Results 81 to 90 of about 3,705 (210)

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources

The effect of mitoTEMPO on the development of hypoxia‐induced pulmonary hypertension in male mice

Physiological Reports, Volume 14, Issue 5, March 2026.
MitoTEMPO targets mitochondrial superoxide (O2•−) but showed no protective effect on chronic hypoxia–induced pulmonary hypertension. Pulmonary artery remodeling and right ventricular remodeling developed despite treatment. Abstract Mitochondrial reactive oxygen species (mtROS) have been implicated in the development of chronic hypoxia‐induced pulmonary
Esraa M. Zeidan, Sai Aparna Nagarajan, Akylbek Sydykov, Jens Bier, Monika Brosien, Ashraf Taye, Oleg Pak, Hossein A. Ghofrani, Ralph Theo Schermuly, Werner Seeger, Norbert Weissmann, Natascha Sommer, Claudio Nardiello   +12 more
wiley   +1 more source

Acute intermittent porphyria: a test of clinical acumen

Journal of Community Hospital Internal Medicine Perspectives, 2017
Acute intermittent porphyria (AIP) is a rare autosomal dominant hepatic porphyria due to deficiency of hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase leading to accumulation of porphyrin precursors.
Rashmi Dhital, Sijan Basnet, Dilli Ram Poudel, Khema Raj Bhusal   +3 more
doaj   +1 more source

Cytological, physiological and transcriptomic analysis of variegated Leaves in Primulina pungentisepala offspring

BMC Plant Biology, 2022
Background Primulina pungentisepala is suitable for use as a potted plant because of its beautiful leaf variegation, which is significantly different in its selfed offspring. However, the mechanism of P. pungentisepala leaf variegation is unclear.
Jiancun Chen, Yueya Li, Dong He, Meng Bai, Bo Li, Qixiang Zhang, Le Luo   +6 more
doaj   +1 more source

Simian varicella virus infects enteric neurons and α4β7 integrin-expressing gut-tropic T-cells in nonhuman primates [PDF]

, 2018
The pathogenesis of enteric zoster, a rare debilitating complication of reactivation of latent varicella-zoster virus (VZV) in the enteric nervous system (ENS), is largely unknown.
Mahalingam, R. (Ravi), Mehraban, T. (Tamana), Ouwendijk, W.J.D. (Werner), van Veen, S. (Suzanne), Verjans, G.M.G.M. (George)   +4 more
core   +4 more sources

Acute Intermittent Porphyria: Flaccid Quadriplegia and Encephalopathy due to Posterior Reversible Encephalopathy Syndrome (PRES) [PDF]

Liaquat National Journal of Primary Care
A deficiency of the enzyme HMB Hydroxymethylbilane synthase function, also known as porphobilinogen deaminase, leads to the emergence of acute intermittent porphyria (AIP). AIP is an uncommon form of hepatic porphyria inherited in an autosomal dominant
Saba Zaidi, Ayesha Abdul Samad, Ayesha Jaka   +2 more
doaj   +1 more source

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec, Yeranuhi Hovhannisyan, Gaëlle Revet, Sila Polat, Medhi Hassani, Nathalie Mougenot, Inès Barthelemy, Stephane Blot, Caroline Cieniewski‐Bernard, Arnaud Ferry, Ekaterini Kordeli, Zhenlin Li, Onnik Agbulut   +12 more
wiley   +1 more source

Meta-analysis of the Cepheid Xpert® CT/NG assay for extragenital detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections. [PDF]

, 2019
Background Most studies evaluating extragenital testing performance for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) detection by the Xpert® CT/NG show high per cent agreement with comparison assays; however, the precision around positive ...
Bristow, Claire C, Klausner, Jeffrey D, Little, Susan J, Mehta, Sanjay R, Morris, Sheldon R   +4 more
core  

Validation of Suitable Reference Genes for Gene Expression Studies on Yak Testis Development

Animals, 2020
Testis has an important function in male reproduction. Its development is regulated by a large number of genes. The real-time reserve transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a useful tool to evaluate the gene expression levels ...
Xuelan Zhou, Xiaoyun Wu, Min Chu, Chunnian Liang, Xuezhi Ding, Jie Pei, Lin Xiong, Pengjia Bao, Xian Guo, Ping Yan   +9 more
doaj   +1 more source

Screening of Reference Genes for RT-qPCR in Chicken Adipose Tissue and Adipocytes

Frontiers in Physiology, 2021
Reverse transcription quantitative real-time PCR is the most commonly used method to detect gene expression levels. In experiments, it is often necessary to correct and standardize the expression level of target genes with reference genes.
Wei Na, Wei Na, Wei Na, Wei Na, Yuxiang Wang, Yuxiang Wang, Yuxiang Wang, Pengfei Gong, Pengfei Gong, Pengfei Gong, Xinyang Zhang, Xinyang Zhang, Xinyang Zhang, Ke Zhang, Ke Zhang, Ke Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Ning Wang, Ning Wang, Ning Wang, Hui Li, Hui Li, Hui Li   +24 more
doaj   +1 more source