Results 81 to 90 of about 289,831 (273)

Dry and wet interfaces: Influence of solvent particles on molecular recognition

open access: yes, 2009
We present a coarse-grained lattice model to study the influence of water on the recognition process of two rigid proteins. The basic model is formulated in terms of the hydrophobic effect.
B. Alberts   +7 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Fabrication of Hydrophobic Coatings Using Sugarcane Bagasse Waste Ash as Silica Source

open access: yesApplied Sciences, 2019
Eco-friendly hydrophobic coatings were fabricated on tiles via the drop-casting process. Sugarcane bagasse waste ash (SBA) was used as a silica source and dimethyldiethoxysilane (DMDEOS) was used as a surface functionalizing agent.
Sriharan Natarajan   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Multifunctional Flax Fibres Based on the Combined Effect of Silver and Zinc Oxide (Ag/ZnO) Nanostructures

open access: yesNanomaterials, 2018
Cellulosic fibre-based smart materials exhibiting multiple capabilities are getting tremendous attention due to their wide application areas. In this work, multifunctional flax fabrics with piezoresistive response were developed through the combined ...
Sofia M. Costa   +4 more
doaj   +1 more source

Biomolecule surface patterning may enhance membrane association

open access: yes, 2012
Under dehydration conditions, amphipathic Late Embryogenesis Abundant (LEA) proteins fold spontaneously from a random conformation into alpha-helical structures and this transition is promoted by the presence of membranes.
Browne J.   +17 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Intensification of Electric Field Stresses in Field Aged 380-kV Composite Insulators Due to Loss of Hydrophobicity

open access: yesIEEE Access
Polymer based composite high voltage insulators (HVIs) due to their hydrophobic surfaces have consistently outperformed the traditional ceramic insulators in highly contaminating coastal-desert environments.
Mansoor Asif   +3 more
doaj   +1 more source

Effect of Thai medicinal plant extracts on cell aggregation of Escherichia coli O157: H7. [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2005
Medicinal plants have been used for treating diarrhoea but the interference mechanisms are not clearly understood. One possible hypothesis is that of an effect on cell surface hydrophobicity of microbial cells. In this study, we examined cell aggregation
Limsuwan, S.   +2 more
doaj  

Variability of water repellency in sandy forest soils under broadleaves and conifers in north-western Jutland/Denmark

open access: yesSoil and Water Research, 2008
Soil water repellency has important consequences for ecological and hydrological properties of soils and usually retards infiltration capacity and induces preferential flow. This phenomenon has been known to occur on a wide range of sites under a variety
Niels Arne Wahl
doaj   +1 more source

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