Results 11 to 20 of about 216,468 (292)

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa.

New England Journal of Medicine, 2020
BACKGROUND Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso-occlusive events and reduced mortality.
C. John, R. Opoka, Teresa S. Latham, H. Hume, Catherine Nabaggala, Phillip Kasirye, C. Ndugwa, A. Lane, R. Ware   +8 more
semanticscholar   +3 more sources

Hydroxyurea for Children with Sickle Cell Anemia in Sub‐Saharan Africa

New England Journal of Medicine, 2019
BACKGROUND Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub‐Saharan Africa, where the burden is greatest.
L. Tshilolo, G. Tomlinson, T. Williams, Brígida Santos, P. Olupot‐Olupot, A. Lane, B. Aygun, Susan E Stuber, Teresa S. Latham, Patrick T. McGann, R. Ware   +10 more
semanticscholar   +3 more sources

Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.

New England Journal of Medicine, 2014
BACKGROUND Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent cerebral infarct).
M. DeBaun, M. Gordon, R. C. McKinstry, M. Noetzel, D. A. White, S. Sarnaik, R. E., Meier, T. Howard, S. Majumdar, B. Inusa, P. Telfer, M. Kirby-Allen, T. McCavit, A., Kamdem, G. Airewele, G. Woods, B. Berman, J. Panepinto, B. R. Fuh, J. L. Kwiatkowski, A. King, J. Fixler, M. Rhodes, A. Thompson, M. Heiny, R. C. Redding-Lallinger, F. Kirkham, N. Dixon, C. E. Gonzalez, K. Kalinyak, C. T. Quinn, J. Strouse, J. Miller, H. Lehmann, M. A. Kraut, W. Ball, D. Hirtz, J. F. Casella   +39 more
semanticscholar   +3 more sources

Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.

New England Journal of Medicine, 1998
R. Adams, V. Mckie, L. Hsu, B. Files, E. Vichinsky, C. Pegelow, M. Abboud, D. Gallagher, A. Kutlar, F. Nichols, D. Bonds, D. Brambilla, G. Woods, N. Olivieri, C. Driscoll, Scott T. Miller, Winfred C. Wang, Anne Hurlett, C. Scher, B. Berman, Elizabeth Carl, Anne M. Jones, E. Roach, Elizabeth C. Wright, R. Zimmerman, M. Waclawiw   +25 more
semanticscholar   +3 more sources

Deep Learning Models for Classification of Red Blood Cells in Microscopy Images to Aid in Sickle Cell Anemia Diagnosis

Electronics, 2020
Sickle cell anemia, which is also called sickle cell disease (SCD), is a hematological disorder that causes occlusion in blood vessels, leading to hurtful episodes and even death.
Laith Alzubaidi, M. Fadhel, O. Al-Shamma, Jinglan Zhang, Y. Duan   +4 more
semanticscholar   +1 more source

The multifaceted role of ischemia/reperfusion in sickle cell anemia.

Journal of Clinical Investigation, 2020
Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular in its origin, cyclicity, complexity, instability, perpetuity, and ...
R. Hebbel, J. Belcher, G. Vercellotti
semanticscholar   +1 more source

Splenic sequestration and infarction upon exposure to high altitude in adult patients with sickle cell anemia

Journal of Applied Hematology, 2023
Adult patients with sickle cell disease usually have atrophied spleens due to autosplenectomy, and only rarely have complications related to the spleen, such as splenic sequestration and infarctions.
Husain Alkhaldy, Mortadah Alsalman, Mariyyah Almuhaini, Renad Alshehri, Samar Almusaad, Wejdan Al-Qahtani, Tamer A Samih, Mohammed Makkawi   +7 more
doaj   +1 more source

Fetal Hemoglobin in Sickle Cell Anemia.

Blood, 2020
Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course and offer prospects for curative therapy of sickle cell disease. This review focuses on: 1.
M. Steinberg
semanticscholar   +1 more source

HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

Mediterranean Journal of Hematology and Infectious Diseases, 2009
Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli   +3 more
doaj   +1 more source

Peripheral Red Blood Cell Split Chimerism as a Consequence of Intramedullary Selective Apoptosis of Recipient Red Blood Cells in a Case of Sickle Cell Disease

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Allogeneic cellular gene therapy through hematopoietic stem cell transplantation is the only radical cure for congenital hemoglobinopathies like thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Pietro Sodani, Javid Gaziev, Daniela Fraboni, Katia Paciaroni, Cristiano Gallucci, Cecilia Alfieri, Andrea Roveda, Gioia De Angelis, Luisa Cardarelli, Michela Ribersani, Marco Andreani, Guido Lucarelli   +13 more
doaj   +1 more source