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Hydroxychloroquine and Cardiotoxicity
Cardiology in Review, 2023Hydroxychloroquine (HCQ) has been used for rheumatological diseases such as systemic lupus erythematous and rheumatoid arthritis and demonstrated to improve clinical symptoms and reduce long-term sequelae. The drug is metabolized in the liver, is primarily excreted through the kidney, and works by modulating major histocompatibility complex (MHC) and ...
Subo, Dey +6 more
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Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19
Annals of Internal Medicine, 2021TO THE EDITOR: Brailovski and colleagues (1) attributed their patient's rosuvastatin-induced myotoxicity to a possible rosuvastatin–canagliflozin interaction. The assumed interaction was based on known and speculated factors.
Claudia N. Paiva, D. Tausk
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Hydroxychloroquine and the Retina
JAMA, 2015Hydroxychloroquine sulfate is widely prescribed in the treatment of systemic lupuserythematosus (SLE), rheumatoidarthritis, and related autoimmunediseases, and it has largely superseded the use of chloroquinephosphate for these conditions. Furthermore, hydroxychloroquine isnowbeingevaluated forothermedical uses, including controlofbloodglucose ...
Michael F. Marmor, Ronald B. Melles
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[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2020OBJECTIVE To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19).
Jun Chen +13 more
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Hydroxychloroquine Dose and Risk for Incident Retinopathy
Annals of Internal Medicine, 2023BACKGROUND Hydroxychloroquine is recommended for all patients with systemic lupus erythematosus and is often used for other inflammatory conditions, but a critical long-term adverse effect is vision-threatening retinopathy.
R. Melles +8 more
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Hydroxychloroquine Retinopathy
American Journal of Ophthalmology, 1991We analyzed ocular findings from two patients (aged 49 and 60 years) with hydroxychloroquine (Plaquenil, Winthrop Pharmaceuticals, Division of Sterling Drug, Inc., New York, New York) retinopathy. Both patients were treated for systemic lupus erythematosus; one patient was treated with 400 to 800 mg of hydroxychloroquine per day (6.1 to 12.2 mg/kg of ...
A, Weiner +4 more
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Archives of Ophthalmology, 1982
To the Editor. —The article by Tobin et al published in the JanuaryArchives(1982;100:81-83) on the safety of hydroxychloroquine sulfate recalls my experience with this drug in rheumatic diseases. During the past 15 years, I have followed up approximately 100 patients with rheumatoid arthritis and lupus erythematosus who were given hydroxychloroquine ...
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To the Editor. —The article by Tobin et al published in the JanuaryArchives(1982;100:81-83) on the safety of hydroxychloroquine sulfate recalls my experience with this drug in rheumatic diseases. During the past 15 years, I have followed up approximately 100 patients with rheumatoid arthritis and lupus erythematosus who were given hydroxychloroquine ...
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Massive hydroxychloroquine overdose
Acta Anaesthesiologica Scandinavica, 2004We report a case presenting with massive overdose of hydroxychloroquine who survived without any sequelae. A 17‐year‐old girl presented to the Emergency Department 45 min after the ingestion of 22 g of hydroxychloroquine in a suicide attempt. We believe this is highest dose yet reported in the medical literature. The patient developed hypotension, life‐
Demir, OF +3 more
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Treatment of hydroxychloroquine overdose
The American Journal of Emergency Medicine, 2001Hydroxychloroquine overdoses are rarely reported with 7 previous cases found in the English medical literature. We report a case and review the literature. A 16-year-old girl ingested a handful of hydroxychloroquine 200mg, 30 minutes before presentation and presented with tachycardia (heart rate 110 beats/min), hypotension (systolic blood pressure 63 ...
Kathy Marquardt, Timothy E Albertson
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Hydroxychloroquine-Induced Agranulocytosis
Archives of Dermatology, 1968A case of hydroxychloroquine-induced agranulocytosis in a patient with discoid lupus erythematosus is reported. The patient had previously received chloroquine therapy for several months. Leukopenia preceded the appearance of agranulocytosis, and persisted for six weeks following clinical recovery.
K S Taylor, D Chernof
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