Results 71 to 80 of about 775,144 (299)
Protein Denaturation Zero Entropy Temperature, and the Structure of Water Around Hydrophobic and Amphiphilic Solutes [PDF]
, 2020 The hydrophobic effect plays a key role in many chemical and biological processes, including protein folding. Nonetheless, a comprehensive picture of the effect of temperature on hydrophobic hydration and protein denaturation remains elusive.
Nuno, Galamba, kazimieras, Tamoliūnas
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Amino acids involved in the hydrophobic crevice and hydrophobic dent.
, 2015 Amino acids involved in the hydrophobic crevice and hydrophobic dent.
Alain Marty (318103) +5 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Is a Hydrophobic Material Always Hydrophobic? [PDF]
Hydrocarbons including a methylene group have been widely believed to be a hydrophobic block which induces depletion of water around it. The present study raises the question; is a methylene group always hydrophobic?
澁田, 諭
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Recent Advances in Hydrophobic Deep Eutectic Solvents for Extraction
Separations, 2019 In the over 1,800 articles published since their inception in 2001, most deep eutectic solvents (DES) synthesized have been hydrophilic. The low cost, low toxicity, and bioavailability of DES make the solvent ‘green’ and sustainable for ...
Amos K. Dwamena
doaj +1 more source
, 2013 Super-hydrophobic yolk–shell nanostructure with enhanced catalytic performance in the reduction of hydrophobic nitroaromatic ...
高进 +6 more
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