Results 251 to 260 of about 61,606 (299)

Hydroxyurea-induced leg ulcers

Hospital Medicine, 2000
Hydroxyurea is an analogue of urea that inhibits DNA synthesis. It inhibits ribonucleotide reductase, the enzyme which converts ribonucleotide diphosphates to their deoxyribonucleotide forms. This causes selective killing of cells in the S phase of the cell cycle.
J, Murphy, S M, Morley
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Hydroxyurea: Mechanism of Action

Science, 1963
Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.
W N, FISHBEIN, P P, CARBONE
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Hydroxyurea Therapy

Archives of Dermatology, 1973
L D, Roe, J W, Wilson
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Hydroxyurea and Bronchogenic Carcinoma

Australasian Radiology, 1974
SUMMARYThe disappointing outlook in the treatment and prognosis of lung cancer still continues and is an enigma which baffles clinicians in the management of this disease.A selected clinical trial was carried out in the Royal Adelaide Hospital using hydroxyurea and irradiation in one group of patients versus a placebo group who received irradiation ...
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Hydroxyurea enhances sickle survival

Blood, 2010
In this issue of Blood, Voskaridou et al provide more compelling evidence that hydroxyurea improves survival in adults with severe sickle cell disease.1 This comes at the centennial of the recognition of sickle cell disease in Western medicine. Considerable progress has been made in understanding the pathophysiology of this complex disease caused by a ...
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Hydroxyurea and infected stones

Urology, 1978
The formation of struvite stones is closely linked to the enzyme urease produced by certain bacteria found in urine. It has been shown that hydroxamic acids will block the activity of this enzyme. One of these, hydroxyurea, in a morning dose of 500 mg. was used in 21 patients for three months or longer.
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Hydroxyurea

2022
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Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa

New England Journal of Medicine, 2020
Chandy C John, Robert O Opoka, Phillip Kasirye   +2 more
exaly  

Hydroxyurea*

Reactions, 1980
openaire   +1 more source

Psoriasis and Hydroxyurea

British Journal of Dermatology, 1972
R, Touraine, J, Revuz, M, Tulliez
openaire   +2 more sources