Results 81 to 90 of about 290,257 (273)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Nanomaterials, 2018 Cellulosic fibre-based smart materials exhibiting multiple capabilities are getting tremendous attention due to their wide application areas. In this work, multifunctional flax fabrics with piezoresistive response were developed through the combined ...
Sofia M. Costa +4 more
doaj +1 more source
Cold and Warm Denaturation of Proteins
, 2001 We introduce a simplified protein model where the water degrees of freedom appear explicitly (although in an extremely simplified fashion). Using this model we are able to recover both the warm and the cold protein denaturation within a single framework,
Caldarelli, Guido, Rios, Paolo De Los
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
IEEE AccessPolymer based composite high voltage insulators (HVIs) due to their hydrophobic surfaces have consistently outperformed the traditional ceramic insulators in highly contaminating coastal-desert environments.
Mansoor Asif +3 more
doaj +1 more source
Effect of Thai medicinal plant extracts on cell aggregation of Escherichia coli O157: H7. [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2005 Medicinal plants have been used for treating diarrhoea but the interference mechanisms are not clearly understood. One possible hypothesis is that of an effect on cell surface hydrophobicity of microbial cells. In this study, we examined cell aggregation
Limsuwan, S. +2 more
doaj
Soil and Water Research, 2008 Soil water repellency has important consequences for ecological and hydrological properties of soils and usually retards infiltration capacity and induces preferential flow. This phenomenon has been known to occur on a wide range of sites under a variety
Niels Arne Wahl
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A brief overview of the causes, impacts and amelioration of soil water repellency - a review
Soil and Water Research, 2008 This article describes the phenomenon of soil water repellency, starting from the fundamental principals of water transport and storage in soil. Soil water repellency is a reduction in the rate of wetting and retention of water in soil caused by the ...
Paul D. Hallett
doaj +1 more source
Evolvability of Chaperonin Substrate Proteins [PDF]
, 2009 Molecular chaperones ensure that their substrate proteins reach the functional native state, and prevent their aggregation. Recently, an additional function was proposed for molecular chaperones: they serve as buffers (_capacitors_) for evolution by ...
Emanuele Raineri +3 more
core +1 more source