Results 81 to 90 of about 21,287 (222)

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC

Molecules, 2020
With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention.
Jiangying Cao, Wei Zhao, Chunlong Zhao, Qian Liu, Shunda Li, Guozhen Zhang, C. James Chou, Yingjie Zhang   +7 more
doaj   +1 more source

Speciation and Mobilization of Toxic Heavy Metal Ions by Methanogenic Bacteria [PDF]

, 1993
HWRIC Project HWR 92 ...
Conver, Shawn, Dayton, Tressia M., Foster, Mark S., Koropchak, John A., Niederhoffer, Eric C., Rodabough, Allyson   +5 more
core  

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors [PDF]

, 2014
Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents with a
Abdel-Magid A. F., Adams P. D., Afonine P. V., Alessandro Paiardini, Androulakis S., Babine R. E., Battye T. G., Biffis A., Bramucci E., Brunger A. T., Carroll R. K., CCP4., Changklungmoa N., Chiara Ruggeri, Chouhan G., Chowdhury N., Correa A., Cristau H. J., Deprez-Poulain R., Didier E. S., Dong L., Duffy S., Eswar N., Evans P., Evans P. R., Flipo M., Flipo M., Flipo M., Freedman L. D., Harbut M. B., Hitzerd S. M., Huang Q., Joseph P., Kabsch W., Kannan Sivaraman K., Klemba M., Komagal Kannan Sivaraman, Lee J., Lew V. L., Li F., Li L., Liguori A., Liu J., Marcin Drag, Massaro A., McGowan S., McGowan S., McGowan S., Meyer G. R., Mucha A., Nyssa Drinkwater, Oshovsky G. V., Peter J. Scammells, Poreba M., Riva E., Rosenthal P. J., Sabine Fletcher, Sang Q., Sasdekumar Loganathan, Schüttelkopf A. W., Shailesh N. Mistry, Sheena McGowan, Sivaraman K. K., Skinner-Adams T. S., Sreedhar B., Stack C. M., Swapna K., Taillefer M., Thomsen R., Tubaro C., Tufariello J. J., Uk Son S., Usachova N., Velmourougane G., Vicky M. Avery, Wadhwa K., Wickstrom M., Xu Z.-L., Zmitek J., Zou B.   +79 more
core   +4 more sources

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

A Simple Method for the Isolation and Purification of 2,4-Dihydroxy-7-Methoxy-2H-1,4-Benzoxazin-3(4H)-One (DIMBOA) from Maize (Zea mays L.) Seedlings

Journal of Integrative Agriculture, 2013
2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA), the dominant benzoxazinoid hydroxamic acid in maize (Zea Mays L.), serves as important factors of resistance against insects and microbial diseases, allelochemicals used in competition with ...
Jing LI, Xin-gang LIU, Feng-shou DONG, Jun XU, Li-qun GUO, Zhi-qiang KONG, Ying-ying TIAN, Yan-bin WU, Yong-quan ZHENG   +8 more
doaj   +1 more source

Synthesis Optimization of L-Aspartic acid β-hydroxamate by a novel Enzyme, β-Aspartyl-γ-glutamyl transferase [PDF]

, 2015
L-Aspartic acid β-hydroxamate or L-β-Aspartyl hydroxamate (BAH), water soluble- chemical compound currently obtains popularity due to its role in several important biochemical processes and to its bioactivities.
Naohara, Ryosuke, Nonomura, Yuki, Prihanto, Asep Awaludin, Takagi, Kazuyoshi, Wakayama, Mamoru   +4 more
core  

The use of nano/micro-layers, self-healing and slow release coatings to prevent corrosion and biofouling [PDF]

, 2014
The mitigation of corrosion and biofouling is a challenge. Through application of chemicals and special techniques can slow these undesired processes, an effective resolution requires a multidisciplinary approach involving scientists, engineers, and ...
Ai, Alagta, Aldcroft, Andrews, Aramaki, Aramaki, Avis, Baier, Baum, Bergsson, Berkeley, Beyenal, Blodgett, Blodgett, Borenstein, Borisova, Boura, Cassie, Choi, Collazo, Crundwell, Córdoba-Torres, Dafforn, Dai, Deflorian, Deng, Desimone, Dias, Edge, Fedrizzi, Feng, Gaines, García, Garrett, Ghareba, Ghosh, Ghosh, Gold, Grigoriev, Grundmeier, Guarda, Hao, Hart, He, Hong, Hoque, Hoque, Hutt, Ishibashi, Javaherdashti, Javaherdashti, Jennings, Jones, Kaesche, Kear, Kearns, Keller, Kelly, Keszthelyi, Kumar, Kuznetsov, Laibinis, Lambert, Langmuir, Lee, Lewandowski, Li, Little, Liu, Lorenz, Lusk, Ma, Mahapatro, Malayoglu, Mansfeld, Marcus, Marcus, Marcus, Mauldin, McCafferty, McIlroy, Mekhalif, Metikoš-Huković, Miale, Mihm, Mok, Montemor, Motornov, Murphy, Nesterova, Nesterova, Neumann, Nordstierna, Nuzzo, Pilbáth, Podszun, Raman, Raman, Reybuck, Rigó, Rocca, Románszki, Románszki, Románszki, Románszki, Románszki, Románszki, Rong, Ruan, Sahoo, Samadzadeh, Samadzadeh, Sanchez, Sanchez-Amaya, Scully, Selvakumar, Shchukin, Sherar, Shin, Sinapi, Skrivanova, Sonawane, Song, Stack, Su, Sun, Sun, Szabó, Sørensen, Tan, Tan, Tao, Telegdi, Telegdi, Telegdi, Telegdi, Telegdi, Telegdi, Telegdi, Telegdi, Thomas, Tong, Tremont, Tremont, Tsutsumi, Valentinelli, Videla, Wallström, Walton, Wang, Wang, Wang, Wang, Wenzel, Whelan, White, Wilhelmy, Wu, Yamamoto, Yang, Yang, Young, Yuan, Yuan, Zhang, Zhang, Zhang, Zhang, Zhao, Zheludkevich, Zheludkevich, Zheludkevich, Zisman   +172 more
core   +1 more source

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long, Franz‐Josef Meyer‐Almes, Aleksandra Kopranovic, Stephen P. Wren   +3 more
wiley   +1 more source

Fdb1 and Fdb2, Fusarium verticillioides Loci Necessary for Detoxification of Preformed Antimicrobials from Corn

Molecular Plant-Microbe Interactions, 2002
Fusarium verticillioides is a fungus of significant economic importance because of its deleterious effects on plant and animal health and on the quality of their products. Corn (Zea mays) is the primary host for F.
A. E. Glenn, S. E. Gold, C. W. Bacon
doaj   +1 more source