Results 101 to 110 of about 61,606 (299)

The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress [PDF]

, 2011
A sessile lifestyle forces plants to respond promptly to factors that affect their genomic integrity. Therefore, plants have developed checkpoint mechanisms to arrest cell cycle progression upon the occurrence of DNA stress, allowing the DNA to be ...
Cools, Toon, Iantcheva, Anelia, Weimer, Annika K, Boens, Shannah, Takahashi, Naoki, Maes, Sara, Van Den Daele, Hilde, Van Isterdael, Gert, Schnittger, Arp, De Veylder, Lieven   +9 more
core   +2 more sources

Hydroxyurea Induced Tooth Discoloration

Turkish Journal of Hematology, 2019
WOS ...
Okuyucu, Muhammed, Atay, Memis Hilmi
openaire   +2 more sources

Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8‐Week Crossover Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the effects of premeal versus postmeal metformin administration on postmeal glycemic control in individuals with type 2 diabetes mellitus receiving metformin monotherapy. Methods All participants were randomly assigned to receive immediate‐release metformin either 30–60 min before or immediately after meal for 4 weeks, and ...
Issaree Rattarasarn, Chatvara Areevut, Khaimook Prachakeserane, La‐Or Chailurkit, Chutintorn Sriphrapradang, Chatchalit Rattarasarn   +5 more
wiley   +1 more source

Role of hydroxyurea therapy in the prevention of organ damage in sickle cell disease: a systematic review and meta-analysis

Systematic Reviews
Background Hydroxyurea is an affordable drug that reduces vaso-occlusive crises and transfusion requirements in sickle cell disease. However, its effectiveness in preventing chronic organ damage is still unclear.
Naveen Khargekar, Anindita Banerjee, Shreyasi Athalye, Namrata Mahajan, Neha Kargutkar, Prashant Tapase, Manisha Madkaikar   +6 more
doaj   +1 more source

Repair, abort, ignore? Strategies for dealing with UV damage [PDF]

, 2011
DNA repair is a prominent member of the nuclear transactions triad (replication, transcription, and repair). Sophisticated mechanisms govern the cellular process of decision-making (to repair or not to repair, to proceed with cell cycle or not and ...
Khalil, Hilal S., Tummala, Hemanth, Zhelev, Nikolai   +2 more
core   +3 more sources

Hydroxyurea-Induced Erythroid Differentiation

Experimental Biology and Medicine, 1975
Hydroxyurea, a cytotoxic agent which destroys cells in DNA synthesis, has been shown to evoke the differentiation of a small number of hemopoietic precursor cells in the erythroid series of erythropoietically suppressed hypertransfused mice. This effect does not appear to be mediated by erythropoietin (EP) since the simultaneous injection of anti-EP ...
N J, Rencricca, B S, Morse, F C, Monette, D, Howard, F, Stohlman   +4 more
openaire   +2 more sources

Drug Delivery Assessments of Hydroxyurea Anticancer by an Epoxy-Decorated Fullerene Cage

, 2022
Kun Harismah, Ali Hassan, Omar Hamid, Mohammed Saadoon, Hasan Zandi, N Jasem, M Al-Quzweny, A Alsammarraie, F Afzal, F Afzal, D Afzal, M Farahani, Z Hussain, M Cancan, F Afzal, M Cancan, S Ediz, D Afzal, F Chaudhry, M Farahani, B Farhadi, M Ebrahimi, A Morsali, A Shamsi, F Ahour, M Hassani, M Zeeb, A Monzavi, Z Khodadadi, M Kalaee, H Ahmed, N Abdulrahman, M Ali, M Islam, M Rafid, R Ahmed, M Jeetu, R Roy, U Chakma, A Kumer, H Darougari, M Rezaei-Sameti, S Hamidi Zare, M Ghorayshi Nejad, A Saberi, E Rostami, S Kreydie, B Al-Abdaly, Y Muhi-Alden, K Saleh, Y Elhenawy, Y Fouad, H Marouani, M Bassyouni, S Begum, H Ullah, I Ahmed, Y Zhan, A Kausar, M Aleem, S Ahmad, I Yasaroglu, O Aras, Y Kaya, M Mirzaei, O Gulseren, M Rafienia, A Zare, L Lavagna, R Nistic, S Musso, M Pavese, P Hanafizadeh, A Karimi, A Taklifi, A Hojati, A Dehno Khalaji, P Machek, M Jarosova, S Rostamzadeh Mansour, N Sohrabi-Gilani, P Nejati, A Pari, M Yousefi, S Samadi, M Allahgholi Ghasri, M Torbati, A Hatami, A Heydarinasab, A Akbarzadehkhiyavi, F Pajoum Shariati, S Hosseini, F Shojaie, D Afzali, P Makvandi, U Josic, M Delfi, J Makani Bassakouahou, C Kouala Landa, E Kimbally-Kaky   +99 more
openalex   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients.

Journal of Rawalpindi Medical College, 2019
Background: To compare hydroxyurea plus iron chelation therapy with iron chelation therapy alone in controlling iron overload in children with beta thalassaemia major.
Tatheer Zahra, Wajeeha Amber, Itrat Fatima   +2 more
doaj  

A Pharmacist-Managed Hydroxyurea Prescribing Protocol Improves Uptake and Optimization among Patients with Sickle Cell Disease

Advances in Hematology
Sickle cell disease (SCD) is a common genetic disorder with potentially serious sequelae that can be effectively treated with hydroxyurea. Despite its favorable benefit-risk profile, hydroxyurea uptake in patients with SCD is low.
Cameron Roessner, Trudy Sale, Kelsey Uminski, Dawn Goodyear, Natalia Rydz   +4 more
doaj   +1 more source