Development of a Brain‐Penetrant Nurr1 Agonist Tool
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor +7 more
wiley +1 more source
Copper requirements and copper toxicity as niche-defining factors in the growth of terrestrial ammonia-oxidizing archaea and bacteria. [PDF]
FEMS Microbiol EcolOudova-Rivera B +3 more
europepmc +1 more source
Lighting the Path to Cyclic Phosphonamides via Halogen‐Bond Electron Donor–Acceptor Activation
Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.Cyclic phosphinamides are valuable scaffolds for optoelectronic applications, yet remain difficult to access with existing methods. Here, we highlight a mild and straightforward visible light‐driven strategy that enables the formation of cyclic phosphinamides and thiophosphinamides.
Clara Faure +8 more
wiley +1 more source
One-Pot Synthesis of Abietane-Type Hydroxamic Acids: Process Optimization and Mechanistic Insights. [PDF]
MoleculesMendoza-Hernández WE +3 more
europepmc +1 more source
Dual‐Site Catalysis in Electrocatalytic C–N Coupling: Challenges and Design Principles
ChemElectroChem, Volume 13, Issue 11, 3 June 2026.This review examines dual‐site catalysis in electrocatalytic C─N coupling through four recurring challenges: energetic barriers, kinetic mismatch, selectivity loss, and systemic constraints. It highlights how rationally designed dual‐site catalysts cooperatively lower reaction barriers, synchronize intermediate generation, suppress competing pathways ...
Tao You +3 more
wiley +1 more source
Base-Promoted C→N Carbonyl Shift Enables One-Step Access to aza-β-Lactams from α-Heteroaryl-α-amino Esters. [PDF]
Org LettKristek J, Št'astná N, Pospíšil J.
europepmc +1 more source
Nanodiamond Quantum Sensors for Probing Free Radical Biology
Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley +1 more source
Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach +4 more
wiley +2 more sources
Enantioselective Copper-Catalyzed Synthesis of Hydroxylamines via Hydrofunctionalization of Alkenes using Nitroalkanes. [PDF]
J Am Chem SocLaw JA +7 more
europepmc +1 more source
Advanced Materials, Volume 38, Issue 31, 2 June 2026.Catalyst coordination acts as a loaded dice biasing reaction selectivity. Single‐atom site catalysts lock intermediates in exposed configurations, enabling continued hydrogenation and favoring oxygen‐retaining products. In contrast, extended metal surfaces fully coordinate and shield reactive centers, promoting deoxygenation pathways. This work reveals
Chengyi Zhang, Ziyun Wang
wiley +1 more source