Results 81 to 90 of about 30,744 (233)

Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil

Molecules, 2011
Fatty hydroxamic acid derivatives were synthesized using Lipozyme TL IM catalyst at biphasic medium as the palm kernel oil was dissolved in hexane and hydroxylamine derivatives were dissolved in water: (1) N-methyl fatty hydroxamic acids (MFHAs); (2) N ...
Sidik Silong, Mazyar Peyda, Roshanak Rafiee-Moghaddam, Anuar Kassim, Yadollah Gharayebi, Nor Azah Yusof, Hossein Jahangirian, Md Jelas Haron   +7 more
doaj   +1 more source

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

Nature Communications, 2021
Current histone microarrays cannot be used to directly study the transient interactions of histone deacetylases (HDACs). Here, the authors show that hydroxamic acid-modified microarrays can capture HDACs, provide insights into their substrate specificity,
Carlos Moreno-Yruela, Michael Bæk, Adela-Eugenie Vrsanova, Clemens Schulte, Hans M. Maric, Christian A. Olsen   +5 more
doaj   +1 more source

Cobalt complexes with tripodal ligands: implications for the design of drug chaperones [PDF]

, 2012
Extensive research is currently being conducted into metal complexes that can selectively deliver cytotoxins to hypoxic regions in tumours. The development of pharmacologically suitable agents requires an understanding of appropriate ligand–metal systems
Bonnitcha, Paul D., Clegg, Jack K., Hambley, Trevor W., Hocking, Rosalie K., Kim, Byung J., Neville, Suzanne M., Turner, Peter   +6 more
core   +1 more source

Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine

ChemMedChem, Volume 21, Issue 1, January 2026.
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda, Dolores Aguilar‐Cázares, Angélica Flores–Flores, Miguel Ángel Santos‐Contreras, José S. López‐González, Rodrigo Aguayo‐Ortiz, Rogélio Hernández‐Pando, Francisco Hernández‐Luis   +7 more
wiley   +1 more source

Examining the PM6 semiempirical method for pKa prediction across a wide range of oxyacids [PDF]

, 2009
The pK~a~ estimation ability of the semiempirical PM6 method was evaluated across a broad range of oxyacids and compared to results obtained using the SPARC software program.
Kaya Forest, Ken J. Friesen, Sierra Rayne   +2 more
core   +1 more source

Synthesis of Non‐Isocyanate Poly(Sulfide Urethane) Adhesives by Thermally Initiated Thiol‐Ene Polymerization

Macromolecular Chemistry and Physics, Volume 227, Issue 2, 29 January 2026.
Three routes to poly(sulfide urethane)s were compared, identifying thermally initiated thiol‐ene polyaddition as very effective. Using α,ω‐diene‐functionalized carbamates and aliphatic dithiols under solvent‐free conditions with dicumyl peroxide as an initiator, high‐molar‐mass polyurethanes (Mn up to 19 kg mol−1) were obtained, with fewer byproducts ...
Nichollas G. Jaques, Audrey Llevot, Thomas Vidil, Étienne Grau, Olaf Hartman, Henri Cramail, Michael A. R. Meier   +6 more
wiley   +1 more source

Safety and preliminary efficacy of vorinostat with R-EPOCH in high-risk HIV-associated non-Hodgkin\u27s lymphoma (AMC-075) [PDF]

, 2018
We performed a phase I trial of vorinostat (VOR) given on days 1 to 5 with R-EPOCH (rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride) in patients with aggressive HIV-associated non-Hodgkin lymphoma.
Aboulafia, David, Ambinder, Richard F, Cesarman, Ethel, Henry, David, Lee, Jeanette Y, Mitsuyasu, Ronald, Moore, Page C, Noy, Ariela, Ramos, Juan C, Ratner, Lee, Reid, Erin G, Rudek, Michelle A, Sparano, Joseph A   +12 more
core   +2 more sources

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source

Chelation Therapy for Rare Earth Element Toxicity: Current Evidence, Challenges and Future Directions

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT The accelerating integration of rare earth elements (REEs) in advanced technologies has generated rising concern over human exposure and the attendant toxicological risks. This review presents an up‐to‐date synthesis of current evidence on REE toxicity across multiple exposure pathways, including inhalation, ingestion and occupational contact,
Jose L. Domingo
wiley   +1 more source

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors [PDF]

, 2014
Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents with a
Abdel-Magid A. F., Adams P. D., Afonine P. V., Alessandro Paiardini, Androulakis S., Babine R. E., Battye T. G., Biffis A., Bramucci E., Brunger A. T., Carroll R. K., CCP4., Changklungmoa N., Chiara Ruggeri, Chouhan G., Chowdhury N., Correa A., Cristau H. J., Deprez-Poulain R., Didier E. S., Dong L., Duffy S., Eswar N., Evans P., Evans P. R., Flipo M., Flipo M., Flipo M., Freedman L. D., Harbut M. B., Hitzerd S. M., Huang Q., Joseph P., Kabsch W., Kannan Sivaraman K., Klemba M., Komagal Kannan Sivaraman, Lee J., Lew V. L., Li F., Li L., Liguori A., Liu J., Marcin Drag, Massaro A., McGowan S., McGowan S., McGowan S., Meyer G. R., Mucha A., Nyssa Drinkwater, Oshovsky G. V., Peter J. Scammells, Poreba M., Riva E., Rosenthal P. J., Sabine Fletcher, Sang Q., Sasdekumar Loganathan, Schüttelkopf A. W., Shailesh N. Mistry, Sheena McGowan, Sivaraman K. K., Skinner-Adams T. S., Sreedhar B., Stack C. M., Swapna K., Taillefer M., Thomsen R., Tubaro C., Tufariello J. J., Uk Son S., Usachova N., Velmourougane G., Vicky M. Avery, Wadhwa K., Wickstrom M., Xu Z.-L., Zmitek J., Zou B.   +79 more
core   +4 more sources