Results 81 to 90 of about 5,129,522 (237)
Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways
MedComm, Volume 7, Issue 1, January 2026.Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho +18 more
wiley +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.ABSTRACT The accelerating integration of rare earth elements (REEs) in advanced technologies has generated rising concern over human exposure and the attendant toxicological risks. This review presents an up‐to‐date synthesis of current evidence on REE toxicity across multiple exposure pathways, including inhalation, ingestion and occupational contact,
Jose L. Domingo
wiley +1 more source
Matrix Metalloproteinase Inhibition in Melanoma
Experimental Dermatology, Volume 35, Issue 1, January 2026.ABSTRACT Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix (ECM) and are found to participate in all stages of tumour progression including modifying signalling pathways, regulating cytokines and promoting tumour growth, particularly by inducing angiogenesis and facilitating cancer spread.
Ellie Zhang +2 more
wiley +1 more source
Rational Design of Novel Inhibitors: Integrating 3D‐QSAR and Molecular Dynamics
BioMed Research International, Volume 2026, Issue 1, 2026.This study presents an integrated computational framework that combines three‐dimensional quantitative structure–activity relationship (3D‐QSAR) modeling with molecular dynamics (MD) simulations to advance the rational design of triazole‐based urease inhibitors.
Neda Shakour +4 more
wiley +1 more source
Pharmacological Effects of Anthranilic Hydroxamic Acid and Certain Other Hydroxamic Acids
Experimental Biology and Medicine, 1960 SummaryThe hydroxamate of anthranilic acid injected intraperitoneally into rats in a dose of 1.0 mg/g causes anesthesia lasting 10 hours or more. Recovery is apparently complete. One half this dose causes tranquilization and suppression of the conditioned avoidance response. The compound protects mice against twice the lethal dose of strychnine.
F. Bernheim, J. K. Stoops
openaire +1 more source
Scientific ReportsHydroxamic acids represent a group of weak organic acids, both naturally occurring and synthetically derived, characterized by the general formula RC(= O)N(R’OH).
Rubi Khilari +8 more
doaj +1 more source
Crystal structure of N-hydroxypicolinamide monohydrate
Acta Crystallographica Section E: Crystallographic Communications, 2016 The crystal structure of the title compound, C6H6N2O2·H2O, consists of N-hydroxypicolinamide and water molecules connected through O—H...O and N—H...N hydrogen bonds.
Inna S. Safyanova +2 more
doaj +1 more source
Design, Synthesis and Biological Evaluation of Novel (Quinolinyl-3-pyridinyl)benzenesulfonamide-Based Hydroxamic Acids as PI3K and HDAC Dual Targeting Inhibitors [PDF]
, 2020 Yiyu Gu +6 more
openalex +1 more source
The Analytical Applications And Biological Activity of Hydroxamic acids
, 2014 Hydroxamic acids play a vital role in applied chemistry , the present literature review is an investigation on the analytical applications and biological activity of hydroxamic acids .
M. Abualreish +1 more
semanticscholar +1 more source