Results 231 to 240 of about 5,905,176 (286)

Electrospray mass spectrometric analysis of 5-hydroperoxy and 5-hydroxyeicosatetraenoic acids generated by lipid peroxidation of red blood cell ghost phospholipids

Journal of the American Society for Mass Spectrometry, 1998
Recent evidence suggests that generation of hydroxyl radicals in the presence of lipid membranes can lead to oxidation of arachidonic acid esterified to glycerophospholipids and the production of compounds isomeric to prostaglandins, thromboxanes, and ...
L. Hall, R. Murphy
semanticscholar   +1 more source

A practical enantioselective synthesis of 12-hydroxyeicosatetraenoic acids

Tetrahedron Letters, 1988
Abstract A practical enantioselective synthesis of 12(R)-HETE has been achieved from readily available starting materials. This process also constitutes a formal synthesis of Leukotriene B 4 .
Stevan W Djurić, Julie M Miyashiro, Thomas D Penning   +2 more
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Transformation and degradation of leukotriene B4, 12-hydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid induced by ultraviolet radiation.

Photodermatology, photoimmunology & photomedicine, 1992
To reveal the underlying mechanisms in the therapeutic effectiveness of ultraviolet (UBV)- and psoralen plus UVA phototherapy, the photostability of leukotriene B4 (LTB4), 12-hydroxyeicosatetraenoic acid (12-HETE) and 5-HETE was investigated in the presence and absence of photosensitizers (8-methoxypsoralen and 5-methoxypsoralen).
B, Lehmann, A, Kämpf, J, Barth
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Cerebral arteries can generate 5- and 15-hydroxyeicosatetraenoic acid from arachidonic acid

Canadian Journal of Physiology and Pharmacology, 1990
Products of the lipoxygenase pathway have been implicated in the development of the cerebrovascular spasm that arises after subarachnoid hemorrhage. In particular the hydroperoxyeicosatetranenoic acids (HPETEs), which are unstable and break down rapidly to the corresponding 5-hydroxy acids (HETEs), are vasoconstrictor agents that mimic some aspects of
R, Schulz, S, Jancar, D A, Cook
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Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid

Current Opinion in Nephrology and Hypertension, 2016
20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid and a key constituent of the microcirculation. Its effects on vascular function are multifaceted and include stimulation of smooth muscle, contractility, migration, and proliferation, as well as endothelial cell dysfunction and inflammation.
Victor, Garcia, Michal L, Schwartzman
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Hydroxyeicosatetraenoic acids (HETEs)

Progress in Lipid Research, 1988
A A, Spector, J A, Gordon, S A, Moore
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[31] 12-Hydroxyeicosatetraenoic acid and related compounds

1981
Publisher Summary This chapter describes the preparation and effects of 12-hydroxyeicosatetraenoic acid. 12- L -Hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) is one of the major metabolites of arachidonic acid in many tissues or organs. It is the enzymatic product of a novel lipoxygenase present in platelets, leukocytes, spleen, lung, skin, and ...
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Blockade of Receptor‐Mediated Cyclic GMP Formation by Hydroxyeicosatetraenoic Acid

Journal of Neurochemistry, 1987
AbstractReceptor‐mediated cyclic GMP formation in N1E‐115 murine neuroblastoma cells appears to involve oxidative metabolism of arachidonic acid. Evidence in support of this includes the blockade of this response by lipoxygenase inhibitors, e.g., eicosatetraynoic acid (ETYA) or other metabolic perturbants, e.g., methylene blue.
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5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism

Archives of Toxicology, 2016
Zaid H Maayah, A. El-Kadi
semanticscholar   +1 more source

Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signaling Pathways

1991
Phosphatidylinositol (PI) and phosphatidylcholine (PC), two major membrane phospholipids (PLs), participate in cell signaling. Their hydrolysis by activated phospholipases produces second messengers, one of which is diacylglycerol (DAG), an activator of protein kinase C which is involved in a variety of cellular responses (1–5).
Alain B. Legrand, John A. Lawson, John A. Oates   +2 more
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