Results 261 to 270 of about 13,017 (296)
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Brain and Development, 1994
The clinical findings in six patients from three families with 4-hydroxybutyric aciduria are described. The onset of disease was in early infancy in all cases. All infants presented with severe global delay and severe hypotonia, and all patients had seizure disorder.
Z, Rahbeeni +9 more
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The clinical findings in six patients from three families with 4-hydroxybutyric aciduria are described. The onset of disease was in early infancy in all cases. All infants presented with severe global delay and severe hypotonia, and all patients had seizure disorder.
Z, Rahbeeni +9 more
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Applied Microbiology and Biotechnology, 2009
4-Hydroxybutyrate (4HB) was produced by Aeromonas hydrophila 4AK4, Escherichia coli S17-1, or Pseudomonas putida KT2442 harboring 1,3-propanediol dehydrogenase gene dhaT and aldehyde dehydrogenase gene aldD from P. putida KT2442 which are capable of transforming 1,4-butanediol (1,4-BD) to 4HB.
Lei, Zhang +3 more
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4-Hydroxybutyrate (4HB) was produced by Aeromonas hydrophila 4AK4, Escherichia coli S17-1, or Pseudomonas putida KT2442 harboring 1,3-propanediol dehydrogenase gene dhaT and aldehyde dehydrogenase gene aldD from P. putida KT2442 which are capable of transforming 1,4-butanediol (1,4-BD) to 4HB.
Lei, Zhang +3 more
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Ecofriendly poly(3-hydroxybutyrate-co-4-hydroxybutyrate) microbeads for sanitary products
International Journal of Biological Macromolecules, 2023In the past, plastic microbeads (MBs) were added to personal healthcare products to improve the cleaning and exfoliating effects, but these have been withdrawn owing to their non-degradable nature and contribution to the pollution of marine environment, especially that caused by the adsorption of persistent organic pollutants (POPs) on MBs.
Yun Hyeok, Choi +5 more
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International Journal of Neuropharmacology, 1964
Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
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Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
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BioEssays, 1984
AbstractRecent work has led to the discovery of six patients with 4‐hydroxybutyric acid‐uria, a severe hereditary human pathology characterized by the accumulation of a compound of known neuropharmacologic activity in body fluids. The enzymatic deficiency has been localized to succinic semialdehyde dehydrogenase, one of two enzymes involved in the ...
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AbstractRecent work has led to the discovery of six patients with 4‐hydroxybutyric acid‐uria, a severe hereditary human pathology characterized by the accumulation of a compound of known neuropharmacologic activity in body fluids. The enzymatic deficiency has been localized to succinic semialdehyde dehydrogenase, one of two enzymes involved in the ...
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Gamma-hydroxybutyrate withdrawal syndrome
Annals of Emergency Medicine, 2001Gamma-hydroxybutyrate (GHB) withdrawal syndrome is increasingly encountered in emergency departments among patients presenting for health care after discontinuing frequent GHB use. This report describes the characteristics, course, and symptoms of this syndrome.A retrospective review of poison center records identified 7 consecutive cases in which ...
J E, Dyer, B, Roth, B A, Hyma
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Pediatric Gamma Hydroxybutyrate Intoxication
Academic Emergency Medicine, 1997ABSTRACTReported are 2 uncommon cases of childhood gamma hydroxybutyrate (GHB) toxicity and the surreptitious manner in which GHB was made. Two children unintentionally ingested a soft drink containing GHB and were found comatose. Both had been well 1 hour earlier.
S, Suner, C S, Szlatenyi, R Y, Wang
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2009
Abstract Properties of Special Interest Biocompatibility and biodegradability. Biologically produced PHB is a semicrystalline isotactic stereoregular polymer of 100% R configuration that allows a high level of degradability. PHB is obtained by fermentation of bacteria capable of biosynthesizing polyesters as energy storage media.
Isao Noda +2 more
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Abstract Properties of Special Interest Biocompatibility and biodegradability. Biologically produced PHB is a semicrystalline isotactic stereoregular polymer of 100% R configuration that allows a high level of degradability. PHB is obtained by fermentation of bacteria capable of biosynthesizing polyesters as energy storage media.
Isao Noda +2 more
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A potential new metabolite of gamma-hydroxybutyrate: sulfonated gamma-hydroxybutyric acid
International Journal of Legal Medicine, 2015Detection of gamma-hydroxybutyric acid (GHB) became crucial in many clinical and forensic settings due to its increasing use for recreational purposes and drug-facilitated sexual assault. Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently identified GHB-glucuronide exhibits a
Stephanie, Hanisch +2 more
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Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) formation fromγ-aminobutyrate and glutamate
Biotechnology and Bioengineering, 2000To provide 4-hydroxybutyryl-CoA for poly(3-hydroxybutyrate-co-4-hydroxybutyrate) formation from glutamate in Escherichia coli, an acetyl-CoA:4-hydroxybutyrate CoA transferase from Clostridium kluyveri, a 4-hydroxybutyrate dehydrogenase from Ralstonia eutropha, a gamma-aminobutyrate:2-ketoglutarate transaminase from Escherichia coli, and glutamate ...
H E, Valentin, S, Reiser, K J, Gruys
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