Results 61 to 70 of about 5,129,522 (237)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum

Molecules, 2016
Many cereals accumulate hydroxamic acids involved in defense of plant against various fungi, bacteria, and insects. 2,4-dihydroxy-7-methoxy-1,4-benzoxazine-3-one, commonly known as DIMBOA, is one of the principal cyclic hydroxamic acids in aqueous ...
Bing Guo, Yongqiang Zhang, Shili Li, Ting Lai, Liang Yang, Juanni Chen, Wei Ding   +6 more
doaj   +1 more source

Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis

Pharmaceuticals, 2022
Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide and for which the control strategy consists of mass treatment with the only available drug, praziquantel.
Ehab Ghazy, Mohamed Abdelsalam, Dina Robaa, Raymond J. Pierce, Wolfgang Sippl   +4 more
doaj   +1 more source

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, Volume 46, Issue 3, Page 950-960, March 2026.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

Antimicrobial Activity of Hydroxamic Acids

Chemical and Pharmaceutical Bulletin, 1971
o-, m- and p-alkyloxybenzohydroxamic acids were synthesized and subjected to the examination for antibacterial and antifungal activity. All the hydroxamic acids tested were almost ineffective for pathogens examined of Enterobacteriaceae, but some of alkyloxybenzo- and fatty acyl-hydroxamic acid were found to be as highly effective for pathogenic fungi ...
J, Hase, K, Kobashi, N, Kawaguchi, K, Sakamoto   +3 more
openaire   +3 more sources

Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC

Molecules, 2020
With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention.
Jiangying Cao, Wei Zhao, Chunlong Zhao, Qian Liu, Shunda Li, Guozhen Zhang, C. James Chou, Yingjie Zhang   +7 more
doaj   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Maize rhm1 Resistance to Bipolaris maydis Is Associated with Few Differences in Pathogenesis-Related Proteins and Global mRNA Profiles

Molecular Plant-Microbe Interactions, 2001
The maize rhm1 mutant resists Bipolaris maydis, the causal agent of Southern corn leaf blight, by producing small necrotic lesions surrounded by chlorotic haloes.
Carl R. Simmons, Susan Grant, Daniel J. Altier, Patrick F. Dowd, Oswald Crasta, Otto Folkerts, Nasser Yalpani   +6 more
doaj   +1 more source

Effect of magnetic MMP removal on long‐term dentin collagen stability

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract Several matrix metalloproteinase (MMP) inhibitors have been investigated for their ability to improve dentin‐bond longevity. However, MMPs tend to reactivate over time, especially using simplified etch‐and‐rinse adhesives. This study investigated a novel magnetic removal of dentinal MMPs on bonding durability, MMP inhibition and collagen ...
Walter Zenobi, Salvatore Sauro, Davino Machado Andrade Neto, Karen Evellin Moura Cordeiro, Francisco Avelino, Diego Lomonaco, Pierre Basilio Almeida Fechine, Yu Fu Chou, Garrit Koller, Thiago Soares Porto, Victor Pinheiro Feitosa   +10 more
wiley   +1 more source