Results 91 to 100 of about 3,705 (210)

Effects of Trichostatin A on drug uptake transporters in primary rat hepatocyte cultures [PDF]

The present study was set up to investigate the effects of Trichostatin A (TSA), a prototypical epigenetic modifier, on the expression and activity of hepatic drug uptake transporters in primary cultured rat hepatocytes.
Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +3 more
core   +1 more source

Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi [PDF]

, 1982
Heme biosynthesis in fungal host strains has acquired considerable interest in relation to the production of secreted heme-containing peroxidases.
Weert, S. de, Punt, P.J., Lokman, B.C., Hondel, C.A. van den, Franken, A.C., Ram, Arthur F.J., Ram, A.F.   +6 more
core   +2 more sources

Acute intermittent porphyria: a disease with low penetrance and high heterogeneity

Frontiers in Genetics
Acute intermittent porphyria (AIP) is caused by mutations in the gene encoding hydroxymethylbilane synthase (HMBS), a key enzyme in the heme biosynthesis pathway.
Jia-Jia Lei, Shuang Li, Bai-Xue Dong, Jing Yang, Yi Ren   +4 more
doaj   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids [PDF]

, 2017
Treatment of common bile duct disorders such as biliary atresia or ischaemic strictures is limited to liver transplantation or hepatojejunostomy due to the lack of suitable tissue for surgical reconstruction.
Alexander, Graeme J., Bargehr, Johannes, Berntsen, Natalie Lie, Bertero, Alessandro, Brown, Stephanie, Casey, John, Davies, Susan E., de Brito, Miguel Cardoso, Gelson, William T.H., Georgakopoulos, Nikitas, Gieseck, Richard L., Godfrey, Edmund M., Gómez-Vázquez, María J., Hannan, Nicholas R.F., Jensen, Kim B., Justin, Alexander W., Karlsen, Tom H., Madrigal, Pedro, Markaki, Athina E., Materek, Paulina M., Melum, Espen, Ortmann, Daniel, Pawlowski, Matthias, Pedersen, Marianne T., Pirmadjid, Negar, Rimland, Casey A., Ross, Alexander, Saeb-Parsy, Kourosh, Sampaziotis, Fotios, Sawiak, Stephen, Shu, Wenmiao, Simonic, Ingrid, Sinha, Sanjay, Skeldon, Gregor M., Snijders, Kirsten, Tysoe, Olivia C., Upponi, Sara S., Valestrand, Laura, Vallier, Ludovic, Wynn, Thomas A., Yiangou, Loukia, Zilbauer, Matthias, Zonneveld, Mariëlle C.F.   +42 more
core   +7 more sources

Mitochondrial Dysfunction and Defects in Mitochondrial Adaptation to Exercise Training in the Muscle of Patients With COPD: Disease Versus Disuse

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Chronic obstructive pulmonary disease (COPD) is frequently associated with skeletal muscle dysfunction, having a considerable impact on exercise tolerance and patient prognosis. Mitochondria play a role in skeletal muscle weakness and exercise intolerance in COPD, but the majority of studies on mitochondrial function are biased by the fact
Aldjia Abdellaoui, Farés Gouzi, Cécile Notarnicola, Annick Bourret, Amandine Suc, Dalila Laoudj‐Chenivesse, Nelly Héraud, Jacques Mercier, Christian Préfaut, Maurice Hayot, Pascal Pomiès   +10 more
wiley   +1 more source

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

Indian Journal of Dermatology, 2014
Background: Papillomatosis is a known histopathologic pattern usually seen in human papillomavirus (HPV) infection and verruca vulgaris is the typical example.
Kamyab Hesari Kambiz, Davoodi Kaveh, Damavandi Maede, Ayatollahi Hossein, Aghazadeh Nessa, Rahbar Ziba, Ghanadan Alireza   +6 more
doaj   +1 more source

Meatal Swabs Contain Less Cellular Material and Are Associated with a Decrease in Gram Stain Smear Quality Compared to Urethral Swabs in Men [PDF]

, 2017
Urethral swabs are the samples of choice for point-of-care Gram stain testing to diagnose Neisseria gonorrhoeae infection and nongonococcal urethritis (NGU) in men.
Aaron, Kristal J., Hook, Edward W., III, Jordan, Stephen J., Schwebke, Jane R., Van Der Pol, Barbara   +4 more
core   +1 more source

Gene Dosage Sensitivity and Human Genetic Diseases

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Here we review the historical background and contemporary insights into genetic dominance, focusing on haploinsufficiency (HI), that is, when the function of only one allele of a gene is not enough to ensure a normal phenotype in a diploid organism.
Reiner A. Veitia, Johannes Zschocke, James A. Birchler   +2 more
wiley   +1 more source

Transcriptomic study in explanted liver from a patient with acute intermittent porphyria

JIMD Reports, 2023
Acute intermittent porphyria (AIP) is a rare disease caused by a deficiency of hydroxymethylbilane synthase (HMBS), the third enzyme of the heme‐synthesis pathway. Decreased enzymatic activity in the liver induces an overproduction of heme‐precursors and
Jordi To‐Figueras, Esther Titos, Paula Aguilera, Alba Díaz, Javier Muñoz‐Luque, Irene Madrigal, Celia Badenas, Mercè Torra, Constantino Fondevila, Jordi Colmenero   +9 more
doaj   +1 more source