Results 21 to 30 of about 105,245 (307)

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Blood Advances, 2016
: The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We
Namita Kumari, Tatiana Ammosova, Sharmin Diaz, Xionghao Lin, Xiaomei Niu, Andrey Ivanov, Marina Jerebtsova, Subhash Dhawan, Patricia Oneal, Sergei Nekhai   +9 more
doaj   +1 more source

Odisha Revisited: A Personal Account

Frontiers in Medicine, 2021
In 1986, a paper in the Lancet was the first to collate hematology, molecular findings, and clinical features of homozygous sickle cell (SS) disease in India.
Graham R. Serjeant, Andreas E. Kulozik, Beryl E. Serjeant   +2 more
doaj   +1 more source

Using DNA testing for the precise, definite, and low-cost diagnosis of sickle cell disease and other Haemoglobinopathies: findings from Tanzania

BMC Genomics, 2021
Background Sickle cell disease (SCD) is an important cause of under-five mortality. Tanzania is the 5th country in the world with the highest births prevalence of SCD individuals. Significant advances in the neonatal diagnosis of SCD using rapid point-of-
Heavenlight Christopher, Adam Burns, Emmanuel Josephat, Julie Makani, Anna Schuh, Siana Nkya   +5 more
doaj   +1 more source

The additional genetic diagnosis of homozygous sickle cell disease in a patient with Waardenburg-Shah syndrome: a case report

Journal of Medical Case Reports, 2019
Background It is important that multiple genetic diagnoses are not missed. This case report describes the clinical features and management of a patient with co-inheritance of Waardenburg syndrome type 4 or Waardenburg-Shah syndrome, an extremely rare ...
Angela E. Rankine-Mullings, Graham Serjeant, Zachary Ramsay, Neil A. Hanchard, Monika Asnani   +4 more
doaj   +1 more source

An Imaging Flow Cytometry Method to Measure Citrullination of H4 Histone as a Read-out for Neutrophil Extracellular Traps Formation

Bio-Protocol, 2021
The formation of neutrophil extracellular traps (NETs) is thought to play a critical role in infections and propagating sterile inflammation. Histone citrullination is an essential and early step in NETs formation, detectable prior to the formation of ...
Emilia Barbu, Venina Dominical, Laurel Mendelsohn, Swee Lay Thein   +3 more
doaj   +1 more source

Sickle Cell Disease

Transfusion Medicine and Hemotherapy
Background: Sickle cell disease (SCD) is among the most frequent hereditary disorders globally and its prevalence in Europe is increasing due to migration movements. Summary: The basic pathophysiological event of SCD is polymerization of deoxygenated sickle hemoglobin, resulting in hemolysis, vasoocclusion, and multiorgan damage.
Kunz, Joachim B., Tagliaferri, Laura
openaire   +4 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Transition Readiness of Pediatric Sickle Cell Patients to Adult Clinic in a Teaching Hospital, Ghana

Advances in Hematology
Conclusion: The study revealed a high transition readiness among pediatric patients. In general, the patients had high confidence transitioning to an adult clinic and the ability to manage their own healthcare.
Aaron Kwasi Nartey, Vivian Paintsil, Isaac Nyanor, Yaa Gyamfua Oppong-Mensah, Evans Xorse Amuzu, Eunice Agyeman Ahmed, Suraj Yawnumah Abubakar, Alex Osei-Akoto   +7 more
doaj   +1 more source

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin

Haematologica, 2013
Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai, Min Xu, Altreisha Foster, Ishmael Kasvosve, Sharmin Diaz, Roberto F. Machado, Oswaldo L. Castro, Gregory J. Kato, James G. Taylor, Victor R. Gordeuk   +9 more
doaj   +1 more source

Increased Prevalence of Alloimmunization in Sickle Cell Disease? Should We Restore Blood Donation in French Guiana?

Frontiers in Medicine, 2021
Patients with sickle cell disease often undergo frequent blood transfusions. This increases their exposure to red blood cell alloantigens of donor units, thus making it more likely that they produce alloantibodies.
Salomé Conrath, Vincent Vantilcke, Mickael Parisot, Françoise Maire, Pierre Selles, Narcisse Elenga, Narcisse Elenga   +6 more
doaj   +1 more source