Results 71 to 80 of about 30,744 (233)

Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-D-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro [PDF]

, 2014
Fourteen new fosmidomycin analogues with altered metal chelating groups were prepared and evaluated for inhibition of E. coli Dxr, M. tuberculosis Dxr and the growth of P. falciparum K1 in human erythrocytes.
Chofor, René, Couch, Robin D, Dowd, Cynthia S, Johny, Chinchu, Pouyez, Jenny, Risseeuw, Martijn, Van Calenbergh, Serge, Wouters, Johan   +7 more
core   +2 more sources

Effect of magnetic MMP removal on long‐term dentin collagen stability

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract Several matrix metalloproteinase (MMP) inhibitors have been investigated for their ability to improve dentin‐bond longevity. However, MMPs tend to reactivate over time, especially using simplified etch‐and‐rinse adhesives. This study investigated a novel magnetic removal of dentinal MMPs on bonding durability, MMP inhibition and collagen ...
Walter Zenobi, Salvatore Sauro, Davino Machado Andrade Neto, Karen Evellin Moura Cordeiro, Francisco Avelino, Diego Lomonaco, Pierre Basilio Almeida Fechine, Yu Fu Chou, Garrit Koller, Thiago Soares Porto, Victor Pinheiro Feitosa   +10 more
wiley   +1 more source

Design, Synthesis and Biological Evaluation of Hydroxamic Acid Derivatives as Potential High Density Lipoprotein (HDL) Receptor CLA-1 Up-Regulating Agents

Molecules, 2011
Trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) were reported in our recent publication as novel human high density lipoprotein (HDL) receptor CD36 and Lysosomal integral membrane protein-II Analogous-1 (CLA-1) up-regulators. As part of a
Yu Du, Yanbin Wu, Bin Hong, Yuan Yang, Xiaojian Jia, Li Wang, Xiaofang Chen   +6 more
doaj   +1 more source

Deprotective Functionalization: An Emerging Concept for Amine Reactivity

Chemistry – A European Journal, Volume 32, Issue 4, 23 January 2026.
While protecting groups are indispensable in total synthesis to avoid undesired reactivity, installation and removal of protecting groups lead to an increase in the step‐count, cost, waste production and time requirement. One approach tackling these drawbacks is deprotective functionalization, which combines deprotection and postfunctionalization in a ...
Irmgard Tiefenbrunner, Saad Shaaban, Nuno Maulide   +2 more
wiley   +1 more source

The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]

, 2008
We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Andrew Evens, Joseph Buggy, Kevin David, Lauren Mauro, Leo Gordon, Mint Sirisawad, Richard Miller, Savita Bhalla, Sheila Prachand, Sriram Balasubramanian   +9 more
core   +1 more source

hydroxamic acids

, 2014
Citation: 'hydroxamic acids' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.H02911 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

A Comparative Study of C₂-Symmetric and C₁-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols

Molecules
Hydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments.
Marco Valtierra-Galván, Alfredo Rodríguez-Hernández, Israel Bonilla-Landa, Felipe Barrera-Méndez, Francisco Javier Enríquez-Medrano, Ramón Enrique Díaz de León-Gómez, José Luis Olivares-Romero   +6 more
doaj   +1 more source

Development and application of an assay for uranyl complexation by fungal metabolites, including siderophores [PDF]

, 2003
An assay to detect UO2 2+ complexation was developed based on the chrome azurol S (CAS) assay for siderophores (B. Schwyn and J. B. Neilands, Anal. Biochem.
Collison, David, Halliday, Verity, Livens, Francis R., Renshaw, Joanna C., Robson, Geoffrey D., Taylor, Robin J., Trinci, Anthony P J, Wiebe, Marilyn G.   +7 more
core   +2 more sources

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source