Results 81 to 90 of about 21,152 (225)

Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

Molecules, 2020
Coumarin-hydroxamic acid derivatives 7a–k were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were synthesized in moderate yields (30–87%) through a simple methodology, biological evaluation was ...
Santiago García, Itzel Mercado-Sánchez, Luis Bahena, Yolanda Alcaraz, Marco A. García-Revilla, Juvencio Robles, Nancy Santos-Martínez, David Ordaz-Rosado, Rocío García-Becerra, Miguel A. Vazquez   +9 more
doaj   +1 more source

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors [PDF]

, 2014
Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents with a
Abdel-Magid A. F., Adams P. D., Afonine P. V., Alessandro Paiardini, Androulakis S., Babine R. E., Battye T. G., Biffis A., Bramucci E., Brunger A. T., Carroll R. K., CCP4., Changklungmoa N., Chiara Ruggeri, Chouhan G., Chowdhury N., Correa A., Cristau H. J., Deprez-Poulain R., Didier E. S., Dong L., Duffy S., Eswar N., Evans P., Evans P. R., Flipo M., Flipo M., Flipo M., Freedman L. D., Harbut M. B., Hitzerd S. M., Huang Q., Joseph P., Kabsch W., Kannan Sivaraman K., Klemba M., Komagal Kannan Sivaraman, Lee J., Lew V. L., Li F., Li L., Liguori A., Liu J., Marcin Drag, Massaro A., McGowan S., McGowan S., McGowan S., Meyer G. R., Mucha A., Nyssa Drinkwater, Oshovsky G. V., Peter J. Scammells, Poreba M., Riva E., Rosenthal P. J., Sabine Fletcher, Sang Q., Sasdekumar Loganathan, Schüttelkopf A. W., Shailesh N. Mistry, Sheena McGowan, Sivaraman K. K., Skinner-Adams T. S., Sreedhar B., Stack C. M., Swapna K., Taillefer M., Thomsen R., Tubaro C., Tufariello J. J., Uk Son S., Usachova N., Velmourougane G., Vicky M. Avery, Wadhwa K., Wickstrom M., Xu Z.-L., Zmitek J., Zou B.   +79 more
core   +4 more sources

A Systematic Review on the Contribution of Epigenetics to Noise‐Induced Hearing Loss

Sensory Neuroscience, Volume 2, Issue 1, March 2026.
ABSTRACT Noise‐induced hearing loss (NIHL) is a prevalent sensorineural impairment with significant inter‐individual variability in susceptibility, suggesting epigenetic factors play crucial roles in disease pathogenesis. This systematic review aimed to synthesize evidence on epigenetic mechanisms in NIHL and evaluate their biomarker potential ...
Jing Liu, Xiaotong Huang, Weijiang Liao, Junzhi Wu, Weiwei He, Wen Yang, Lin Cheng, Junlan Chuan, Jiangang Fan, Xinghua Tang   +9 more
wiley   +1 more source

Preparation and Characterization of Pectin Hydroxamates from Citrus Unshiu Peels [PDF]

Journal of Excipients and Food Chemicals
Pectin was extracted from unshiu orange (Citrus unshiu) peels and was subjected to chemical modification using hydroxamic acid. The structural and physical properties of the resulting derivatives were investigated as a function of hydroxamic acid content
In Young Bae, Hyun Jae Rha, Suyong Lee, Hyeon Gyu Lee   +3 more
doaj  

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, Volume 36, Issue 17, 26 February 2026.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

A Simple Method for the Isolation and Purification of 2,4-Dihydroxy-7-Methoxy-2H-1,4-Benzoxazin-3(4H)-One (DIMBOA) from Maize (Zea mays L.) Seedlings

Journal of Integrative Agriculture, 2013
2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA), the dominant benzoxazinoid hydroxamic acid in maize (Zea Mays L.), serves as important factors of resistance against insects and microbial diseases, allelochemicals used in competition with ...
Jing LI, Xin-gang LIU, Feng-shou DONG, Jun XU, Li-qun GUO, Zhi-qiang KONG, Ying-ying TIAN, Yan-bin WU, Yong-quan ZHENG   +8 more
doaj   +1 more source

Speciation and Mobilization of Toxic Heavy Metal Ions by Methanogenic Bacteria [PDF]

, 1993
HWRIC Project HWR 92 ...
Conver, Shawn, Dayton, Tressia M., Foster, Mark S., Koropchak, John A., Niederhoffer, Eric C., Rodabough, Allyson   +5 more
core  

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +2 more sources

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Fdb1 and Fdb2, Fusarium verticillioides Loci Necessary for Detoxification of Preformed Antimicrobials from Corn

Molecular Plant-Microbe Interactions, 2002
Fusarium verticillioides is a fungus of significant economic importance because of its deleterious effects on plant and animal health and on the quality of their products. Corn (Zea mays) is the primary host for F.
A. E. Glenn, S. E. Gold, C. W. Bacon
doaj   +1 more source