Results 21 to 30 of about 4,991,463 (296)

HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

Mediterranean Journal of Hematology and Infectious Diseases, 2009
Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli   +3 more
doaj   +1 more source

Healthcare Workers’ Knowledge and Resource Availability for Care of Sickle Cell Disease in Dar es Salaam, Tanzania

Frontiers in Genetics, 2022
Background: Sickle cell disease (SCD) is a global public health priority due to its high morbidity and mortality. In Tanzania, SCD accounts for 7% of under-five mortality. Cost-effective interventions such as early diagnosis and linkage to care have been
Agnes Jonathan, Agnes Jonathan, Hilda Tutuba, Hilda Tutuba, William Lloyd, Joyce Ndunguru, Joyce Ndunguru, Julie Makani, Julie Makani, Paschal Ruggajo, Paschal Ruggajo, Irene K. Minja, Irene K. Minja, Emmanuel Balandya, Emmanuel Balandya   +14 more
doaj   +1 more source

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Blood Advances, 2016
: The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We
Namita Kumari, Tatiana Ammosova, Sharmin Diaz, Xionghao Lin, Xiaomei Niu, Andrey Ivanov, Marina Jerebtsova, Subhash Dhawan, Patricia Oneal, Sergei Nekhai   +9 more
doaj   +1 more source

Using DNA testing for the precise, definite, and low-cost diagnosis of sickle cell disease and other Haemoglobinopathies: findings from Tanzania

BMC Genomics, 2021
Background Sickle cell disease (SCD) is an important cause of under-five mortality. Tanzania is the 5th country in the world with the highest births prevalence of SCD individuals. Significant advances in the neonatal diagnosis of SCD using rapid point-of-
Heavenlight Christopher, Adam Burns, Emmanuel Josephat, Julie Makani, Anna Schuh, Siana Nkya   +5 more
doaj   +1 more source

Odisha Revisited: A Personal Account

Frontiers in Medicine, 2021
In 1986, a paper in the Lancet was the first to collate hematology, molecular findings, and clinical features of homozygous sickle cell (SS) disease in India.
Graham R. Serjeant, Andreas E. Kulozik, Beryl E. Serjeant   +2 more
doaj   +1 more source

The additional genetic diagnosis of homozygous sickle cell disease in a patient with Waardenburg-Shah syndrome: a case report

Journal of Medical Case Reports, 2019
Background It is important that multiple genetic diagnoses are not missed. This case report describes the clinical features and management of a patient with co-inheritance of Waardenburg syndrome type 4 or Waardenburg-Shah syndrome, an extremely rare ...
Angela E. Rankine-Mullings, Graham Serjeant, Zachary Ramsay, Neil A. Hanchard, Monika Asnani   +4 more
doaj   +1 more source

Sickle-cell disease

The Lancet, 2010
Sickle-cell disease is one of the most common severe monogenic disorders in the world. Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anaemia, haemolysis, and vasculopathy has been established.
Rees, David C., Williams, Thomas N., Gladwin, Mark T.   +2 more
openaire   +4 more sources

Sickle Cell Hepatopathy [PDF]

Hepatology, 2001
Sickle cell hepatopathy encompasses a range of hepatic pathology arising from a wide variety of insults to the liver in patients with sickle cell disease. It occurs predominantly in patients with homozygous sickle cell anemia, and to a lesser extent in patients with sickle cell trait, Hb SC disease and Hb S b thalassemia.
S, Banerjee, C, Owen, S, Chopra
openaire   +2 more sources

An Imaging Flow Cytometry Method to Measure Citrullination of H4 Histone as a Read-out for Neutrophil Extracellular Traps Formation

Bio-Protocol, 2021
The formation of neutrophil extracellular traps (NETs) is thought to play a critical role in infections and propagating sterile inflammation. Histone citrullination is an essential and early step in NETs formation, detectable prior to the formation of ...
Emilia Barbu, Venina Dominical, Laurel Mendelsohn, Swee Lay Thein   +3 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source