Results 51 to 60 of about 3,705 (210)

Purification, characterization, crystallisation and X‐ray analysis of selenomethionine‐labelled hydroxymethylbilane synthase from Escherichia coli [PDF]

European Journal of Biochemistry, 1993
Hydroxymethylbilane synthase (HMBS) catalyses the conversion of porphobilinogen into hydroxymethylbilane, a linear tetrapyrrolic intermediate in the biosynthesis of haems, chlorophylls, vitamin B12 and related macrocyles. In the course of an investigation of the crystal structure of this enzyme, we intended to follow a new strategy to obtain the X‐ray ...
Alfons Hädener, P. K. Matzinger, V.N. Malashkevich, Gordon V. Louie, Stephen P. Wood, Phillip Oliver, Peter R. Alefounder, Andrew R. Pitt, Chris Abell, Alan R. Battersby   +9 more
openalex   +7 more sources

Acute Intermittent Porphyria in a Man with Dual Enzyme Deficiencies

Case Reports in Genetics, 2020
Porphyrias are a heterogeneous group of metabolic disorders that result from the altered activity of specific enzymes of the heme biosynthetic pathway and are characterized by accumulation of pathway intermediates.
G. N. Cerbino, L. Abou Assali, L. S. Varela, L. Tomassi, A. Batlle, V. E. Parera, M. V. Rossetti   +6 more
doaj   +1 more source

Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Microbial Cell Factories, 2023
Background Heme is an iron/porphyrin complex compound, widely used in the health care, food, and pharmaceutical industries. It is more advantageous and attractive to develop microbial cell factories to produce heme by fermentation, with lower production ...
Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong, Zhengquan Gao   +9 more
doaj   +1 more source

Selection of internal reference genes for SYBR green qRT-PCR studies of rhesus monkey () tissues [PDF]

, 2008
Background: The rhesus monkey (Macaca mulatta) is a valuable and widely used model animal for biomedical research. However, quantitative analyses of rhesus gene expression profiles under diverse experimental conditions are limited by a shortage of ...
K Ahn, Jae Won Huh, Sang Je Park, Dae Soo Kim, H S Ha, Y J Kim, J R Lee, Kyu Tae Chang, H S Kim   +8 more
core   +1 more source

Patterns in evolutionary origins of heme, chlorophyll a and isopentenyl diphosphate biosynthetic pathways suggest non-photosynthetic periods prior to plastid replacements in dinoflagellates [PDF]

, 2018
BackgroundThe ancestral dinoflagellate most likely established a peridinin-containing plastid, which have been inherited in the extant photosynthetic descendants.
Inagaki Yuji, Matsuo Eriko, 稲垣 祐司   +2 more
core   +2 more sources

The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci [PDF]

, 2017
The regulatory mechanisms involved in lipogenesis and triacylglycerol (TAG) accumulation are largely unknown in oleaginous rhodococci. In this study a regulatory protein (here called NlpR: Nitrogen lipid Regulator), which contributes to the modulation of
Alvarez, Hector Manuel, Gago, Gabriela Marisa, Gramajo, Hugo Cesar, Hernández, Martín Alejandro, Lara, María Julia   +4 more
core   +1 more source

Identification of Suitable Reference Genes for Real Time Quantitative Polymerase Chain Reaction Assays on Pectoralis major Muscle in Chicken (Gallus gallus ). [PDF]

PLoS ONE, 2015
Thirteen reference genes were investigated to determine their stability to be used as a housekeeping in gene expression studies in skeletal muscle of chickens.
Carlos S Nascimento, Leandro T Barbosa, Claudson Brito, Roberta P M Fernandes, Renata S Mann, Ana Paula G Pinto, Haniel C Oliveira, Mike V Dodson, Simone E F Guimarães, Marcio S Duarte   +9 more
doaj   +1 more source

A Perfect Storm: Abdominal Pain and Ileus Explained by Acute Intermittent Porphyria Caused by Prehospitalization and Intrahospitalization Factors

Journal of Investigative Medicine High Impact Case Reports, 2022
Acute intermittent porphyria (AIP) is a rare autosomal dominant inherited disease, predominantly seen in female patients, caused by mutations in the hydroxymethylbilane synthase gene.
Andrew J. Ortega DO, Sundar Cherukuri DO, M. Ammar Kalas MD, Brian Lee DO, Jesus Guzman MD, Alejandro Robles MD, Marc J. Zuckerman MD, Ihsan Al-Bayati MD   +7 more
doaj   +1 more source

A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T [PDF]

, 2012
BACKGROUND: Natrialba magadii is an aerobic chemoorganotrophic member of the Euryarchaeota and is a dual extremophile requiring alkaline conditions and hypersalinity for optimal growth. The genome sequence of Nab.
Diego E Sastre, Friedhelm Pfeiffer, Jean F Challacombe, John C Detter, Julie A Maupin-Furlow, Karen W Davenport, Lynne A Goodwin, María I Giménez, Nikos Kyrpides, Roberto A Paggi, Rosana E DeCastro, Roxanne Tapia, Samuel Pitluck, Shivakumara Siddaramappa, Susan Lucas, Tanja Woyke   +15 more
core   +2 more sources

Characterization of a new mutation (R292G) and a deletion at the human uroporphyrinogen decarboxylase locus in two patients with hepatoerythropoietic porphyria [PDF]

, 1992
A deficiency in the activity of uroporphyrinogen decarboxylase (UROD), the fifth enzyme of the haem biosynthetic pathway, is found in familial porphyria cutanea tarda (F-PCT) and hepatoerythropoietic porphyria (HEP). A new mutation (R292G) and a deletion
Bourgeois, F. (Francine), Grandchamp, B. (Bernard), Nordmann, Y. (Yves), Rooij, F.W.M. (Felix) de, Siersema, P.D. (Peter), Verneuil1, H. (Hubert) de, Wilson, J.H.P. (Paul)   +6 more
core   +1 more source