Results 81 to 90 of about 4,710,511 (291)

Accelerated construction of projection-based reduced-order models via incremental approaches

Advanced Modeling and Simulation in Engineering Sciences
We present an accelerated greedy strategy for training of projection-based reduced-order models for parametric steady and unsteady partial differential equations.
Eki Agouzal, Tommaso Taddei
doaj   +1 more source

Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H2O2 biosensor HyPer

Redox Biology, 2019
In this study, we propose a method for quantification of average hydrogen peroxide concentration within a living cell that is based on the use of genetically encoded H2O2 biosensor HyPer.
Olga Lyublinskaya, Fernando Antunes
doaj   +1 more source

On the Hyper-Reduction of variational inequalities. Application to contact mechanics problems.

, 2023
This work deals with efficient reduced order modeling for variational inequalities treated by a mixedformulation. The problem arising for the High Fidelity (HF) formulation is then a saddle-point problemimplying positive Lagrange multipliers. To overcome the issue of finding an accurate positive reducedbasis for the Lagrange multipliers, the Hybrid ...
Ramiere, Isabelle, LE BERRE, Simon, Ryckelynck, David   +2 more
openaire   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Psychosocial and Pedagogical Means of Reduction of Hyper Dynamic Manifestations Syndrome Within the Affective Personality Disorder

Journal of Vasyl Stefanyk Precarpathian National University, 2017
The problem of correction of affective personality disorders (for example, reducing the manifestations of hyper dynamic syndrome), analyzes the main approaches to its solution.
Liana Novitska
doaj   +1 more source

Hyper-parameters for online optimization of the proposed network.

, 2022
Hyper-parameters for online optimization of the proposed network.
Hui Xiao (185054), Gao Gong (12870371), Shi Cao (5905274), Weiyang Fang (14265757), Chaomin Chen (14265760)   +4 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Dimensionality reduction of the attributes using fuzzy optimized independent component analysis for a Big Data Intrusion Detection System

Научно-технический вестник информационных технологий, механики и оптики
Big data cybersecurity has garnered more attraction in recent years with the development of advanced machine learning and deep learning classifiers. These new classifier algorithms have significantly improved Intrusion Detection Systems (IDS).
R. Aswanandini, Ch. Deepa
doaj   +1 more source

Hyper-parameters for SuperVec, Seq2Vec and SuperVecX.

, 2020
Hyper-parameters for SuperVec, Seq2Vec and SuperVecX.
Dhananjay Kimothi (8575089), James M. Hogan (8575095), Wayne Kelly (8575101), Pravesh Biyani (8575092), Akshay Soni (8575098)   +4 more
core   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source