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Physiologically Based Pharmacokinetic Modelling of Hydroxyurea in Patients with Sickle Cell Disease: A Special Focus on Lactating Women and Breastfed Infants to Inform Safe Dosing and Breastfeeding Strategies [PDF]

Pharmaceuticals
Background/Objectives: Hydroxyurea is currently the standard disease-modifying therapy for reducing sickle cell disease (SCD) complications; however, drug labels currently advise discontinuation of breastfeeding during hydroxyurea therapy due to limited ...
Khaled Abduljalil, Neel Deferm, Anna Murphy, Iain Gardner   +3 more
doaj   +2 more sources

Hydroxyurea utilization among individuals with sickle cell disease in Tennessee: a pooled analysis of claims data [PDF]

Frontiers in Pharmacology
ImportanceHydroxyurea reduces severe disease among individuals living with sickle cell disease (SCD). These individuals experience high acute care utilization, but the associations between patterns of hydroxyurea utilization and healthcare utilization ...
Ayesha Mukhopadhyay, Matthew P. Smeltzer, Judy Dudley, Sherif M. Badawy, Joacy G. Mathias, Allison P. Plaxco, Meredith A. Ray, Andrew D. Wiese, Walter I. Stevens, James G. Gurney, Chinonyelum Nwosu, Jerlym S. Porter, Lisa M. Klesges, Jane S. Hankins, William O. Cooper   +14 more
doaj   +2 more sources

Case Report: Late Hypersensitivity Reaction to Hydroxyurea in a Patient With Myeloproliferative Disorder [PDF]

Case Reports in Hematology
Hydroxyurea is a cornerstone therapy for myeloproliferative disorders such as early-stage myelofibrosis. However, rare hypersensitivity reactions can complicate its use and require careful management.
Navkirat Kahlon, Sujatha Baddam, Harinderjeet Kaur, Prabhat Singh, Zaheer Qureshi, Anusha Manje Gowda   +5 more
doaj   +2 more sources

Effect of treatment with hydroxyurea on calcium homeostasis in β-thalassemia-major patients

Al-Azhar Assiut Medical Journal, 2021
Background and aim Thalassemia is a chronic illness that has a range of serious clinical and psychological effects, it does not only affect the physical functioning of patients but also their emotional and social functioning and school functionings ...
Khaled H Hassan
doaj   +1 more source

A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia

Scientific Reports, 2022
Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven.
Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Ishari Silva, Nizri Hameed, Kumari Attanayaka, Rexan Rodrigo, Nirmani Wickramasinghe, Lakshman Perera, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda   +11 more
doaj   +1 more source

Barriers to hydroxyurea use from the perspectives of providers, individuals with sickle cell disease, and families: Report from a U.S. regional collaborative

Frontiers in Genetics, 2022
Sickle cell disease (SCD) is an inherited blood disorder that affects about 100,000 people in the U.S., primarily Blacks/African-Americans. A multitude of complications negatively impacts quality of life. Hydroxyurea has been FDA approved since 1998 as a
Marsha J. Treadwell, Marsha J. Treadwell, Lisa Du, Neha Bhasin, Neha Bhasin, Anne M. Marsh, Theodore Wun, M. A. Bender, Trisha E. Wong, Nicole Crook, Jong H. Chung, Shannon Norman, Nicolas Camilo, Judith Cavazos, Diane Nugent   +14 more
doaj   +1 more source

Spermatogenesis in Mice exposed to Hydroxyurea: Protecitve effect of ntural apple cider vinegar [PDF]

مجلة التربية والعلم, 2005
The effect of hydroxyurea at a close of 80mg/kg/day orally for (7) days on Spermatogenesis and the protective role of NACV (Natural apple cider vinegar) has been studied in mature male mice.
Aticka El-Nouri, Rafah Ayoub
doaj   +1 more source

Apparent Stability Constant of Zr(Ⅳ)-Hydroxyurea Complex With pH Potentiometric Titration

He huaxue yu fangshe huaxue, 2022
Hydroxyurea(HU) is a reducing and complexing agent that can be used in the PUREX process. Zr is an important fission product in the spent fuel and main element of concern in the nuclear fuel reprocessing.
YANG Ya-ya, YANG Shu-ming, LI Ming-ming, LIU Xiao-juan, NIE Jiang, LAN Tian, XIAO Song-tao, OUYANG Ying-gen   +7 more
doaj   +1 more source

Hydroxyurea pharmacokinetics and precision dosing in low-resource settings

Frontiers in Molecular Biosciences, 2023
Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia (SCA). Escalation to maximum tolerated dose (MTD) achieves superior benefits without additional toxicities, but requires dose adjustments with serial monitoring ...
Luke R. Smart, Luke R. Smart, Luke R. Smart, Mwesige Charles, Kathryn E. McElhinney, Min Dong, Min Dong, Alexandra Power-Hays, Alexandra Power-Hays, Alexandra Power-Hays, Thad Howard, Alexander A. Vinks, Alexander A. Vinks, Emmanuela E. Ambrose, Emmanuela E. Ambrose, Russell E. Ware, Russell E. Ware, Russell E. Ware   +17 more
doaj   +1 more source

Incorporation of thymidine into onion root meristematic cell nuclei in presence of hydroxyurea and its role in recovery of mitotic activity

Acta Societatis Botanicorum Poloniae, 2015
Hydroxyurea treatment of onion roots induced mitotic block which was released by transfer of bulbs to water, and also to some extent by addition of cold or 3H-thymidine to hydroxyurea solutions.
H. Habdas
doaj   +1 more source