Results 51 to 60 of about 111,305 (353)

Native Endophytes of Tripterygium wilfordii-Mediated Biotransformation Reduces Toxicity of Celastrol

open access: yesFrontiers in Microbiology, 2022
Celastrol (1), obtained from the roots of Tripterygium wilfordii Hook F., is most likely to become an antitumor drug, but with severe cytotoxicity.
Ping-yang Ma   +8 more
doaj   +1 more source

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

open access: yesNature Communications, 2016
Mammalian transient receptor potential ankyrin 1 (TRPA1) is a polymodal nociceptor that plays an important role in pain generation, but its role as a cold nociceptor is still controversial.
Takahito Miyake   +10 more
semanticscholar   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

open access: yesAdvanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang   +3 more
wiley   +1 more source

On the heterogeneity of the mitochondrial C27-steroid 26-hydroxylase system

open access: yesJournal of Lipid Research, 1976
Mitochondrial 26-hydroxylation of exogenous cholesterol, endogenous cholesterol, and 5β-cholestane-3α,7α,12α-triol was studied. 26-Hydroxylation of endogenous cholesterol was measured by mass fragmentography.
J Gustafsson
doaj  

The regulatory mechanisms of proline and hydroxyproline metabolism: Recent advances in perspective

open access: yesFrontiers in Oncology, 2023
For diverse human tumors, growth and metastasis are dependent on proline synthesis, but the mechanisms underlying this association are not clear. Proline incorporated into collagen is primarily synthesized from glutamine.
James M. Phang
doaj   +1 more source

Tyrosine Hydroxylation in Betalain Pigment Biosynthesis Is Performed by Cytochrome P450 Enzymes in Beets (Beta vulgaris)

open access: yesPLoS ONE, 2016
Yellow and red-violet betalain plant pigments are restricted to several families in the order Caryophyllales, where betacyanins play analogous biological roles to anthocyanins. The initial step in betalain biosynthesis is the hydroxylation of tyrosine to
Rasika Sunnadeniya   +7 more
semanticscholar   +1 more source

Exceptional Thermal Conductivity in Printed Dielectrics through Compositional and Microstructural Design

open access: yesAdvanced Materials, EarlyView.
A multi‐generational compositional design creates a printable low‐loss dielectric composite that achieves over 16 W m−1 K−1. This breakthrough is enabled by thermal post‐processing, which promotes templated crystallization in a polymer matrix from surface‐modified particles, creating a “hetero‐percolated network.” The resulting material is three ...
Daniel J. Braconnier   +6 more
wiley   +1 more source

Characterization of 6 alpha-hydroxylation of taurochenodeoxycholic acid in pig liver.

open access: yesJournal of Lipid Research, 1988
The properties of the species-specific 6 alpha-hydroxylation of taurochenodeoxycholic acid were studied in subcellular fractions from pig liver. The hydroxylation was observed in microsomes but not in mitochondria.
H Boström
doaj  

Biotransformation of Isoflavone Using Enzymatic Reactions

open access: yesMolecules, 2013
The roles of cytochrome P450 monooxygenases (CYPs) from Streptomyces spp. which are called the “treasure islands” for natural products for medicine and antibiotics are not well understood.
Changhyun Roh
doaj   +1 more source

Specific Enhancement of Catalytic Activity by a Dicopper Core: Selective Hydroxylation of Benzene to Phenol with Hydrogen Peroxide.

open access: yesAngewandte Chemie, 2017
A dicopper(II) complex, stabilized by the bis(tpa) ligand 1,2-bis[2-[bis(2-pyridylmethyl)aminomethyl]-6-pyridyl]ethane (6-hpa), [Cu2 (μ-OH)(6-hpa)]3+ , was synthesized and structurally characterized.
Tomokazu Tsuji   +8 more
semanticscholar   +1 more source

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