Results 41 to 50 of about 30,775 (232)
Results in Chemistry, 2021 This present study reports some natural products and one hydroxamic acid synthetic compound which were previously reported as matrix metalloproteinase-9 (MMP-9) inhibitors to be evaluated for their inhibition toward severe acute respiratory syndrome ...
Maywan Hariono +6 more
doaj +1 more source
Facile Synthesis of N (alpha) -Protected Amino/Peptide Hydroxamic Acids Mediated by COMU [PDF]
, 2014 One-pot preparation of N (alpha) -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used.
Basavaprabhu, . +2 more
core +1 more source
Pharmaceutics, 2021 Hydroxamic acids are one of the most promising and actively studied classes of chemical compounds in medicinal chemistry. In this study, we describe the directed synthesis and effects of HDAC6 inhibitors.
Margarita Neganova +10 more
doaj +1 more source
Journal of Pharmacy and Pharmacology, 1964 Abstract The preparation of certain quinolines, quinazolines, quinoxalines, benzoxazines and benzothiazines containing the cyclic hydroxamic grouping is described. In vitro antibacterial activities showed that no compound had a broader spectrum of activity than the known 1,2-dihydro-1-hydroxy-2-oxoquinoline.
R T, COUTTS, D, NOBLE, D G, WIBBERLEY
openaire +2 more sources
Advanced Science, EarlyView.An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou +9 more
wiley +1 more source
Haematologica, 2010 Background Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance.
Basile Stamatopoulos +5 more
doaj +1 more source
Frontiers in Chemistry, 2022 As a potent zinc chelator, hydroxamic acid has been applied in the design of inhibitors of zinc metalloenzyme, such as histone deacetylases (HDACs). A series of hydroxamic acids with HDAC inhibitory activities were subjected to the QSRR (Quantitative ...
Yiming Nie +4 more
doaj +1 more source
Examining the PM6 semiempirical method for pKa prediction across a wide range of oxyacids [PDF]
, 2009 The pK~a~ estimation ability of the semiempirical PM6 method was evaluated across a broad range of oxyacids and compared to results obtained using the SPARC software program.
Kaya Forest +2 more
core +1 more source
A computational study of the interaction of organic surfactants with goethite α-FeO(OH) surfaces [PDF]
, 2016 We have studied the adsorption of three organic molecules onto different surfaces of goethite α−FeO(OH) using atomistic simulation techniques. New interatomic potentials for the interaction between goethite and the organic molecules were developed.
de Leeuw, Nora +3 more
core +3 more sources
Medicine, 2022 . Introduction:. Histone deacetylases (HDACs) have emerged as important therapeutic targets for various diseases, such as cancer and neurological disorders.
Ji Hyun Kim, MS +4 more
doaj +1 more source