Results 81 to 90 of about 151,216 (363)

AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs

Nature Chemical Biology, 2016
Enzyme classes may contain outlier members that share mechanistic, but not sequence or structural relatedness with more common representatives. The functional annotation of such exceptional proteins can be challenging.
W. Parsons, Matthew J. Kolar, Siddhesh S. Kamat, A. Cognetta, Jonathan J. Hulce, E. Saez, B. Kahn, A. Saghatelian, B. Cravatt   +8 more
semanticscholar   +1 more source

Synthetic Mucus Biomaterials Synergize with Antibiofilm Agents to Combat Pseudomonas aeruginosa Biofilms

Advanced Therapeutics, EarlyView.
Mucus‐inspired biomaterials are developed that inhibit biofilm formation and enhance dispersal when combined with DNase and/or α‐amylase. The combination led to up to 2‐log reductions in biofilm viability, offering a promising alternative to traditional antibiotics for treating persistent, antibiotic‐resistant infections.
Sydney Yang, Allison Boboltz, Alexa Stern, Vaidehi Rathi, Gregg Duncan   +4 more
wiley   +1 more source

Exploiting the Unique Properties of Lanthanide Complexes as FRET Probes: from Quantitation to Protein Dynamics

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Lanthanide complexes are ideal donors for FRET (Förster resonance energy transfer) assays with a variety of applications from easy‐to‐use quantitation of proteins to sophisticated experiments giving real‐time information on the movement of proteins. This Review article introduces the principles of using such assays before surveying the full scope of ...
Simon Wheeler, Stephen J. Butler
wiley   +1 more source

In silico modeling of the molecular structure and binding of leukotriene A4 into leukotriene A4 hydrolase [PDF]

arXiv, 2012
A combined molecular docking and molecular structure in silico analysis on the substrate and product of leukotriene A4 hydrolase (LTA4H) was performed. The molecular structures of the substrate leukotriene A4 (LTA4) and product leukotirene B4 (LTB4) were studied through Density Functional Theory (DFT) calculations at the B3LYP/6-31+G(d) level of theory
arxiv  

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.

ACS Chemical Biology, 2017
The biosynthetic and catabolic enzymes of the endocannabinoids tightly regulate endocannabinoid-mediated activation of the cannabinoid CB1 receptor. Monitoring the activities of these endocannabinoid hydrolases in different brain regions is, therefore ...
M. Baggelaar, Annelot C. M. van Esbroeck, Eva J. van Rooden, B. Florea, H. Overkleeft, G. Marsicano, F. Chaouloff, Mario van der Stelt   +7 more
semanticscholar   +1 more source

Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration

Advanced Therapeutics, EarlyView.
Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana, Samartha M C, Ashwath Acharya, Goutam Thakur, Manasa Nune, Vipul Agarwal   +5 more
wiley   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Halophilic Bacteria as a Source of Novel Hydrolytic Enzymes

Life, 2013
Hydrolases constitute a class of enzymes widely distributed in nature from bacteria to higher eukaryotes. The halotolerance of many enzymes derived from halophilic bacteria can be exploited wherever enzymatic transformations are required to function ...
Encarnación Mellado, María Teresa García, Dolores Pérez, María de Lourdes Moreno   +3 more
doaj   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Chitinase Activities in Wheat and Its Relative Species

Agriculture, 2017
Defense components such as chitinases (EC 3.2.1.14) are crucial for plants to cope diseases. Despite of that the pattern and activities of these enzymes in agronomically important Triticale is unexplored.
Moravčíková Jana, Ujvariová Nikoleta, Žur Iwona, Gálová Zdenka, Gregorová Zuzana, Zimová Mária, Boszorádová Eva, Matušíková Ildikó   +7 more
doaj   +1 more source