Results 41 to 50 of about 30,744 (233)

Development of QSRR model for hydroxamic acids using PCA-GA-BP algorithm incorporated with molecular interaction-based features

Frontiers in Chemistry, 2022
As a potent zinc chelator, hydroxamic acid has been applied in the design of inhibitors of zinc metalloenzyme, such as histone deacetylases (HDACs). A series of hydroxamic acids with HDAC inhibitory activities were subjected to the QSRR (Quantitative ...
Yiming Nie, Jia Li, Xinying Yang, Xuben Hou, Hao Fang   +4 more
doaj   +1 more source

Field-effect transistors assembled from functionalized carbon nanotubes

, 2006
We have fabricated field effect transistors from carbon nanotubes using a novel selective placement scheme. We use carbon nanotubes that are covalently bound to molecules containing hydroxamic acid functionality.
Appenzeller J., Auvray S., Avouris, Avouris Ph., Bachtold A., Bahr J. L., Banerjee S., Bethune D. S., Bonard J. M., Chen J., Chen Z., Cheng C., Choi K. H., Collins P. G., Cui Y., Dai H., Derycke V., Duan X., Dyke C. A., Folkers J. P., Hannon J. B., Heald C. G. R., Huang Y., Iijima S., Javey A., Jin S., Johnston D. E., Kataura H., Klinke C., Kooi S. E., Lee S. W., Lee Y. S., Lin Y. M., Martel R., McEuen P. L., Mirkin C. A., Morales A. M., Niyogi S., Perebeinos V., Radosavljevic M., Spataru C. D., Wind S. J.   +41 more
core   +1 more source

Evaluation of the properties of complexing agent-collectors of eudialyte flotation [PDF]

Vestnik MGTU, 2015
Acid-based and complexing properties of reagent-collectors (carboxylic and hydroxamic acids, styrylphosphonic acid and dialkyl ether of phosphoric acid) for flotation of zirconium-containing minerals have been studied.
Mitrofanova G.V., Ivanova V.A., Nikitina I.V.   +2 more
doaj  

A computational study of the interaction of organic surfactants with goethite α-FeO(OH) surfaces [PDF]

, 2016
We have studied the adsorption of three organic molecules onto different surfaces of goethite α−FeO(OH) using atomistic simulation techniques. New interatomic potentials for the interaction between goethite and the organic molecules were developed.
de Leeuw, Nora, Du, Zhimei, King, Helen E., Santos Carballal, David   +3 more
core   +3 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Design, synthesis, and biological evaluation of histone deacetylase inhibitor with novel salicylamide zinc binding group

Medicine, 2022
. Introduction:. Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders.
Ji Hyun Kim, MS, Khan Hashim Ali, MS, Yong Jin Oh, PhD, Young Ho Seo, PhD, Chang Chen.   +4 more
doaj   +1 more source

One-Pot Synthesis of Nα-Protected Amino/Peptide O-benzyl Hydroxamates and Acylaminoxy Dipeptides Employing Hydroxamic Acid [PDF]

, 2016
The direct conversion of simple and sterically hindered Nα-protected amino/peptide hydroxamic acids to O-benzyl hydroxamates employing K2CO3, tetrabutylammonium bromide and benzyl bromide is described.
Krishnamurthy, Muniyappa., Sagar, N.R., Sureshbabu, V.V.   +2 more
core   +2 more sources

Hydrogel Embedding of Mesenchymal Stem Cells Supports Extracellular Vesicle Production

Biotechnology and Bioengineering, EarlyView.
This study investigates the effects of 3D culture conditions on extracellular vesicle (EV) production by mesenchymal stem cells (MSCs) in a gelatin‐based hydrogel matrix (GelMA). The EVs from both conditions were found to have similar morphological, molecular, and functional properties, but 3D cultures produced more total EVs per volume.
Rachel K. Moen, Gabriella Faircloth, Nicole T. Marguerite, Mariachiara Conti, Ethan S. Lippmann, Jamey D. Young   +5 more
wiley   +1 more source

Structural Characterization of Porous Photo‐Crosslinked Hybrid Networks Based on Collagen‐Poly(Trimethylene Carbonate)

Macromolecular Materials and Engineering, EarlyView.
Hybrid networks combining natural and synthetic polymers into one network may result in networks with good bioactivity, suitable mechanical properties, and high control over degradation. This study shows that phase‐separated networks are obtained with the collagen phase acting as multifunctional crosslinks.
Agustin Rios de Anda, Anne‐Constance Macarez, Marc Ankoné, Steve Spoljaric, Lieke H. A. van Dommelen, Elly M.M. Versteeg, Toin H. van Kuppevelt, Willeke F. Daamen, Dirk W. Grijpma, André A. Poot, Bas van Bochove   +10 more
wiley   +1 more source

A Reaction of N-Substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids

Organics, 2023
We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others ...
Bogdan A. Tretyakov, Svyatoslav Y. Gadomsky, Alexei A. Terentiev   +2 more
doaj   +1 more source