Results 1 to 10 of about 7,022 (111)
Nature Reviews Disease Primers, 2018 Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Haemoglobin molecules that include mutant sickle β-globin subunits can polymerize; erythrocytes that ...
Frédéric B. Piel +2 more
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Anemia, 2023 Introduction. Chronic hemolysis predisposes sickle cell patients to the development of gallstones. Their frequency increases with age, but they may appear early in young children.
Firmine Olivia Galiba Atipo Tsiba +6 more
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BMC Public Health, 2023 Background Globally, Sickle cell disease (SCD) is one of the most common genetic disease with high childhood mortality. Early identification of babies with SCD through newborn screening (NBS) and linking them to care are among the recommended ...
Hilda J. Tutuba +9 more
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Thalassemia Reports, 2022 During a pandemic, people are fearful of becoming infected with the virus, which causes anxiety, loss of purpose, and depression. This study aimed to evaluate the social and psychological impact, as well as the impact on homecare, of patients with ...
Sophia Delicou +10 more
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Sickle cell disease patients with COVID‐19 in Guadeloupe: Surprisingly favorable outcomes
eJHaem, 2022 We investigate risk factors for hospitalization and difference between sickle cell syndromes in a cohort of COVID‐19 sickle cell disease (SCD) adult patients managed in the Reference Center of Guadeloupe.
Emmanuelle Bernit +10 more
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BMC Health Services Research, 2020 Background Monitoring patient’s clinical attendance is a crucial means of improving retention in care and treatment programmes. Sickle cell patients’ outcomes are improved by participation in comprehensive care programmes, but these benefits cannot be ...
Upendo Masamu +8 more
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HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription
Retrovirology, 2018 Background HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. Results Mass spectrometry
Andrey Ivanov +9 more
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Sickle cells and sickle trait in thrombosis [PDF]
Blood, 2019 The blood cells form a beautiful and elegant system. For a century, hematologists have comfortably understood that each type of blood cell has its own independent function in immunity, hemostasis, or oxygen transport, but in this issue of Blood, Faes and colleagues show that nature is far more efficient than that.
openaire +2 more sources
New England Journal of Medicine, 2017 Sickle cell disease is an increasing global health problem. Estimates suggest that every year approximately 300,000 infants are born with sickle cell anemia, which is defined as homozygosity for the sickle hemoglobin (HbS) gene (i.e., for a missense mutation [Glu6Val, rs334] in the β-globin gene [HBB]) and that this number could rise to 400,000 by 2050.
Piel, FB, Steinberg, MH, Rees, DC
openaire +12 more sources
Identification of the Rare, Four Repeat Allele of IL-4 Intron-3 VNTR Polymorphism in Indian Populations [PDF]
Iranian Journal of Immunology, 2016 Background: Cytokines are cell signaling molecules which upon release by cells facilitate the recruitment of immune-modulatory cells towards the sites of inflammation. Genetic variations in cytokine genes are shown to regulate their production and affect
Henu Kumar Verma +4 more
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