Results 171 to 180 of about 5,129,522 (237)

Protein domain movement involved in binding of belinostat and HPOB as inhibitors of histone deacetylase 6 (HDAC6): a hybrid automated-interactive docking study. [PDF]

J Comput Aided Mol Des
Iakovou G, Palmer L, Ganesan A, Kitao A, Laycock SD, Hayward S.   +5 more
europepmc   +1 more source

In vivo acute oral toxicity assessment of novel histone deacetylase 2 inhibitor. [PDF]

BMC Pharmacol Toxicol
Pai P, D'Mello RS, Nayak S, Rao P, Oruganti S, Satyamoorthy K, Sundara BK.   +6 more
europepmc   +1 more source

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Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters.

Chemistry, 2021
A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been ...
N. Nikitas, M. Apostolopoulou, Elpida Skolia, Anna Tsoukaki, C. Kokotos   +4 more
semanticscholar   +1 more source

Electrochemically Tuned Oxidative [4+2] Annulation and Dioxygenation of Olefins with Hydroxamic Acids.

Angewandte Chemie, 2020
This work represents the first [4+2] annulation of hydroxamic acids with olefins for the synthesis of benzo[c][1,2]oxazines scaffold via anode-selective electrochemical oxidation.
Bangyi Wei, Donghua Xie, Shengying Lai, Yu Jiang, Hong Fu, Dian Wei, B. Han   +6 more
semanticscholar   +1 more source

Hydroxamic Acids: A Unique Family of Chemicals with Multiple Biological Activities

, 2013

semanticscholar   +2 more sources

The Hydroxamic Acids as a Potential Anticancer and Neuroprotective Agents.

Current Medicinal Chemistry, 2020
Hydroxamic acids are a promising class of chemical compounds with proven antitumor potential, primarily due to its ability to inhibit the activity of histone deacetylase enzymes.
M. Neganova, S. Klochkov, Y. Aleksandrova, G. Aliev   +3 more
semanticscholar   +1 more source

Acidity of hydroxamic acids and amides

Organic & Biomolecular Chemistry, 2003
The relatively strong acidity of hydroxamic acids was analyzed by means of isodesmic reactions in which this acid or its anion is formed from simpler precursors. Acidity of amides was analyzed in the same way. Energies of all compounds involved in the reactions were calculated at the B3LYP/AUG-cc-pVTZ//B3LYP/6-311 + G(d,p) level; at this level a good ...
Stanislav, Böhm, Otto, Exner
openaire   +2 more sources

Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.

Journal of Medicinal Chemistry, 2018
We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6).
Chao-Wu Yu, Pei-Yun Hung, Hui Yang, Y. Ho, Hsing-Yi Lai, Yi-Sheng Cheng, J. Chern   +6 more
semanticscholar   +1 more source

Hydroxamic acid polymers

Journal of Polymer Science: Polymer Chemistry Edition, 1975
AbstractA polymer bearing hydroxamic acid groups and having a high affinity for iron(III) was prepared through the following procedure. Acryloylalanine (III), prepared by the reaction of acryloyl chloride with alanine, was treated with N‐hydroxysuccinimide in the presence of dicyclohexylcarbodiimide to give the N‐hydroxysuccinimide ester (IV).
Anthony Winston, Edward T. Mazza
openaire   +1 more source

Hydroxamic Acids as Pharmacological Agents

Current Medicinal Chemistry, 2002
A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as ...
Muri, Estela M.F., Nieto, Marcelo J., Sindelar, Robert D., Williamson, John S.   +3 more
openaire   +3 more sources