Results 121 to 130 of about 61,606 (299)

Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease

Hematology, Transfusion and Cell Therapy
To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease.
Clarisse Lobo, Aderson Araújo, Alexandre de Albuquerque Antunes, Ana Cristina Silva Pinto, Ariadne Carvalho Godinho, Cassia Silvestre Mariano Pires, Cinthia Cristina Matheus, Xerez de Albuquerque, Daniele Campos Fontes Neves, Fábio de Lima Moreno, Giorgio Baldanzi, Grazziella Curado Siufi, Heloisa Helena Pereira Miranda, Jane Hankins, Joice Aragão, Josefina Aparecida Pellegrini Braga, Juliana Touguinha Neves Martins, Luciana Campos Costa Machado de Souza, Maria Stella Figueiredo, Mirella Rodrigues Oliveira, Patricia Santos Resende Cardoso, Patricia Costa Alves Pinto, Patricia Gomes Moura, Rodolfo Delfini Cançado, Paulo Ivo Cortez de Araujo, Sara Olalla Saad, Sandra Regina Loggetto, Teresa Cristina Cardoso Fonseca   +27 more
doaj   +1 more source

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library [PDF]

, 2019
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents
Collins, Eva-Maria S., Hagstrom, D., Tanguay, R., Truong, L., Zhang, S.   +4 more
core   +1 more source

The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia‐Associated Kidney Function

American Journal of Hematology, Volume 101, Issue 6, Page 1341-1350, June 2026.
ABSTRACT Progressive kidney injury is a major cause of morbidity and mortality in sickle cell anemia (SCA). The high risk APOL1 G1/G2 variants contribute to the development of kidney disease in individuals of African ancestry, including those with SCA.
Sara R. Rashkin, Guolian Kang, Clifford M. Takemoto, Mitchell J. Weiss, Kenneth I. Ataga, Santosh L. Saraf, Jeffrey Lebensburger, Rima S. Zahr   +7 more
wiley   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela, Raffael Silva Santos Almeida, Ivana Ferreira Simões, Aline Gonçalves Miranda, Magno Oliveira Ramos, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa, Aníbal de Freitas Santos Júnior   +7 more
wiley   +1 more source

Effect of Hydroxyurea Therapy on Growth Parameters in Older Children (6-15 Year-Old) with Sickle Cell Disease: Low Dose Versus High Dose

, 2023
Doaa Khater, Sharef Al‐Mulaabed, Anwar Alomairi, Mohamed Elshinawy, Ashraf Soliman, Noor Elshinawy, Yasser Wali, Saif Al-Yaarubi   +7 more
openalex   +2 more sources

Risk of Transformation to Acute Myeloid Leukaemia and Myelodysplastic Syndromes in Patients With Myeloproliferative Neoplasms Over Attained Age and Time Since Diagnosis: A Nationwide Cohort Study

European Journal of Haematology, Volume 116, Issue 6, Page 850-862, June 2026.
ABSTRACT Background Individuals with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) face transformation risks to acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). While older age is linked to increased risk, it remains unclear whether risk increases with age or with disease duration.
Nurgul Batyrbekova, Anna Ravn Landtblom, Malin Hultcrantz, Robert Szulkin, Paul W. Dickman, Therese M.‐L. Andersson   +5 more
wiley   +1 more source

P05.45 Hydroxyurea (HU) or VAC (vincristine, adriamycin and cyclophosphamide) in a group of recurrent meningioma patients [PDF]

, 2018
Antonio Silvani, G. Simonetti, L Elena Antonia, Bianca Pollo, Laura Fariselli, Paola Gaviani   +5 more
openalex   +1 more source

Giant cellulitis‐like Sweet's syndrome induced by gilteritinib

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Juan de Luque‐Fernández, Irene Rivera‐Ruiz, Irene Suárez‐Vergne, Inmaculada Sánchez‐Ramírez, Manuel Galán‐Gutiérrez, Antonio José Vélez García‐Nieto   +5 more
wiley   +1 more source

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Structural and Mechanistic Studies of γ-Fe2O3 Nanoparticle as Hydroxyurea Drug Nanocarrier

Orbital: The Electronic Journal of Chemistry, 2019
In this study, the noncovalent interactions and four mechanisms of covalent functionalization of hydroxyurea have been examined using the density functional theory. Quantum molecular descriptors were also studied in noncovalent interactions.
Sadaf Avarand, Ali Morsali, Mohammad Moemen Heravi, Safar Ali Beyramabadi   +3 more
doaj