Results 51 to 60 of about 66,196 (244)

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

eLife, 2019
Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enzymes
Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe   +10 more
doaj   +1 more source

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase

Advanced Science, EarlyView.
Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang, Bumhan Ryu, Soyeon Park, Dong‐Heon Lee, Hyo Jin Hong, Jeong‐Geol Na, Chul Gyu Song, Hyun Goo Kang, Edwin Pozharski, Seung Jae Lee   +9 more
wiley   +1 more source

Green Polyols from Tamanu Seed Oil: Reaction Kinetics and Process Optimization

Communications in Science and Technology
Using methanol, this study examined the hydroxylation process of epoxidized tamanu seed oil (ETSO), with an oxirane number of 3.92 to 4.04 mmol/g, under the catalyzation of sulfuric acid (H2SO4).
Eni Budiyati, Mohammad Sofyan Habibburohman, Nur Ahmad Fauzi, Muhammad Azim Wasi, Malik Musthofa, Anisa Ur rahmah   +5 more
doaj   +1 more source

A Novel 3-Phytosterone-9α-Hydroxylase Oxygenation Component and Its Application in Bioconversion of 4-Androstene-3,17-Dione to 9α-Hydroxy-4-Androstene-3,17-Dione Coupling with A NADH Regeneration Formate Dehydrogenase

Molecules, 2019
9α-Hydroxy-4-androstene-3,17-dione (9-OH-AD) is one of the significant intermediates for the preparation of β-methasone, dexamethasone, and other steroids. In general, the key enzyme that enables the biotransformation of 4-androstene-3,17-dione
Xian Zhang, Manchi Zhu, Rumeng Han, Youxi Zhao, Kewei Chen, Kai Qian, Minglong Shao, Taowei Yang, Meijuan Xu, Jianzhong Xu, Zhiming Rao   +10 more
doaj   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

Mechanism of Efficient Smithsonite Flotation with a Ternary Composite Collector Under Sulfur-Free Conditions

Molecules
The increasing demand for zinc resources and the declining availability of sulfide zinc ore reserves have made the efficient utilization of zinc oxide a topic of considerable interest. In this study, a ternary composite collector ABN (Al-BHA-NaOL system)
Rui Li, Yanhai Shao, Jinhui Li, Chenjie Liu, Hongqin Chen, Xiao Meng, Xinru Jia   +6 more
doaj   +1 more source

On the heterogeneity of the mitochondrial C27-steroid 26-hydroxylase system

Journal of Lipid Research, 1976
Mitochondrial 26-hydroxylation of exogenous cholesterol, endogenous cholesterol, and 5β-cholestane-3α,7α,12α-triol was studied. 26-Hydroxylation of endogenous cholesterol was measured by mass fragmentography.
J Gustafsson
doaj   +1 more source

Laterally Oriented Dendritic Passivation via In Situ Zn Reconstruction for Stabilizing NiMo Catalysts under Dynamic Electrolysis

Advanced Science, EarlyView.
This study highlights the effectiveness of Zn‐induced dendrite layers in enhancing the durability of NiMo HER catalysts under dynamic electrochemical conditions. Through in situ dendritic passivation, the Zn‐NiMo catalyst preserves catalytic active sites and mitigates irreversible Ni oxidation/hydroxylation during repeated load fluctuation.
Taeyoung Jeong, Hyun‐Jae Park, Myeongjin Kim   +2 more
wiley   +1 more source