Results 231 to 240 of about 143,720 (300)

Mechanisms of haemoglobin mass expansion following heat stress

The Journal of Physiology, EarlyView.
Abstract figure legend Theorised mechanisms of heat stress‐induced erythropoiesis which may facilitate the expansion of haemoglobin mass. A, acute: heat stress‐induced renal ischaemia. Redistribution of blood flow away from the kidneys to facilitate thermoregulation during heat stress could reduce renal oxygen delivery, subsequently lowering renal PO2${
Elliott J. Jenkins, Brittany A. Edgett, Michael G. Hughes, Joshua C. Tremblay, Mike Stembridge   +4 more
wiley   +1 more source

Engineering Pseudomonas taiwanensis VLB120 for regio- and stereospecific hydroxylation of L-lysine fueled by the Weimberg pathway. [PDF]

Microb Cell Fact
Nerke P, Handke J, Hubmann G, Lütz S.
europepmc   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305. [PDF]

Rapid Commun Mass Spectrom
Kobidze G, Möller T, Wen HC, Busardò FP, Thevis M.   +4 more
europepmc   +1 more source

Cellular and functional insights into FIH-mediated hydroxylation of TRPA1. [PDF]

J Biol Chem
Guo T, Lopez DM, Wang S, Yao L, Li X, Davies ER, Vargas-Caballero M, Divecha N, Schofield CJ, Deinhardt K, Wang Y.   +10 more
europepmc   +1 more source

Trifunctional flavoenzyme-catalyzed asymmetric 4-alkyl-butenolide assembly in avenolide biosynthesis. [PDF]

Nat Commun
Li W, Zhao J, Zeng W, Zhang R, Yan L, Fan Y, Liu J, Wang W, Challis GL, Zhou S.   +9 more
europepmc   +1 more source

In vivo and in vitro metabolism of the designer benzodiazepine, bretazenil: a comparison of pooled human hepatocytes and liver microsomes with postmortem urine and blood samples. [PDF]

Arch Toxicol
Gameli PS, Kutzler J, Huppertz LM, Berardinelli D, Tronconi L, Basile G, Carlier J, Busardò FP, Auwärter V.   +8 more
europepmc   +1 more source

Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450_BM3. [PDF]

Nat Commun
Xu Y, Zhang K, Lv Q, Wang J, Li J.
europepmc   +1 more source

Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides. [PDF]

J Am Chem Soc
Palacios PM, Li X, Jaber Sathik Rifayee SB, Tang H, Karabencheva-Christova T, Christov C, Chang WC, Guo Y.   +7 more
europepmc   +1 more source