Results 81 to 90 of about 30,527 (215)

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors [PDF]

, 2014
Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents with a
Abdel-Magid A. F., Adams P. D., Afonine P. V., Alessandro Paiardini, Androulakis S., Babine R. E., Battye T. G., Biffis A., Bramucci E., Brunger A. T., Carroll R. K., CCP4., Changklungmoa N., Chiara Ruggeri, Chouhan G., Chowdhury N., Correa A., Cristau H. J., Deprez-Poulain R., Didier E. S., Dong L., Duffy S., Eswar N., Evans P., Evans P. R., Flipo M., Flipo M., Flipo M., Freedman L. D., Harbut M. B., Hitzerd S. M., Huang Q., Joseph P., Kabsch W., Kannan Sivaraman K., Klemba M., Komagal Kannan Sivaraman, Lee J., Lew V. L., Li F., Li L., Liguori A., Liu J., Marcin Drag, Massaro A., McGowan S., McGowan S., McGowan S., Meyer G. R., Mucha A., Nyssa Drinkwater, Oshovsky G. V., Peter J. Scammells, Poreba M., Riva E., Rosenthal P. J., Sabine Fletcher, Sang Q., Sasdekumar Loganathan, Schüttelkopf A. W., Shailesh N. Mistry, Sheena McGowan, Sivaraman K. K., Skinner-Adams T. S., Sreedhar B., Stack C. M., Swapna K., Taillefer M., Thomsen R., Tubaro C., Tufariello J. J., Uk Son S., Usachova N., Velmourougane G., Vicky M. Avery, Wadhwa K., Wickstrom M., Xu Z.-L., Zmitek J., Zou B.   +79 more
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Multitarget Drugs: an Epigenetic Epiphany [PDF]

, 2016
Epigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes.
Atkinson, Baell, Baud, Beckers, Bentley, Blagodatski, Borretto, Bowman, Brand, Burg, Cai, Chen, Chen, Chen, Chen, Ciceri, Dancy, Deans, Fahy, Filippakopoulos, Finley, Fischer, Fuhrmann, Galloway, Gjertsen, Griffith, Guerrant, Guerrant, Hantschel, He, Huang, Hui, Hurley, Jing, Kaniskan, Kingston, Ko, Kortüm, Kozikowski, Lamblin, Lan, Ling, Liu, Lu, Lu, Maes, Mahboobi, Mahboobi, Mai, McGinty, McPherson, Micelli, Moore, Mottamal, Pachaiyappan, Pastor, Patel, Pereira, Pińa, Qian, Rask-Andersen, Rose, Rothbart, Rotili, Saijo, Saijo, Samatar, Schapira, Suganuma, Tavera-Mendoza, Villalba, Wagner, Winter, Wright, Yu, Yuan, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zuo, Álvarez   +84 more
core   +1 more source

Synthesis and Biological Evaluation of Novel Thiazolyl-Coumarin Derivatives as Potent Histone Deacetylase Inhibitors with Antifibrotic Activity

Molecules, 2019
New histone deacetylases (HDAC) inhibitors with low toxicity to non-cancerous cells, are a prevalent issue at present because these enzymes are actively involved in fibrotic diseases.
Viviana Pardo-Jiménez, Patricio Navarrete-Encina, Guillermo Díaz-Araya   +2 more
doaj   +1 more source

Development of Chemical Sensor Based on Fatty Hydroxamic Acid for The Determination of Vanadium (V) and Iron (Iii) Ions [PDF]

, 2005
Chemical sensor based on the use of uv-visible spectrophotometer and optical fibre reflectance spectrometer (OFRS) for the determination of Fe(II1) and V(V) ions have been developed in this study.
Isha, Azizul
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Removal of Hazardous Oxyanion Pollutants by Lanthanum (Iii) Hydroxide and Lanthanum (III) - Loaded Ion Exchangers [PDF]

, 2004
La(III) loaded poly(hydroxamic acid) chelating resin (LaPHA), lanthanum hydroxideloaded poly(hydroxamic acid) chelating resin (LaOHPHA) and lanthanum hydroxide (La(OH)3) were prepared and evaluated as sorbents for removal of As(V), As(III) and Cr(VI ...
Ahmed, Yehya M.
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In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole Linked with Hydroxamic Acid by Disulfide Bond and Certain Linkers with HDAC8 Enzyme

Al-Mustansiriyah Journal of Pharmaceutical Sciences
A new hybrid molecule of Benzothiazole cross-linked with hydroxamic acid through an amino acid or aminoalkanoic acid were synthesised. All the synthesized hybrid molecules (1-5) were subjected to molecular docking studies to evaluate their binding ...
Mayssam Hazem, Shakir M. Alwan
doaj   +1 more source

Cross metathesis-mediated synthesis of hydroxamic acid derivatives

Beilstein Journal of Organic Chemistry, 2018
An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N-benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs’ second generation catalyst within short time and in good
Shital Kumar Chattopadhyay, Subhankar Ghosh, Suman Sil   +2 more
doaj   +1 more source

Synthesis and Characterization of Poly(Hydroxamic Acid) and Poly(Amidoxime) Chelating Resins from Polymer Grafted Sago Starch [PDF]

, 1999
The graft copolymerization of methyl acrylate (MA) onto sago starch was performed by free radical initiating process in which ceric ammonium nitrate (CAN) was used as an initiator.
Rahman, Md. Lutfor
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Synthesis of elastomers for use with liquid fluorine Final report [PDF]

Synthesis and chemical properties of elastomeric polymers resistant to effects of fluorine, oxygen difluoride, nitrogen tetroxide, and similar ...
Brown, H. C., Mukherjee, A. R.
core   +1 more source

Khaya Cellulose Supported Copper Nanoparticles for Chemo Selective Aza-Michael Reactions [PDF]

, 2016
We prepared a highly active Khaya cellulose supported poly(hydroxamic acid) copper nanoparticles by the surface modification of Khaya cellulose through graft copolymerization and subsequently amidoximation.
Lutfor, M. R., M. M., Yusoff, Sarkar, Shaheen M.   +2 more
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