Results 181 to 190 of about 13,094 (219)

Effect of Hydroxymethylglutaryl-CoA Reductase Inhibitors on the Functional Properties of Erythrocyte Membranes

Experimental and Molecular Pathology, 1993
We studied 56 patients affected by primary hypercholesterolemia treated with placebo for 1 month and with simvastatin (20 mg/day) or pravastatin (20 mg/day) for 6 months during a double-blind clinical trial. At 1-month intervals we determined the following parameters in the serum: total and HDL cholesterol, triglycerides, and apolipoprotein A-1 and B ...
R. A. Rabini, M Polenta, R. Staffolani, M. Tocchini, Roberto Signore, I Testa, Laura Mazzanti   +6 more
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The effect of substrates and competitive inhibitors on the phosphatase-dependent activation of hepatic hydroxymethylglutaryl CoA reductase

Archives of Biochemistry and Biophysics, 1986
Previous studies have demonstrated that the in vitro activation of microsomal hepatic hydroxymethylglutaryl (HMG) CoA reductase by dephosphorylation is inhibited by HMG CoA or NADPH, the substrates of HMG CoA reductase (13). In the present study the effect of three competitive inhibitors of HMG CoA reductase on the activation of HMG CoA reductase was ...
Kenneth R. Feingold, Arthur H. Moser
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Effect of hydroxymethylglutaryl-CoA reductase inhibitors on low-density lipoprotein cholesterol, interleukin-6, and high-sensitivity C-reactive protein in end-stage renal disease.

Iranian journal of kidney diseases, 2011
INTRODUCTION. This study was conducted to determine the effect of statins on the serum levels of interleukin-6 (IL-6), low-density lipoprotein cholesterol (LDLC), and high-sensitivity C-reactive protein (HSCPR). MATERIALS AND METHODS. This randomized clinical trial was carried out on 95 hemodialysis patients divided into three groups of atorvastatin ...
Alireza Soliemani, Hassan Nikoueinejad, Mashallah Tabatabaizade, Elaheh Mianehsaz, Mohamad-Reza Tamadon   +4 more
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Serum levels of lipoprotein(a) and homocysteine in patients on hemodialysis who take hydroxymethylglutaryl-CoA reductase inhibitors, vitamin B6, and folic acid.

Iranian journal of kidney diseases, 2009
High serum levels of lipoprotein(a) and homocysteine are risk factors of cardiovascular disease which are prevalent in patients on hemodialysis. Controversy exists about the effects of hydroxymethylglutaryl-CoA reductase inhibitors on serum lipoprotein(a) levels in patients on hemodialysis.
Mir Hatef Shojaei, Mamhmoud Djalali, Fereydoun Siassi, Mohammad Reza Khatami, Mohammad Ali Boroumand, Mohammad Reza Eshragian   +5 more
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Action of 3-Hydroxymethylglutaryl CoA Reductase Inhibitors on ABCA-1 Protein (ATP-Binding Cassette Transporter-1) in Endothelial Cells Stimulated with Uremic Serum

Journal of the American Society of Nephrology, 2023
Marcelo C. Batista, Beata Marie Redublo Quinto   +1 more
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1.P.188 Extended-release niacin with or without inhibitors of hydroxymethylglutaryl CoA reductase: Improvement in dyslipidemia with minimal effect on transaminases

Atherosclerosis, 1997
John R. Guyton, Cathal O’Connor, Anne C. Goldberg, Robert A. Kreisberg, Dennis L. Sprecher, H. Robert Superko   +5 more
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[Hydroxymethylglutaryl CoA reductase inhibitors. A new group of substances for lowering a high cholesterol level].

Medizinische Monatsschrift fur Pharmazeuten, 1988
Uhl D
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Angiotensin converting enzyme (ACE) and HydroxyMethylGlutaryl-CoA (HMG-CoA) reductase inhibitors in the forefront of pharmacology of endothelium.

Pharmacological reports : PR, 2010
Healthy endothelium is essential for undisturbed functioning of the cardiovascular system, while endothelial dysfunction leads to its various pathologies. For example endothelial dysfunction precedes clinical symptoms of atherothrombosis, such as acute coronary syndrome, ischemic stroke, peripheral arterial disease or diabetic microangiopathies e.g ...
Stefan, Chłopicki, Ryszard J, Gryglewski   +1 more
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The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

High cholesterol and triglyceride levels are mainly related to further generation of life-threating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
Gulcan, Hayrettin Ozan, Yigitkan, Serkan, Orhan, Ilkay Erdogan   +2 more
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Ampere-level current density ammonia electrochemical synthesis using CuCo nanosheets simulating nitrite reductase bifunctional nature

Nature Communications, 2022
, , Yao-Yin Lou
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