Results 41 to 50 of about 30,527 (215)

Interaction of solid organic acids with carbon nanotube field effect transistors [PDF]

, 2006
A series of solid organic acids were used to p-dope carbon nanotubes. The extent of doping is shown to be dependent on the pKa value of the acids. Highly fluorinated carboxylic acids and sulfonic acids are very effective in shifting the threshold voltage
Ali Afzali, Anantram, Avouris, Bradley, Chen, Christian Klinke, Collins, Covington, Derycke, Dukovic, Eberson, Freedman, Fuhrer, Heinze, Kazaoui, Kim, Klinke, Klinke, Mann, Martel, Martel, McBee, O’Connell, Phaedon Avouris, Radosavljevic, Shimauchi, Strano, Tans, Ventura   +28 more
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The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells

Haematologica, 2010
Background Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance.
Basile Stamatopoulos, Nathalie Meuleman, Cécile De Bruyn, Alain Delforge, Dominique Bron, Laurence Lagneaux   +5 more
doaj   +1 more source

Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features

Frontiers in Chemistry, 2022
As a potent zinc chelator, hydroxamic acid has been applied in the design of inhibitors of zinc metalloenzyme, such as histone deacetylases (HDACs). A series of hydroxamic acids with HDAC inhibitory activities were subjected to the QSRR (Quantitative ...
Yiming Nie, Jia Li, Xinying Yang, Xuben Hou, Hao Fang   +4 more
doaj   +1 more source

Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-D-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro [PDF]

, 2014
Fourteen new fosmidomycin analogues with altered metal chelating groups were prepared and evaluated for inhibition of E. coli Dxr, M. tuberculosis Dxr and the growth of P. falciparum K1 in human erythrocytes.
Chofor, René, Couch, Robin D, Dowd, Cynthia S, Johny, Chinchu, Pouyez, Jenny, Risseeuw, Martijn, Van Calenbergh, Serge, Wouters, Johan   +7 more
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Silicon, endophytes and secondary metabolites as grass defenses against mammalian herbivores [PDF]

, 2014
Article Accepted Date: 30 August 2014 Acknowledgments This study was supported by the Academy of Finland (grant no. 133495 to Otso Huitu; grants no. 137909 and 110658 to Kari Saikkonen) and by the NERC (grant no. NE/F003994/1 to Xavier Lambin).
Forbes, Kristian M, Hartley, Sue, Helander, Marjo, Huitu, Otso, Julkunen-Tiitto, Riitta, Lambin, Xavier, Saikkonen, Kari, Stuart, Peter, Sulkama, Sini   +8 more
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Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

Medicine, 2022
. Introduction:. Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders.
Ji Hyun Kim, MS, Khan Hashim Ali, MS, Yong Jin Oh, PhD, Young Ho Seo, PhD, Chang Chen.   +4 more
doaj   +1 more source

A computational study of the interaction of organic surfactants with goethite α-FeO(OH) surfaces [PDF]

, 2016
We have studied the adsorption of three organic molecules onto different surfaces of goethite α−FeO(OH) using atomistic simulation techniques. New interatomic potentials for the interaction between goethite and the organic molecules were developed.
de Leeuw, Nora, Du, Zhimei, King, Helen E., Santos Carballal, David   +3 more
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A Reaction of N-Substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids

Organics, 2023
We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others ...
Bogdan A. Tretyakov, Svyatoslav Y. Gadomsky, Alexei A. Terentiev   +2 more
doaj   +1 more source

One-Pot Synthesis of Nα-Protected Amino/Peptide O-benzyl Hydroxamates and Acylaminoxy Dipeptides Employing Hydroxamic Acid [PDF]

, 2016
The direct conversion of simple and sterically hindered Nα-protected amino/peptide hydroxamic acids to O-benzyl hydroxamates employing K2CO3, tetrabutylammonium bromide and benzyl bromide is described.
Krishnamurthy, Muniyappa., Sagar, N.R., Sureshbabu, V.V.   +2 more
core   +2 more sources

Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition [PDF]

, 2014
Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and neurodegenerative diseases.
Sleiman, Sama F.
core   +1 more source