Definitions, 2020 A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the ...
semanticscholar +2 more sources
Hydroxamic acids in asymmetric synthesis. [PDF]
Acc Chem Res, 2013 Metal-catalyzed stereoselective reactions are a central theme in organic chemistry research. In these reactions, the stereoselection is achieved predominantly by introducing chiral ligands at the metal catalyst's center. For decades, researchers have sought better chiral ligands for asymmetric catalysis and have made great progress.
Li Z, Yamamoto H.
europepmc +5 more sources
A Comparative Study of C2-Symmetric and C1-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols [PDF]
MoleculesHydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments.
Marco Valtierra-Galván +6 more
doaj +2 more sources
Ecotoxicology and Environmental Safety, 2021 Currently there is a wide variety of collectors used in mineral processing, the xanthates being the most used in sulfides flotation. Unfortunately, it is known that xanthates are not stable compounds and their decomposition generates carbon disulfide ...
Martha Araceli Elizondo-Álvarez +2 more
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A general concept for the introduction of hydroxamic acids into polymers. [PDF]
Chem Sci, 2019 Polyethers (PEG) with hydroxamic acid groups enable chelation of a variety of metal ions, coating of metal oxide surfaces and stabilization of nanoparticles. In contrast to catechol, hydroxamic acids are oxidation stable and biocompatible.
Johann T, Keth J, Bros M, Frey H.
europepmc +2 more sources
Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure⁻Activity Relations of New Inhibitors of HDAC and/or Tubulin Function. [PDF]
Int J Mol Sci, 2019 New inhibitors of tubulin polymerization and/or histone deacetylase (HDAC) activity were synthesized by attaching alkyl tethered hydroxamic acid appendages of varying length to oxazole-bridged combretastatin A-4 analogous caps.
Schmitt F +8 more
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Facile Access to Fe(III)-Complexing Cyclic Hydroxamic Acids in a Three-Component Format [PDF]
Molecules, 2019 Cyclic hydroxamic acids can be viewed as effective binders of soluble iron and can therefore be useful moieties for employing in compounds to treat iron overload disease.
Evgeny Chupakhin +3 more
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Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor. [PDF]
Org Lett, 2016 A novel synthetic approach to amidoquinones by the reaction of naphthoquinones with hydroxamic acids under basic conditions was developed. The reaction is mild and operationally simple, and it affords high yields of amidoquinones. With this new method, a
Zhang C, Chou CJ.
europepmc +2 more sources
Utilization of Lead Nitrate to Enhance the Impact of Hydroxamic Acids on the Hydrophobic Aggregation and Flotation Behavior of Cassiterite [PDF]
MoleculesLead nitrate (LN) is frequently employed as an activator in the flotation of cassiterite using hydroxamic acids as the collectors. This study investigated the effect of LN on the hydrophobic aggregation of cassiterite when benzohydroxamic acid (BHA ...
Saizhen Jin +5 more
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Amide-forming chemical ligation via O-acyl hydroxamic acids. [PDF]
Proc Natl Acad Sci U S A, 2018 Dunkelmann DL +6 more
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