Results 221 to 230 of about 5,905,176 (286)

Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase

American Journal of Physiology-Renal Physiology, 2003
20-HETE, a potent vasoconstrictor, is generated by cytochrome P-450 ω-hydroxylases and is the principal eicosanoid produced by preglomerular microvessels. It is released from preglomerular microvessels by ANG II and is subject to metabolism by cyclooxygenase (COX).
Monica K, Cheng, John C, McGiff, Mairead A, Carroll   +2 more
openaire   +2 more sources

Inhibitors of 20-Hydroxyeicosatetraenoic Acid Reduce Renal Vasoconstrictor Responsiveness

The Journal of Pharmacology and Experimental Therapeutics, 2003
20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived constrictor eicosanoid produced by the preglomerular vasculature where it contributes to regulation of tone. Removal of the tonic inhibitory influence of nitric oxide (NO) has been reported to increase renal 20-HETE release.
J, Quilley, Y, Qiu, J, Hirt
openaire   +2 more sources

20-Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling

American Journal of Physiology-Heart and Circulatory Physiology, 2008
Nitric oxide (NO), generated from l-arginine by endothelial nitric oxide synthase (eNOS), is a key endothelial-derived factor whose bioavailability is essential to the normal function of the endothelium. Endothelium dysfunction is characterized by loss of NO bioavailability because of either reduced formation or accelerated degradation of NO.
Jennifer, Cheng, Jing-Song, Ou, Harpreet, Singh, John R, Falck, Dubasi, Narsimhaswamy, Kirkwood A, Pritchard, Michal Laniado, Schwartzman   +6 more
openaire   +2 more sources

Mass spectrometry of underivatized 15-hydroxyeicosatetraenoic acid and 15-hydroxyeicosapentaenoic acid

Biological Mass Spectrometry, 1988
A direct mass spectrometric method for 15-hydroxy metabolites of arachidonic acid and of eicosapentaenoic acid is described. 15-Hydroxyeicosanoids have the capacity to inhibit the formation of leukotrienes, potent mediators of inflammation formed by the 5-lipoxygenase pathway of arachidonic acid metabolism and may therefore have anti-inflammatory ...
K, Fogh, K, Kragballe, E, Larsen, H, Egsgaard, V K, Shukla   +4 more
openaire   +2 more sources

20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis

American Journal of Physiology-Heart and Circulatory Physiology, 2015
Endothelial cells play an important role in the process of coagulation and the function of platelets. We have previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid, increased platelet aggregation and induced hemostasis. The purpose of the present study is to investigate whether 20-HETE-mediated endothelial
Jiaxing, Wang, Hua, Li, Jinlong, He, Bochuan, Li, Qiankun, Bao, Xu, Zhang, Zhizhen, Lv, Youyi, Zhang, Jingyan, Han, Ding, Ai, Yi, Zhu   +10 more
openaire   +2 more sources

12-Hydroxyeicosatetraenoic acid reduces prostacyclin production by endothelial cells

Prostaglandins, 1986
12-Hydroxyeicosatetraenoic acid (12-HETE), a lipoxygenase product released by activated platelets and macrophages, reduced prostacyclin (PGI2) formation in bovine aortic endothelial cultures by as much as 70%. Maximal inhibition required 1 to 2 h to occur and after 2 hr, a concentration of 1 microM 12-HETE produced 80% of the maximum inhibitory effect.
C, Hadjiagapiou, A A, Spector
openaire   +2 more sources

Effect of hydroxyeicosatetraenoic acids on furosemide-sensitive chloride secretion in rat distal colon.

Journal of Pharmacology and Experimental Therapeutics, 2000
Arachidonic acid metabolites such as prostaglandins, thromboxanes, and leukotrienes are well known modulators of intestinal vascular perfusion, motility, and electrogenic ion transport.
M. Wegmann, Antje Kämpen, Susanne Weber, Hannsjörg W. Seyberth, A. Köckerling   +4 more
semanticscholar   +1 more source

Inhibition of Adenylyl Cyclases by 12(S)-Hydroxyeicosatetraenoic Acid

Biochemical and Biophysical Research Communications, 1996
The inhibition of adenylyl cyclase (AC) by a 12-lipoxygenase metabolite of arachidonic acid, 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), was investigated using three different kinds of cells: NRK-49F (normal rat kidney fibroblasts), AtT-20 (mouse pituitary tumor cell line) and HL-60 (human leukemia cells) cells. The inhibition was very
X.-Q. Wang, M. Otsuka, J. Takagi, Y. Kobayashi, F. Sato, Y. Saito   +5 more
openaire   +2 more sources

Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors

International Journal of Cancer, 1985
AbstractThe metabolism of arachidonic acid was investigated by radioimmunoassay and chromatographic techniques in 5 sarcomas and one embryonal carcinoma of human origin maintained as transplantable tumors in nude mice. The results obtained indicate that: (1) the absolute quantities of arachidonic acid metabolites produced by a given tumor varied ...
R A, Knazek, C L, Yee, J, Costa
openaire   +2 more sources

Conversion of 15-hydroxyeicosatetraenoic acid to 11-hydroxyhexadecatrienoic acid by endothelial cells

Biochemistry, 1988
Cultured endothelial cells take up 15-hydroxyeicosatetraenoic acid (15-HETE), a lipoxygenase product formed from arachidonic acid, and incorporate it into cellular phospholipids and glycerides. Uptake can occur from either the apical or basolateral surface.
X Y, Shen, P H, Figard, T L, Kaduce, A A, Spector   +3 more
openaire   +2 more sources