Results 31 to 40 of about 85,771 (308)

Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in Escherichia coli

Frontiers in Bioengineering and Biotechnology, 2023
The hydroxylation is an important way to generate the functionalized derivatives of flavonoids. However, the efficient hydroxylation of flavonoids by bacterial P450 enzymes is rarely reported.
Baodong Hu, Baodong Hu, Baodong Hu, Baodong Hu, Xinrui Zhao, Xinrui Zhao, Xinrui Zhao, Xinrui Zhao, Jingwen Zhou, Jingwen Zhou, Jingwen Zhou, Jingwen Zhou, Jianghua Li, Jianghua Li, Jianghua Li, Jianghua Li, Jian Chen, Jian Chen, Jian Chen, Jian Chen, Guocheng Du, Guocheng Du, Guocheng Du, Guocheng Du, Guocheng Du   +24 more
doaj   +1 more source

Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols

Beilstein Journal of Organic Chemistry, 2021
A method for the synthesis of 9,11-secosteroids starting from the natural corticosteroid cortisol is described. There are two key steps in this approach, combining chemistry and synthetic biology.
Marek Kõllo, Marje Kasari, Villu Kasari, Tõnis Pehk, Ivar Järving, Margus Lopp, Arvi Jõers, Tõnis Kanger   +7 more
doaj   +1 more source

A Novel Antimalarial Metabolite in Erythrocyte From the Hydroxylation of Dihydroartemisinin by Cunninghamella elegans

Frontiers in Chemistry, 2022
Dihydroartemisinin (DHA) is a sesquiterpene endoperoxide with prominent antimalarial efficacy, which was discovered by Professor Youyou Tu through the reduction of artemisinin in the 1970s.
Yue Bai, Yifan Zhao, Xinna Gao, Dong Zhang, Yue Ma, Lan Yang, Peng Sun   +6 more
doaj   +1 more source

Fatty acid hydroxylation by CYP168A1.

, 2022
Fatty acid hydroxylation by CYP168A1.
Diane E. Kelly (7585250), Nicola J. Rolley (12269550), Vera Thoss (12269553), Nicolae Corcionivoschi (463527), Andrew G. S. Warrilow (7585244), Steven L. Kelly (215873), Josie E. Parker (7585247), Claire L. Price (12269547)   +7 more
core   +1 more source

Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure

Beilstein Journal of Organic Chemistry, 2012
The hydroxylation of n-alkanes, which proceeds in the presence of a P450-monooxygenase advantageously at temperatures significantly below room temperature, is described.
Svenja Staudt, Christina A. Müller, Jan Marienhagen, Christian Böing, Stefan Buchholz, Ulrich Schwaneberg, Harald Gröger   +6 more
doaj   +1 more source

Hydroxylation Kinetics of Epoxidized Tung Oil Using Methanol as Nucleophilic Agent

International Journal of Technology, 2023
The synthesis of vegetable oil-based polyols has been carried out through the epoxidation-hydroxylation process. However, Tung oil has never been explored in the process, even though Tung oil has a high double bond.
Eni Budiyati, Rochmadi, Arief Budiman, Budhijanto   +3 more
doaj   +1 more source

Enzyme-Like Hydroxylation of Aliphatic C–H Bonds From an Isolable Co-Oxo Complex

, 2021
Selective hydroxylation of aliphatic C–H bonds remains a challenging but broadly useful transformation. Nature has evolved systems that excel at this reaction, exemplified by cytochrome P450 enzymes which use an iron-oxo intermediate to activate ...
John, Anderson, Joseph, Schneider, Kate, Jesse, Alexander, Filatov, McKenna, Goetz   +4 more
core   +1 more source

Recent Advances and Challenges in the Production of Hydroxylated Natural Products Using Microorganisms

Fermentation
Hydroxylation reaction is a significant source of structural diversity in natural products (NPs), playing a crucial role in improving the bioactivity, solubility, and stability of natural product molecules.
Chang Sun, Rumei Zeng, Tianpeng Chen, Yibing Yang, Yi Song, Qiang Li, Jie Cheng, Bingliang Liu   +7 more
doaj   +1 more source

Chiral Primary Amine/Ketone Cooperative Catalysis for Asymmetric α-Hydroxylation with Hydrogen Peroxide

, 2020
Carbonyl and amine are yin and yang in organocatalysis that mutually activate and transform each other. As intrinsically reacting partners, carbonyl and amine tend to condensate, depleting their individual activity when employed as catalysts.
Mao, Cai, Kaini, Xu, Sanzhong, Luo, zongxiu, nie, Yuze, Li, Long, Zhang   +5 more
core   +1 more source

Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous

Beilstein Journal of Organic Chemistry, 2012
The ability of Rhodococcus rhodochrous (NCIMB 9703) to catalyse the regio- and stereoselective hydroxylation of a range of benzyloxy-substituted heterocycles has been investigated.
Elaine O’Reilly, Suzanne J. Aitken, Gideon Grogan, Paul P. Kelly, Nicholas J. Turner, Sabine L. Flitsch   +5 more
doaj   +1 more source