Results 71 to 80 of about 14,689 (241)

Rapid tools to gain insights into the interaction dynamics of new 8‐hydroxyquinolines with few fungal lines

Chemical Biology and Drug Design, 2018
The combination of tools such as time‐kill assay with subsequent application of mathematical modeling can clarify the potential of new antimicrobial compounds, since minimal inhibitory concentration (MIC) value does not provide a very detailed ...
A. R. Joaquim, B. Pippi, Maycon Antonio de Cesare, D. A. Rocha, R. Boff, K. Staudt, T. Ruaro, A. Zimmer, Bibiana Verlindo de Araújo, G. Silveira, A. F. Martins, M. L. Teixeira, Francisco P. dos Santos, A. Fuentefria, S. F. de Andrade   +14 more
semanticscholar   +1 more source

Synthetic Raphanobrassica Genome Reveals Functional and Evolutionary Insights Into Clubroot Resistance Genes on Chromosome R5

Plant Biotechnology Journal, EarlyView.
ABSTRACT Clubroot, a severe soil‐borne disease caused by Plasmodiophora brassicae, poses a severe threat to global production of Brassicaceae oilseed crops and vegetables. To date, there has been a serious lack of clubroot‐resistant germplasms in Brassica napus (AACC), necessitating the urgent development of novel disease‐resistant germplasm.
Xueqing Zhou, Meixiu Wu, Zhiquan Yang, Taihua Yang, Wenjing Li, Yingnan Liu, Yaru Shi, Aihua Wang, Peng Chen, Chao Liu, Qingyong Yang, Wenlin Yu, Chunyu Zhang   +12 more
wiley   +1 more source

Computational Design of Azole Derivatives as Multifunctional Agents for Alzheimer's Disease

Applied Organometallic Chemistry, Volume 40, Issue 5, May 2026.
A series of 19 azole derivatives were evaluated using bioinformatic tools and density functional theory in the context of multifunctional agents for Alzheimer's disease and were classified as potential antioxidant, distributor, and suppressor agents. ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, characterized by multifactorial ...
Nicolás Puentes‐Díaz, Yair Alvarez‐Ricardo, Diego Chaparro, Areli Flores‐Gaspar, John Hurtado, Jorge Alí‐Torres   +5 more
wiley   +1 more source

Recovery of platinum(IV) and palladium(II) from complex hydrochloric acid matrices by a thiodiglycolamide derivative [PDF]

, 2014
The solvent extraction performance of N,N’-dimethyl-N,N’-dicyclohexylthiodiglycolamide (DMDCHTDGA) towards Pt(IV) and Pd(II) in HCl solutions has recently been published.
Carvalho, G. I., Costa, Ana M. Rosa da, Costa, M. Clara, Nogueira, Carlos, Paiva, A. P.   +4 more
core  

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.

Journal of Medicinal Chemistry, 2018
A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme.
I. Buchler, D. Akuma, Vinh Au, G. Carr, Pablo de León, M. Depasquale, Glen E Ernst, Yifang Huang, M. Kimos, A. Kolobova, M. Poslusney, Huijun Wei, D. Swinnen, F. Montel, F. Moureau, Emilie Jigorel, Monika-Sarah E D Schulze, M. Wood, J. Barrow   +18 more
semanticscholar   +1 more source

Maintenance of Gut Microbial Balance via the Kynurenine Pathway Improves Larval Performance and Resistance to Bacillus thuringiensis in Spodoptera exigua

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
CRISPR/Cas9‐mediated deletion of kmo in Spodoptera exigua abolished 8‐HQA production, disrupted gut microbial homeostasis, and promoted Enterococcus dominance in gut and oral secretion. Mutants exhibited impaired growth, delayed development, and increased susceptibility to Bacillus thuringiensis, highlighting a conserved role of the kynurenine pathway ...
Daniel Pinos, Elena García‐Marín, Beatriz Ramírez‐Serrano, Luis Benavent‐Albarracín, Jordi Gamir, Cristina M. Crava   +5 more
wiley   +1 more source

Advances in LDHs for corrosion-resistant protection of Mg and Al alloys: A review

Journal of Magnesium and Alloys
Layered double hydroxides (LDHs) as coatings attract much attention in corrosion and protection of light metals due to their interesting properties such as in-situ synthesis, unique layer-stacking structure, tunable composition, and good biocompatibility
Lin Wang, Fen Zhang, Zuo-Jun Jiao, Lan-Yue Cui, Yuan-Ding Huang, Shuo-Qi Li, Cheng-Bao Liu, Rong-Chang Zeng   +7 more
doaj   +1 more source

Chelators in Iron and Copper Toxicity [PDF]

Purpose of Review Chelation therapy is used for diseases causing an imbalance of iron levels (for example haemochromatosis and thalassaemia) or copper levels (for example Menkes’ and Wilson’s diseases).
A Hartwig, A Kattamis, A Miyashiro, AC Dlouhy, AV Hoffbrand, B Gupta, BE Holbein, BE Kim, BM Olabinri, C Thephinlap, CG Roussaeux, CL Alden, CW Ritchie, DJ Kosman, DM Seely, DS Kalinowski, DW Cox, ED Rosenstein, G Lewis, GE Cartwright, GJ Brewer, HV Aposian, IS MacPherson, J Aaseth, J Aaseth, JH Menkes, JM Walshe, JM Walshe, K Aayush, K Brzóska, K Grasedyck, K Jomova, KA Winship, L Alan, L Lannfelt, M Nairz, MD Cappellini, MG Thompson, ML Schilsky, P Das, P Delangle, PJ Crouch, PJ Giardina, RL Anderson, RM Robins-Browne, RR Crichton, S Srichairatanakool, S Waldvogel-Abramowskia, SJS Flora, SK Das, SR Bareggi, T Umemura, TA Rouault, TD Rae, TP Kennedy, U Merle, V Laufberger, V Oliveri, Y Hiasa   +58 more
core   +1 more source

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

MedComm, Volume 7, Issue 4, April 2026.
Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng   +15 more
wiley   +1 more source

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease [PDF]

, 2016
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD.
Hagen Walle, Jan C. Koch, Katrin Eckermann, Lars Tatenhorst, Lars Tönges, Luis Fonseca-Ornelas, Markus Zweckstetter, Mathias Bähr, Paul Lingor, Stefan Becker, Tiago F. Outeiro, Tomás Lopes da Fonseca, Vivian Dambeck   +12 more
core   +3 more sources