Results 51 to 60 of about 259,992 (327)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Selection strategy for encapsulation of hydrophilic and hydrophobic ingredients with food-grade materials: A systematic review and analysis

Food Chemistry: X
Various lipid and biopolymer-based nanocarriers have been developed to encapsulate food ingredients. The selection of nanocarrier type, preparation techniques, and loading methods should consider the compatibility of nutrient properties, nanocarrier ...
Ruihan Huang, Hongdong Song, Sen Li, Xiao Guan   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Experimental Study on Van der Waals Interactions Between Organic Groups of Quaternary Ammonium Salt Surfactants and Montmorillonite in Aqueous Solutions

Inorganics
Obtaining the dielectric constant and refractive index of the siloxane surface of montmorillonite (Mnt) and organic groups is difficult, limiting the study of Van der Waals (VDW) interactions between the hydrophilic end of quaternary ammonium surfactants
Yongzheng Fu, Ming Chang, Yuhao Pan, Wennan Xu, Rui Li, Wenzhao Zhu, Hongliang Li   +6 more
doaj   +1 more source

Atomic Force Microscopy Demonstrates that Candida glabrata Uses Three Epa Proteins To Mediate Adhesion to Abiotic Surfaces

mSphere, 2019
The fungal pathogen Candida glabrata can cause both mucosal and disseminated infections. Cell adhesion, a key step in colonization and infection, depends in C. glabrata primarily on the Epa family of cell adhesion proteins.
Claire Valotteau, Valeria Prystopiuk, Brendan P. Cormack, Yves F. Dufrêne   +3 more
doaj   +1 more source

Copolymer Micelles: A Focus on Recent Advances for Stimulus-Responsive Delivery of Proteins and Peptides

Pharmaceutics, 2023
Historically used for the delivery of hydrophobic drugs through core encapsulation, amphiphilic copolymer micelles have also more recently appeared as potent nano-systems to deliver protein and peptide therapeutics.
Thomas Trimaille, Bernard Verrier
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

In silico structural evaluation of short cationic antimicrobial peptides [PDF]

, 2018
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Cationic peptides with ...
Malkinson, John, Passarini, Ilaria, Rossiter, Sharon, Zloh, Mire   +3 more
core   +3 more sources

Water Interactions with Hydrophobic versus Hydrophilic Nanosilica.

Langmuir, 2018
It is well-known that interaction of hydrophobic powders with water is weak, and upon mixing, they typically form separated phases. Preparation of hydrophobic nanosilica AM1 with a relatively large content of bound water with no formation of separated ...
V. Gun’ko, V. Turov, E. Pakhlov, T. Krupska, M. Borysenko, M. Kartel, B. Charmas   +6 more
semanticscholar   +1 more source

Conserved Hydrophobic and Hydrophilic Bond Interaction Networks in ErbB Family Kinases [PDF]

Biophysical Journal, 2010
The EGFR/ErbB/HER family of kinases contains four homologous receptor tyrosine kinases that are important regulatory elements in key signaling pathways. To elucidate the atomistic mechanisms of activation in the ErbB family, we perform molecular dynamics simulations on the three members of the ErbB family with known kinase activity, EGFR, HER2 (ErbB2 ...
Shih, Andrew J., Telesco, Shannon E., Choi, Sung Hee, Lemmon, Mark A., Radhakrishnan, Ravi   +4 more
openaire   +1 more source