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Treating sickle cell anemia [PDF]

Science, 2020
New drugs, stem cell transplants, and gene therapy show promise in treating sickle cell ...
John F, Tisdale, Swee Lay, Thein, William A, Eaton   +2 more
openaire   +3 more sources

Sickle cell anemia [PDF]

Nursing Made Incredibly Easy!, 2020
Genes are translated into proteins; mutations often (but not always) result in changes in the sequence of amino acids in those proteins. Changes in the amino acid sequence can modify (in various ways) or even completely destroy protein function. Proteins
Hyun Sue Kim, L. Yospur, Y. Niihara
semanticscholar   +4 more sources

Self-resolution of spontaneous epidural hematoma in sickle cell anemia: A case report [PDF]

Radiology Case Reports
Spontaneous epidural hematoma is a rare and dangerous complication of sickle cell anemia which typically requires surgical management. We present a rare case of a patient with sickle cell anemia and intracranial spontaneous epidural hematoma which ...
Shruti Kumari, MD, Grayson H. Hooper, DO, Ameya Nayate, MD   +2 more
doaj   +2 more sources

Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2018
OBJECTIVE: To determine the mortality rate of children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. METHODS: The number of deaths, the mortality rate and the causes of deaths in patients with sickle cell anemia who were ...
Ballas, Samir K., Freitas, Thiago Gotelip de, Jesus, Leonardo José Carvalho de, Lobo, Clarisse Lopes de Castro, Lugon, Jocemir Ronaldo, Nascimento, Emilia Matos do   +5 more
core   +4 more sources

Radiologic Evaluation of Paranasal Sinuses in Sickle Cell Anemia and Thalassemia: Case–Control Study [PDF]

Laryngoscope Investigative Otolaryngology
Background Sickle cell disease and thalassemia are inherited hematological disorders that are common worldwide. These patients suffer from chronic hemolytic anemia, which can result in bone marrow dysfunction and, in rare cases, extramedullary ...
Maha A. Alharbi, Ayat AlDarwish, Reem M. Alamier, Nawal E. Omer, Mahmoud A. Alabbad, Abdulmohsin M. Aljassem, Qasem M. ALalwan, Danah H. Althomaly, Hussain Abdullali Albaharna   +8 more
doaj   +2 more sources

A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2016
Background: Treatment of sickle cell anemia is a challenging task and despite the well understood genetic and biochemical pathway of sickle hemoglobin, current therapy continues to be limited to the symptomatic treatment of pain, supplemental oxygen ...
Hemant Misra, James Bainbridge, John Berryman, Abraham Abuchowski, Kenneth Mauricio Galvez, Luis Fernando Uribe, Angel Luis Hernandez, Nestor Rodolfo Sosa   +7 more
doaj   +2 more sources

Sickle Cell Anemia [PDF]

RadioGraphics, 2001
Sickle cell anemia (SCA) is a disease caused by production of abnormal hemoglobin, which binds with other abnormal hemoglobin molecules within the red blood cell to cause rigid deformation of the cell. This deformation impairs the ability of the cell to pass through small vascular channels; sludging and congestion of vascular beds may result, followed ...
G J, Lonergan, D B, Cline, S L, Abbondanzo   +2 more
  +5 more sources

Role of sickling crisis with serum zinc in children with sickle cell anemia

Advanced Medical Journal, 2022
Background and objectives: Sickle cell anemia causes painful crises by the occlusion of small blood vessels by spontaneous intravascular sickling. The aim of this study is to determine the possible association of Zinc deficiency with painful crises ...
Bahzad Khalid Sharaf, Akrem Mohammad Atrushi   +1 more
doaj   +1 more source

Knowledge and DdeI Based Confirmation of Sickle Cell Anemia Among the Tharu Community

Journal of Nepal Health Research Council, 2022
Background: Sickle cell anemia is an inherited blood disorder caused due to a point mutation at the sixth codon of the ?-globin gene of both alleles. Sickle cell traits occur when the mutation is in one of the two alleles of the ?-globin genes.
Sajani Ghaju, Karan Khadayat, Raju Shrestha, Salan Ghaju, Trishna Manandhar, Bishnu P. Marasini   +5 more
doaj   +1 more source

Identification of Sickle Cell Anemia Using Deep Neural Networks

, 2021
A molecule called hemoglobin is found in red blood cells that holds oxygen all over the body. Hemoglobin is elastic, round, and stable in a healthy human. This makes it possible to float across red blood cells.
Sagar Yeruva, M. Varalakshmi, B. Gowtham, Y. Chandana, P. K. Prasad   +4 more
semanticscholar   +1 more source