LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. [PDF]
Bioorg Med Chem Lett, 2016 Zur AA +13 more
europepmc +2 more sources
Glyoxalase-1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine. [PDF]
ChemMedChemA set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Martínez-Miranda J +7 more
europepmc +2 more sources
Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids. [PDF]
ACS Med Chem Lett, 2016 Borgström B +4 more
europepmc +2 more sources
Molbank, 2021 2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly
Dmitrii A. Aksenov +5 more
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SYNTHESIS AND IDENTIFICATION FOR SOME FERRIC COMPLEXES OF HYDROXAMIC ACID. [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2013 The aim of this research is to prepare and identification of the hydroxamic acid derivatives of diethyl succinate which are considered as selective ligands of the Iron (III) . The synthesis of hydroxamic acid derivatives was performed as described in the
ISMAEEL KH. AL-KATEEB +2 more
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Powdery mildew (Blumeria graminis f. sp. tritici) infection and amount of key defence chemicals - cyclic hydroxamic acids - of field cultivated wheat (Triticum aestivum L.) [PDF]
Journal of Central European Agriculture, 2020 Cultivated wheat varieties have different degrees of resistance against powdery mildew. Cyclic hydroxamic acids are key defence chemicals of wheat. Examinations comprised the measurement of cyclic hydroxamic acid content and powdery mildew infection of ...
Péter Makleit +2 more
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Organics, 2023 We describe a novel two-step approach for the synthesis of compounds with a hydroxyl-amide group (hydroxamic acids), which are widely known for their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others ...
Bogdan A. Tretyakov +2 more
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PREPARATION OF NEW COMPLEXES DERIVED FROM DIETHYLGLUTART AND STUDYING THEIR SPECTRUM PROPERTIES AND BIOLOGICAL ACTIVITY [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2012 This research designed to be on four steps: The first step includes preparation of a group legends derived from glutaric acid, the second step which the research includes is converting the acid derivatives that being prepared into hydroxamic acids.
SHAKIR F TULEAB
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A review on Hydroxamic Acids: Widespectrum Chemotherapeutic Agents
International Journal of Biology and Biomedical Engineering, 2020 Recent developments in drug discovery have highlighted the ability of hydroxamic acids to form complexes with various metal ions, in particular iron, zinc, magnesium and calcium, and this imparts them with a number of unique biological and ...
semanticscholar +1 more source
SYNTHESIS AND IDENTIFICATION OF SOME HYDROXAMIC DERIVATIVES AND STUDYING THEIR THERMO AND PHOTO DEGRADATION [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2014 The aim of this research is to prepare and study the kinetics effect of temperature and photochemical reactions of the hydroxamic acid derivatives of diethyl succinate through the interaction of alkyl halides and diethyl succinate in the presence of ...
ISMAIL AL-KHATEEB +2 more
doaj +1 more source