chen, Yundong Gao, Jianbin Li, Shuwen Xia, Huili Wang   +8 more
wiley   +1 more source

Protein Abundance of Hydrolytic Drug Metabolizing Enzymes in Different Tissues and across Species. [PDF]

J Med Chem
Subash S, Ahire D, Jones RS, Ma B, Tian Y, Wang T, Khojasteh SC, Murray BP, Stresser DM, Taub M, Prasad B.   +10 more
europepmc   +1 more source

Biochemical Studies and Production Optimization of β‐Glucosidase From Microcystis aeruginosa CACIAM 03 Using Organic Waste

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Global warming and industrial pollutants pose significant threats to environmental sustainability. In response, enzymes have emerged as promising tools for mitigating pollution. Enzymatic hydrolysis is considered environmentally sustainable due to its biological nature.
Gustavo Marques Serra, Matheus Silva da Fonseca Diniz, Evonnildo Costa Gonçalves, Agenor Valadares Santos, Luciana Pereira Xavier   +4 more
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity-Stability Trade-Offs by Site-Selective CH → N Substitutions. [PDF]

Angew Chem Int Ed Engl
Abdelkader EH, Qianzhu H, Otting G, Huber T.   +3 more
europepmc   +1 more source

Valorization of Textile Waste: Enzymatic Upcycling of Terephthalic Acid Toward a Sustainable PET Value Chain

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT The rapid expansion of the global textile industry, driven by the fast‐fashion paradigm, which is characterized by low‐cost, short‐lived garments made from inexpensive synthetic fibers, has intensified environmental pressures through increased waste generation, resource depletion, microplastic pollution, and greenhouse gas emissions ...
Fares Al‐Ostoot, Loredano Pollegioni, Elena Rosini   +2 more
wiley   +1 more source

Genome-Resolved Metagenomics Reveals Thermophilic Microbial Diversity and Putative Hydrolase-Encoding Genes in the El Tatio Geothermal Field. [PDF]

Int J Mol Sci
Valenzuela B, Navarrete-Diaz I, Cayo M, Solís-Cornejo F, Zamorano P.   +4 more
europepmc   +1 more source

Modeling Substrate-Enzyme Interactions in Fungal Hydrolases

, 2011
Computational tools play an important role in the description of biological systems. Scientists describe and study structure, conformational changes and interactions between molecules in silico, often as a cheaper and faster alternative for biosynthesis.
KULIK, Natallia
core  

Biobased Sunflower Stalk Matrix for Lipase Stabilization via Physical Adsorption

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT The search for sustainable, cost‐effective biocatalytic processes has driven efforts to develop low‐cost supports for enzyme immobilization. Lignocellulosic residues have received particular attention due to their abundance, renewability, and structural properties.
Jaci L. Vilanova Neta, Larissa O. Jesus, Sande A. S. Costa, Edélvio B. Gomes, Rita C. M. Miranda, Daniel P. Silva, Denise S. Ruzene, Cleide M. F. Soares, Álvaro S. Lima   +8 more
wiley   +1 more source

Unnatural C6-Substituted d-Galactosides as Attenuated Substrates of Glycosyl Hydrolases. [PDF]

Chembiochem
Plodukhin AY, Hernández K, Demirovic S, Ogunmilade T, Mercado BQ, Kennedy M, Angeles-Boza A, Planas A, Peczuh MW.   +8 more
europepmc   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source