Results 21 to 30 of about 5,070,713 (217)

Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study. [PDF]

, 2009
BACKGROUND: In sub-Saharan Africa, more than 90% of children with sickle-cell anaemia die before the diagnosis can be made. The causes of death are poorly documented, but bacterial sepsis is probably important.
Uyoga, Sophie, Berkley, James, Macharia, Alex, McAuley, Charlotte F, Opi, DH, Kevin Marsh, J Anthony G Scott, Mwarumba, Salim, Berkley, James A, Ndila, C, Scott, John, Carolyne Ndila, Berkley, JA, Thomas N Williams, Sophie Uyoga, Williams, TN, Makani, J, James A Berkley, Sharif, SK, McAuley, CF, Daniel H Opi, Mwarumba, S, Uyoga, S, Macharia, A, Albert Komba, Marsh, K, Scott, JA, Charlotte F McAuley, Sharif, Shahnaaz K, Scott, J Anthony G, Williams, Thomas N, Julie Makani, Ndiritu, Moses N, Salim Mwarumba, Moses N Ndiritu, Komba, Albert, Williams, Thomas, Komba, A, Opi, Daniel H, Makani, Julie, Marsh, Kevin, Ndiritu, MN, Alex Macharia, Shahnaaz K Sharif, Ndila, Carolyne   +44 more
core   +1 more source

Murine models of sickle cell disease and beta‐thalassemia demonstrate pulmonary hypertension with distinctive features

Pulmonary Circulation, 2021
Sickle cell anemia and β‐thalassemia intermedia are very different genetically determined hemoglobinopathies predisposing to pulmonary hypertension. The etiologies responsible for the associated development of pulmonary hypertension in both diseases are ...
Paul W. Buehler, Delaney Swindle, David I. Pak, Mehdi A. Fini, Kathryn Hassell, Rachelle Nuss, Rebecca B. Wilkerson, Angelo D’Alessandro, David C. Irwin   +8 more
doaj   +1 more source

Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia. [PDF]

, 2013
Low hemoglobin oxygen saturation (SpO2) is common in Sickle Cell Anemia (SCA) and associated with complications including stroke, although determinants remain unknown.
Cox, Sharon E, Newton, Charles R, Makani, Julie, Prentice, Andrew M, Kirkham, Fenella J   +4 more
core   +1 more source

The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment

Trends in Peptide and Protein Sciences, 2021
Sickle cell diseases are the most prevalent monogenic blood diseases with complications such as severe end-organ harm, pain, and reduced life expectancy. Dealing options for sickle cell diseases are inadequate, as there are just two FDA-approved drugs to
Vida Ebrahimi, Atieh Hashemi
doaj   +1 more source

A Health Educational Program for Mothers with Children Suffering from Sickle Cell Anemia [PDF]

Helwan International Journal for Nursing Research and Practice
Background: Sickle cell anemia is a hereditary blood disorder characterized by the production of abnormal hemoglobin. Children with sickle cell anemia suffer from chronic pain, frequent infections, and fatigue due to the blockage of blood flow and the ...
Marwa Younes
doaj   +1 more source

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease

Haematologica, 2013
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz, Marc Romana, Marie-Laure Lalanne-Mistrih, Roberto F. Machado, Yann Lamarre, Vanessa Tarer, Marie-Dominique Hardy-Dessources, Benoît Tressières, Lydia Divialle-Doumdo, Marie Petras, Frederic Maillard, Maryse Etienne-Julan, Philippe Connes   +12 more
doaj   +1 more source

Association between sickle cell and β-thalassemia genes and hemoglobin concentration and anemia in children and non-pregnant women in Sierra Leone: ancillary analysis of data from Sierra Leone’s 2013 National Micronutrient Survey

BMC Research Notes, 2018
Objective By measuring the associations between the presence of sickle cell and β-thalassemia genes, we assessed the extent to which these hemoglobinopathies contribute to the high prevalence of anemia observed in preschool-aged children and women of ...
James P. Wirth, Rashid Ansumana, Bradley A. Woodruff, Aminata S. Koroma, Mary H. Hodges   +4 more
doaj   +1 more source

Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies

Revista Brasileira de Hematologia e Hemoterapia, 2011
Sickle cell anemia is the best known hereditary blood disorder; there are serious complications associated with the condition. Diagnosis and early intervention reduce morbidity and mortality.
Luciana Garcia Lervolino, Paulo Eduardo Almeida Baldin, Silvia Miguéis Picado, Karina Barreto Calil, Ana Amélia Viel, Luiz Alexandre Freixo Campos   +5 more
doaj   +1 more source

Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate

Case Reports in Infectious Diseases, 2019
Treatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution.
Abdulrahman Hummadi, Sultan Mubarki, Ayel yahay, Awad Mohammed Al-Qahtani   +3 more
doaj   +1 more source

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Haematologica, 2009
Background Recent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation.
Julien Tripette, Tamas Alexy, Marie-Dominique Hardy-Dessources, Daniele Mougenel, Eric Beltan, Tawfik Chalabi, Roger Chout, Maryse Etienne-Julan, Olivier Hue, Herbert J. Meiselman, Philippe Connes   +10 more
doaj   +1 more source