Results 181 to 190 of about 2,853 (274)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

When Universities Turn Carceral: Between Academic Freedom and Elimination

The British Journal of Sociology, EarlyView.
Gil Rothschild Elyassi
wiley   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Hierarchical Differentiable Fluid Simulation

Computer Graphics Forum, EarlyView.
We introduce a two‐step algorithm that significantly reduces memory usage for solving control problems using differentiable fluid simulation techniques: our method first optimizes for bulk forces at reduced resolution, then refines local details over sub‐domains while maintaining differentiability. In trading runtime for memory, it enables optimization
Xiangyu Kong, Arnaud Schoentgen, Damien Rioux‐Lavoie, Paul G. Kry, Derek Nowrouzezahrai   +4 more
wiley   +1 more source

Multi‐Spectral Gaussian Splatting with Neural Color Representation

Computer Graphics Forum, EarlyView.
Abstract 3D Gaussian Splatting (3DGS) [KKLD23] has transformed novel‐view synthesis from RGB images, yet remains restricted to the visible spectrum. Many applications, including agricultural monitoring, rely on multi‐spectral imaging, where spectral camera alignment and scalability pose major challenges.
Lukas Meyer, Josef Grün, Maximilian Weiherer, Bernhard Egger, Marc Stamminger, Linus Franke   +5 more
wiley   +1 more source

LRRT*: A robotic arm path planning algorithm based on an improved Levy flight strategy with effective region sampling RRT. [PDF]

PLoS One
Gu Y, Luo H, Gong W, Jiang Y, Yuan T, Cao L, Li H, Zhang W.   +7 more
europepmc   +1 more source

Self‐supervised Learning of Fine‐to‐Coarse Cuboid Shape Abstraction

Computer Graphics Forum, EarlyView.
Abstract The abstraction of 3D objects with simple geometric primitives like cuboids allows us to infer structural information from complex geometry. It is important for 3D shape understanding, structural analysis and geometric modeling. We introduce a novel fine‐to‐coarse self‐supervised learning approach to abstract collections of 3D shapes.
Gregor Kobsik, Morten Henkel, Yanjiang He, Victor Czech, Tim Elsner, Isaak Lim, Leif Kobbelt   +6 more
wiley   +1 more source

Underwater Robots and Key Technologies for Operation Control. [PDF]

Cyborg Bionic Syst
Sun L, Wang Y, Hui X, Ma X, Bai X, Tan M.   +5 more
europepmc   +1 more source

Skeletal‐Driven Animation of Anatomical Humans via Neural Deformation Gradients

Computer Graphics Forum, EarlyView.
Abstract Most real‐time animation techniques for digital humans are limited to deforming the outer skin surface. Geometric skinning methods are highly efficient but struggle with artifacts such as collapsing joints or self‐intersections when animating inner anatomy along with the outer skin.
G. Nolte, F. Kemper, U. Schwanecke, M. Botsch   +3 more
wiley   +1 more source