Results 211 to 220 of about 5,905,176 (286)
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Drug metabolism reviews (Softcover ed.), 2023
The phenomenon of chirality has been shown to greatly impact drug activities and effects. Different enantiomers may exhibit different effects in a certain biological condition or disease state.
Sara A. Helal +2 more
semanticscholar +1 more source
The phenomenon of chirality has been shown to greatly impact drug activities and effects. Different enantiomers may exhibit different effects in a certain biological condition or disease state.
Sara A. Helal +2 more
semanticscholar +1 more source
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2020
Platelet 12-lipoxygenase(p-12-LOX) is highly expressed in human platelets, and the development of p-12-LOX inhibitors have the potential to be a novel antithrombotic tool by inhibiting thrombosis without prolonging hemostasis.
S. Tacconelli +9 more
semanticscholar +1 more source
Platelet 12-lipoxygenase(p-12-LOX) is highly expressed in human platelets, and the development of p-12-LOX inhibitors have the potential to be a novel antithrombotic tool by inhibiting thrombosis without prolonging hemostasis.
S. Tacconelli +9 more
semanticscholar +1 more source
Chemico-Biological Interactions, 2019
Cytochrome P450 (P450) enzymes are superfamily of monooxygenases that hold the utmost diversity of substrate structures and catalytic reaction forms amongst all other enzymes.
S. Shoieb +2 more
semanticscholar +1 more source
Cytochrome P450 (P450) enzymes are superfamily of monooxygenases that hold the utmost diversity of substrate structures and catalytic reaction forms amongst all other enzymes.
S. Shoieb +2 more
semanticscholar +1 more source
Brain Microvessels Produce 12‐Hydroxyeicosatetraenoic Acid
Journal of Neurochemistry, 1989Abstract: Cerebral microvessels isolated from perfused, adult murine brain produce a compound with the chromatographic properties of a monohydroxyeicosatetraenoic acid when incubated with arachidonic acid or stimulated with calcium ionophore A23187. The formation of this arachidonic acid metabolite is not reduced in the presence of the cyclooxy‐genase ...
S A, Moore +3 more
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5-Hydroxyeicosatetraenoic acid and human parturition
Prostaglandins, 19965-Hydroxyeicosatetraenoic acid (5-HETE) is an arachidonic acid (AA) metabolite derived from the lipoxygenase pathway which is capable of inducing uterine contractions. The purpose of this study was to determine a). whether 5-HETE concentrations in amniotic fluid increase before or after the onset of labor and b).
Edwin, S. S. +4 more
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Biochemical and Biophysical Research Communications, 1980
Abstract Highly purified rat mast cells converted 1.12% and 1.64% of exogenously added [1- 14 C]arachidonic acid to 5-OH-6,8,11,14 eicosatetraenoic acid (5-HETE) and 12-OH-5,8,10,14 eicosatetraenoic acid (12-HETE) respectively during a three minute incubation at 37°.
W F, Stenson, C W, Parker, T J, Sullivan
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Abstract Highly purified rat mast cells converted 1.12% and 1.64% of exogenously added [1- 14 C]arachidonic acid to 5-OH-6,8,11,14 eicosatetraenoic acid (5-HETE) and 12-OH-5,8,10,14 eicosatetraenoic acid (12-HETE) respectively during a three minute incubation at 37°.
W F, Stenson, C W, Parker, T J, Sullivan
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20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure
Current Opinion in Nephrology and Hypertension, 2001The properties of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids, vasoactivity and modulation of ion transport and mediation/modulation of the effects of vasoactive hormones, such as angiotensin II and endothelin, underscore their importance to renal vascular mechanisms and electrolyte excretion.
J C, McGiff, J, Quilley
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985
Human umbilical arteries convert arachidonic acid into three hydroxy-eicosatetraenoic acids as well as 6-ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and D2 and thromboxane B2. Two of these hydroxy derivatives of arachidonic acid were purified by reverse-phase HPLC and identified by GC-MS as 11-hydroxyeicosatetraenoic acid (11-HETE) and 15 ...
B N, Setty, M J, Stuart, R W, Walenga
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Human umbilical arteries convert arachidonic acid into three hydroxy-eicosatetraenoic acids as well as 6-ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and D2 and thromboxane B2. Two of these hydroxy derivatives of arachidonic acid were purified by reverse-phase HPLC and identified by GC-MS as 11-hydroxyeicosatetraenoic acid (11-HETE) and 15 ...
B N, Setty, M J, Stuart, R W, Walenga
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Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension
Current Opinion in Nephrology and Hypertension, 2004Cytochrome P-450 metabolites of arachidonic acid have been reported to play an important role in the control of renal function and vascular tone, and in the long-term control of arterial pressure. In this regard, 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor that inhibits sodium reabsorption in the kidney.
Albert, Sarkis +2 more
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Promotion of adipogenesis by 15-(S)-hydroxyeicosatetraenoic acid
Prostaglandins & Other Lipid Mediators, 2016Excess adipogenesis is a characteristic of obesity, which is associated with serious health problem, including type 2 diabetes. Here, to better understand the mechanisms for the development of adipocytes, we investigated the regulatory role of 15-(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in adipogenesis by treating 3T3-L1 murine preadipocytes and ...
Yong-Seok, Song +5 more
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