Results 71 to 80 of about 164,160 (174)

The effect of mitoTEMPO on the development of hypoxia‐induced pulmonary hypertension in male mice

Physiological Reports, Volume 14, Issue 5, March 2026.
MitoTEMPO targets mitochondrial superoxide (O2•−) but showed no protective effect on chronic hypoxia–induced pulmonary hypertension. Pulmonary artery remodeling and right ventricular remodeling developed despite treatment. Abstract Mitochondrial reactive oxygen species (mtROS) have been implicated in the development of chronic hypoxia‐induced pulmonary
Esraa M. Zeidan, Sai Aparna Nagarajan, Akylbek Sydykov, Jens Bier, Monika Brosien, Ashraf Taye, Oleg Pak, Hossein A. Ghofrani, Ralph Theo Schermuly, Werner Seeger, Norbert Weissmann, Natascha Sommer, Claudio Nardiello   +12 more
wiley   +1 more source

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]

, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Meja Rabodonirina, Chiara Atzori, Benfield, T, Helweg-Larsen, J, Rabodonirina, Meja, Robert Miller, Crothers, KA, Thomas Benfield, Huang, Laurence, Atzori, C, Rabodonirina, M, Laurence Huang, Kristina Crothers, Miller, R, Haung, L, Helweg-Larsen, Jannik, Jannik Helweg-Larsen, Miller, Robert, Crothers, Kristina, Benfield, Thomas, Atzori, Chiara   +20 more
core   +1 more source

Acute intermittent porphyria: a disease with low penetrance and high heterogeneity

Frontiers in Genetics
Acute intermittent porphyria (AIP) is caused by mutations in the gene encoding hydroxymethylbilane synthase (HMBS), a key enzyme in the heme biosynthesis pathway.
Jia-Jia Lei, Shuang Li, Bai-Xue Dong, Jing Yang, Yi Ren   +4 more
doaj   +1 more source

Liver Transplantation and Other Hepatically Directed Therapies Do Not Change the Biochemical Phenotype nor Halt Progression of Leukodystrophy due to Biallelic HMBS Variants: A Case Report

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Leukodystrophy due to biallelic HMBS variants is a rare condition distinct from acute intermittent porphyria (AIP). It is characterised by progressive leukoencephalopathy rather than acute attacks of neurovisceral symptoms. We report the ongoing clinical progression of a patient with leukodystrophy due to homozygous variants in HMBS [c.251C>A,
Jeremy Clark, Joel Smith, Yoke Leong, Virginia Cronin, Ingrid Winship, Gayle Ross, Timothy Fazio   +6 more
wiley   +1 more source

Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae [PDF]

, 2009
Aspergillus westerdijkiae is the main producer of several biologically active polyketide metabolites including isoasperlactone and asperlactone. A 5298 bp polyketide synthase gene ‘‘aomsas” has been cloned in Aspergillus westerdijkiae by using gene ...
Atoui, Ali, Dobson, Alan D. W., Mathieu, Florence, Puel, Olivier, Dao, Huy Phong, Liboz, Thierry, O’Callaghan, John, O'Callaghan, John, Bacha, Nafees, Dobson, Alan D.W., Lebrihi, Ahmed   +10 more
core   +1 more source

Expression Signatures of Vascular Complication‐Associated Proteins in Type 2 Diabetes: A Multiomics Analysis From the FIELD Study

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Aims The aim of the study is to integrate targeted transcriptomic analyses of previously identified biomarker proteins (proteomic findings) to better understand vascular complications (Cx) in Type 2 diabetes (T2D). Methods Total RNA was extracted from baseline citrate plasma samples of 543 individuals with T2D from the Fenofibrate Intervention and ...
Habib Francis, Andrzej S. Januszewski, Abubakar S. Mangani, Matthew B. O′Rourke, Michael L. H. Huang, Fahmida K. Ema, Anandwardhan A. Hardikar, Mugdha V. Joglekar, David R. Sullivan, Ronald C. W. Ma, Sanjeev Galande, Val Gebski, Michael d′Emden, R. John Simes, Alicia J. Jenkins, Mark P. Molloy, Anthony C. Keech, Hannah Wesley   +17 more
wiley   +1 more source

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

Indian Journal of Dermatology, 2014
Background: Papillomatosis is a known histopathologic pattern usually seen in human papillomavirus (HPV) infection and verruca vulgaris is the typical example.
Kamyab Hesari Kambiz, Davoodi Kaveh, Damavandi Maede, Ayatollahi Hossein, Aghazadeh Nessa, Rahbar Ziba, Ghanadan Alireza   +6 more
doaj   +1 more source

Validation of Suitable Reference Genes for Gene Expression Studies on Yak Testis Development

Animals, 2020
Testis has an important function in male reproduction. Its development is regulated by a large number of genes. The real-time reserve transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a useful tool to evaluate the gene expression levels ...
Xuelan Zhou, Xiaoyun Wu, Min Chu, Chunnian Liang, Xuezhi Ding, Jie Pei, Lin Xiong, Pengjia Bao, Xian Guo, Ping Yan   +9 more
doaj   +1 more source

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec, Yeranuhi Hovhannisyan, Gaëlle Revet, Sila Polat, Medhi Hassani, Nathalie Mougenot, Inès Barthelemy, Stephane Blot, Caroline Cieniewski‐Bernard, Arnaud Ferry, Ekaterini Kordeli, Zhenlin Li, Onnik Agbulut   +12 more
wiley   +1 more source

ADAR1 mRNA quantification for predicting HSIL in persons with HIV and abnormal anal cytology

International Journal of Cancer, Volume 157, Issue 9, Page 1939-1947, 1 November 2025.
What's new? This study introduces ADAR1 mRNA quantification as a promising biomarker for improving high‐grade squamous intraepithelial lesion (HSIL) prediction in HIV‐positive individuals with abnormal anal cytology. With 92% specificity, it reduces unnecessary high‐resolution anoscopies (HRA) by 77%, offering a more efficient and targeted screening ...
Melissa Bello‐Perez, Paula Mascarell, Marta Fernández‐González, Jose Alberto García, Ana Gutiérrez‐Ortiz de la Tabla, Christian Ledesma, Alba De la Rica, Antonio Galiana, Leo López, Maria Dolores Ocete, Carme Salvador, Concepción Gimeno, Javier García‐Abellán, Sergio Padilla, Félix Gutiérrez, Mar Masiá   +15 more
wiley   +1 more source