Results 1 to 10 of about 271 (119)

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

Evaluation of a non‐radioactive rapid test for determination of serum progesterone in South American camelids

Veterinary Record, EarlyView.
Abstract Background Determination of the serum progesterone (P4) concentration is of high importance in reproductive medicine and may be applied for diagnosing pregnancy in South American camelids. P4 measurements in alpacas and llamas are usually performed using immunoassays, which are time consuming and require appropriate expertise of laboratory ...
Lina Längerer, Gerhard Schuler, Philipp Pohlscheid, Henrik Wagner, Kathrin Büttner, Axel Wehrend   +5 more
wiley   +1 more source

A Scoping Review of Certified Nurse‐Midwife and Certified Midwife Care in the United States: Assessing Outcomes Across Six Patient Care Domains

The Milbank Quarterly, EarlyView.
Policy Points Certified nurse‐midwife (CNM)/certified midwife (CM) care is associated with outcomes that are comparable or improved compared to physician care across multiple domains of health care quality, especially safety and effectiveness. CNM/CM care is consistently associated with lower rates of intrapartum interventions and improved birth ...
EMMA VIRGINIA CLARK, ROBYN SCHAFER, RACHEL LANE WALDEN, JULIE BLUMENFELD, CARRIE E. NEERLAND, KATIE PAGE, MAVIS N. SCHORN, SANJANA CHIMATA, HEATHER M. BRADFORD   +8 more
wiley   +1 more source

Prenatal 17‐Alpha‐Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14‐Year Follow‐Up of a Randomised Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Long‐term child outcomes after intra‐uterine exposure to 17‐alpha‐hydroxyprogesterone caproate (17‐OHPC) versus placebo. Design Follow‐up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17‐OHPC injections compared to placebo in multiple pregnancies. Setting Multicentre. Population or Sample Children
Emilie V. J. van Limburg Stirum, Marjon A. de Boer, A. C. J. Ravelli, Rik van Eekelen, Aleid G. Leemhuis, Martijn J. J. Finken, Cornelieke S. H. Aarnoudse‐Moens, Anneloes L. van Baar, Noor E. Simons, Rebecca C. Painter, Arianne C. Lim, Ben W. Mol, Eva Pajkrt, Martijn A. Oudijk, Janneke van 't Hooft   +14 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming, Abdul‐Akim Guseinov, Irina G. Tikhonova, Graeme Milligan, Nicole A. Perry‐Hauser   +4 more
wiley   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Rare Association Between Neurofibromatosis Type 1 and Adrenocortical Carcinoma

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Axial slice CT abdomen pelvis with portal venous contrast, revealing a well circumscribed 22 × 20 × 22 mm left adrenocortical adenocarcinoma (ACC) in a patient with neurofibromatosis type 1 (NF1). ABSTRACT Although rare, adrenocortical carcinoma (ACC) should be considered in individuals with neurofibromatosis type 1 (NF1) presenting with adrenal ...
Zachary Pluim, Joseph Do Woong Choi, Benedict Kakala, Jessica Wong, Roderick Clifton‐Bligh, Mark Sywak, Julie Howle   +6 more
wiley   +1 more source

OUABAIN RECEPTOR BINDING OF HYDROXYPROGESTERONE DERIVATIVES [PDF]

British Journal of Pharmacology, 1979
A specific and sensitive radioreceptor assay has been devised which is based on high affinity, saturable binding of 9 nm[3H]‐ouabain to the total particulate fraction isolated from dog heart. Ouabain and other cardiac glycosides, including the aglycones, were about equipotent in their ability to displace [3H]‐ouabain from its receptor, the IC50s ...
E, Chow, R S, Kim, F S, Labella, G, Queen   +3 more
openaire   +2 more sources

Molecular and Endocrine Regulation of Ovarian Maturation in the Black Tiger Prawn (Penaeus monodon) and Associated Challenges in Its Aquaculture

Reviews in Aquaculture, Volume 18, Issue 2, March 2026.
ABSTRACT Over the past four decades, substantial research has investigated the regulation of ovarian maturation and spawning in the black tiger prawn (Penaeus monodon). In this species, female reproduction is strongly suppressed by gonad‐inhibiting hormone (GIH) released from the eyestalk, making eyestalk ablation (ESA) the most widely adopted spawning‐
Gourab Chowdhury, Josephine Nocillado, Abigail Elizur, Scott F. Cummins, Tomer Ventura   +4 more
wiley   +1 more source