Results 71 to 80 of about 30,527 (215)

Cobalt complexes with tripodal ligands: implications for the design of drug chaperones [PDF]

, 2012
Extensive research is currently being conducted into metal complexes that can selectively deliver cytotoxins to hypoxic regions in tumours. The development of pharmacologically suitable agents requires an understanding of appropriate ligand–metal systems
Bonnitcha, Paul D., Clegg, Jack K., Hambley, Trevor W., Hocking, Rosalie K., Kim, Byung J., Neville, Suzanne M., Turner, Peter   +6 more
core   +1 more source

Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil

Molecules, 2011
Fatty hydroxamic acid derivatives were synthesized using Lipozyme TL IM catalyst at biphasic medium as the palm kernel oil was dissolved in hexane and hydroxylamine derivatives were dissolved in water: (1) N-methyl fatty hydroxamic acids (MFHAs); (2) N ...
Sidik Silong, Mazyar Peyda, Roshanak Rafiee-Moghaddam, Anuar Kassim, Yadollah Gharayebi, Nor Azah Yusof, Hossein Jahangirian, Md Jelas Haron   +7 more
doaj   +1 more source

A minimalist chemical model of matrix metalloproteinases- Can small peptides mimic the more rigid metal binding sites of proteins? [PDF]

, 2013
In order to develop a minimalist chemical model of matrix metalloproteinases (MMPs), we synthesized a pentadecapeptide (Ac-KAHEFGHSLGLDHSK-NH2) corresponding to the catalytic zinc(II) binding site of human MMP-13.
Aguilar, Attila Jancsó, Beck, Burns, Camerman, Daignault, Dávid Árus, Farkas, Farkas, Gajda, Grossoehme, Harford, Heitzer, Högfeldt, Jancsó, Jancsó, Kaiser, Khairy, Kimura, Koike, Kolozsi, Kállay, Massova, Millhauser, Mylonas, Mylonas, Nóra Veronika Nagy, Paksi, Rabenstein, Rajkovic, Rockenbauer, Rosotti, Róbert Berkecz, Stanczak, Sternlicht, Sóvágó, Tallant, Tamás Gajda, Valensin, Valensin, Valensin, Verma, Witkowska, Zastrow, Zoroddu, Zékány, Ágnes Dancs, Árus, Ősz   +48 more
core   +1 more source

Pharmacological Effects of Anthranilic Hydroxamic Acid and Certain Other Hydroxamic Acids

Experimental Biology and Medicine, 1960
SummaryThe hydroxamate of anthranilic acid injected intraperitoneally into rats in a dose of 1.0 mg/g causes anesthesia lasting 10 hours or more. Recovery is apparently complete. One half this dose causes tranquilization and suppression of the conditioned avoidance response. The compound protects mice against twice the lethal dose of strychnine.
F. Bernheim, J. K. Stoops
openaire   +1 more source

Epigenetic treatment of solid tumours. A review of clinical trials [PDF]

, 2015
Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observe in cutaneous lymphomas represents a proof of principle that similar results may be obtained in solid tumours. Several agents that interfere
CODACCI PISANELLI, Giovanni, DE MARINIS, ELISABETTA, NERVI, Clara   +2 more
core   +2 more sources

Maize rhm1 Resistance to Bipolaris maydis Is Associated with Few Differences in Pathogenesis-Related Proteins and Global mRNA Profiles

Molecular Plant-Microbe Interactions, 2001
The maize rhm1 mutant resists Bipolaris maydis, the causal agent of Southern corn leaf blight, by producing small necrotic lesions surrounded by chlorotic haloes.
Carl R. Simmons, Susan Grant, Daniel J. Altier, Patrick F. Dowd, Oswald Crasta, Otto Folkerts, Nasser Yalpani   +6 more
doaj   +1 more source

Preparation of a Poly (Hydroxamic Acid) Ion-Exchange Resin from Poly (Ethyl Acrylate-Divinyl Benzene) Beads and its Properties. [PDF]

, 1988
A method to synthesize a poly (hydroxamic acid) chelating ion-exchange resin from poly (ethyl acrylate-divinyl benzene) and its behaviour towards some metal ions are described.
Ahmad, Zaharuddin, Wan Yunus, Wan Md Zin
core  

Computational study of radicals derived from hydroxyurea and its methylated analogues. [PDF]

, 2012
Structural and electronic properties and chemical fate of free radicals generated from hydroxyurea (HU) and its methylated analogues N-methylhydroxyurea (NMHU) and O-methylhydroxyurea (OMHU) are of utmost importance for their biological and ...
Birus, Mladen, Sakic, Davor, Vinkovic Vrcek, Ivana, Vrcek, Valerije, Zipse, Hendrik   +4 more
core   +1 more source

Enhancement of 2-hydroxy-3-naphthyl hydroxamic acid adsorption on bastnaesite and monazite surfaces using H2O2 pre-oxidation for improved flotation process

International Journal of Mining Science and Technology
Rare earth elements have been widely applied in various sectors. Bastnaesite and monazite are crucial rare earth minerals, and flotation is a vital technique for recovering fine-grained rare earth minerals and separating them from associated gangue ...
Weiwei Wang, Zhengyao Li, Anhua Zou, Kai Gao, Weiyao Zhu, Shaochun Hou, Chunlei Guo, Yuanyuan Wang   +7 more
doaj   +1 more source

Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency

Journal of Virus Eradication, 2019
Objectives: Current antiretroviral therapy can suppress HIV replication, increase CD4 count and result in increased lifespan. However, it cannot eradicate the virus due to the presence of latent provirus in cellular reservoirs, such as resting CD4+ T ...
Elleard F.W. Heffern, Rashmi Ramani, Garland Marshall, George B. Kyei   +3 more
doaj   +1 more source